DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dyrk1a and Hipk

DIOPT Version :9

Sequence 1:	NP_001106860.1	Gene:	Dyrk1a / 13548	MGIID:	1330299	Length:	763	Species:	Mus musculus
Sequence 2:	NP_001369036.1	Gene:	Hipk / 38070	FlyBaseID:	FBgn0035142	Length:	1409	Species:	Drosophila melanogaster

Alignment Length:	965	Identity:	260/965 - (26%)
Similarity:	373/965 - (38%)	Gaps:	278/965 - (28%)

- Green bases have known domain annotations that are detailed below.

Mouse     4 GGETSACKPSSVRLAPSFSFHAAGLQMAAQMPHSHQYSDRRQPSISDQQVSALPYSDQIQQPLTN 68
            ||.:..|           |...|||.:.|    :..|.|:...:.:|    ...:.:|.||.|..
  Fly    20 GGGSGFC-----------SGLGAGLSVRA----TSFYGDQTVTATTD----GTRHQEQQQQQLQQ 65

Mouse    69 QVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRR--------------H 119
            |....|:          |.|||:.... ||....|         :|:||:              |
  Fly    66 QQQQHIL----------RQPATSASTS-SVAAAAT---------SKRKRQTDCDCGCVDSYNSSH 110

Mouse   120 ----QQ-----------------GQGDD---------SSHKK------------ERKVYNDGYDD 142
                ||                 |.|.|         ::|.|            ..|..:.|.|.
  Fly   111 GPPVQQDSSAAAGAGSVGSKAGSGPGPDGIGPISSLKTAHTKVATSGGHANTQPPSKRSSSGADG 175

Mouse   143 DNYDYIVKNGE---KWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEV 204
               ||.:...|   .....||:...:|:|:||||||.:.|...|.|||||:||..::..|.||||
  Fly   176 ---DYQLVQHEVLYSLSAEYEVLEFLGRGTFGQVVKCWKRGTSEIVAIKILKNHPSYARQGQIEV 237

Mouse   205 RLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQM 269
            .:|..:::.:.: ::..|.....|..:||.|||||||..||||.|:...|..:.|...|...:|:
  Fly   238 SILSRLSQENAD-EFNFVRAFECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILEQV 301

Mouse   270 CTALLFLATPELSIIHCDLKPENILLCNPKRS--AIKIVDFGSSCQLGQRIYQ-YIQSRFYRSPE 331
            .||||.|  .:|.:||.|||||||:|.:|.|.  .:|::||||:..:.:.:.. |:|||:||:||
  Fly   302 LTALLKL--KQLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCNTYLQSRYYRAPE 364

Mouse   332 VLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFE 396
            ::||:|:..|||||||||::.|:..|.||:.|::|.||:..|.:..|:|..|:|:.|.|..|||.
  Fly   365 IILGLPFCEAIDMWSLGCVVAELFLGWPLYPGSSEFDQIRYISQTQGLPTEHMLNSASKTSKFFY 429

Mouse   397 KLPDGT---WSLKKTKDGKRE--YKPPGTRK-LHNIL------GVETGGPGGRRAGESGHTVADY 449
            :..|.|   |.||.|::.:.|  .|....|| :.|.|      .|.|...||:...|.    .|.
  Fly   430 RDVDSTYPFWRLKTTEEHEAETNTKSKEARKYIFNCLDDIGQVNVPTDLEGGQLLAEK----TDR 490

Mouse   450 LKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADEGTNTSNSVSTSPAM-----------EQSQ 503
            .:|.||:.|||..|.:.|:.|..||.|||.:.|........|:|..|..|           .|..
  Fly   491 REFIDLLKRMLTIDQERRLTPAEALNHSFTRLTHLVDYVYCNNVKASVQMMEVCRRGDFHTVQPA 555

Mouse   504 SSGTTSSTSSSSGGSSGTSN--------------------------SGR--ARSDP---THQHRH 537
            |:..|:...||:...:.|.|                          :||  ||..|   |...:|
  Fly   556 STLVTNFVPSSTENMTFTINNQLTSQVQRLVRDGRPLAYEGLYQIYNGRSVARQYPQTRTDSFQH 620

Mouse   538 SGGHFAAAVQAMDCETHSPQVRQQFPAP-----LGWSGTEAPTQVTVE----------------- 580
            .      .|..:.|    |...|..|:|     :|.:..:.|.||..:
  Fly   621 Q------LVSNILC----PPSYQTMPSPTKHVVVGSATMQPPLQVPPQQYVNVPVPVSMVEPTSG 675

Mouse   581 -----THPVQ-------ETTFHVA-----PQQNALH-----------------HHHGN------- 604
                 |:.||       :|...:|     |||...|                 .||.|
  Fly   676 QRMLLTNRVQASGVAWPQTGRQMALVPSWPQQAPAHSLIVDSTPLFNVEEIYPKHHLNLPRNDLK 740

Mouse   605 -SSHHHH---------HHHHHHHHHGQQALGNRTRPRVYNSPTNSSSTQDSMEVG---HSHHS-- 654
             .|..||         ..|....|.....:..|.:.   :||.:....|.:..|.   |:||:
  Fly   741 KESPAHHIAKGNSYRVPRHEKKEHQQLSPVKKRVKE---SSPPHQQRYQRAAHVSPQYHAHHNCN 802

Mouse   655 -------MTSLSSSTTSSSTSSSS--TGNQGNQAYQNRPVAANTLDFGQNGAMDVNLTVYSNPRQ 710
                   ..|..|...||:.|||:  .|:..:..:.:.|||     ..|..:......:.||...
  Fly   803 YGNGSGYSASAGSVVASSAASSSNIVNGSSSSSHHHHVPVA-----HAQPYSSSSGHHIVSNCNA 862

Mouse   711 ETGIAGHPTYQFSANTGPAH----YMTEGHLAMRQGADREESPMTGVCVQQSPVA 761
            ..|..|...||    ..|||    :..:.|....|.....:.|...:....||.|
  Fly   863 NGGAGGAVVYQ----QPPAHAHQQHGQQPHPQSSQHPQHVKQPTITIHDTPSPTA 913

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk1a	NP_001106860.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	33..61		3/27 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	115..136		11/76 (14%)
		Bipartite nuclear localization signal. /evidence=ECO:0000255	117..134		9/72 (13%)
		PKc_DYRK1	148..484	CDD:271128	140/353 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	408..442		11/42 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	485..540		18/96 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	596..679		25/130 (19%)
Hipk	NP_001369036.1	STKc_HIPK	192..520	CDD:271113	137/334 (41%)
Hipk	NP_001369036.1	PHA03378	<1080..1327	CDD:223065
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.840