DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment COX10 and CG5037

DIOPT Version :9

Sequence 1:	NP_001294.2	Gene:	COX10 / 1352	HGNCID:	2260	Length:	443	Species:	Homo sapiens
Sequence 2:	NP_609382.1	Gene:	CG5037 / 34394	FlyBaseID:	FBgn0032222	Length:	391	Species:	Drosophila melanogaster

Alignment Length:	294	Identity:	170/294 - (57%)
Similarity:	216/294 - (73%)	Gaps:	10/294 - (3%)

- Green bases have known domain annotations that are detailed below.

Human   151 YDLPG----ILARLSKIKLTALVVSTTAAGFALAPGPFDWPCFLLTSVGTGLASCAANSINQFFE 211
            |.:||    ...:|||.:||:|||.||..|:|:||..||...|.:.::||||.|.|||:|||:.|
  Fly    66 YTMPGKTLSQYKKLSKFRLTSLVVITTMGGYAMAPAAFDPTTFAMCTLGTGLVSAAANAINQYHE 130

Human   212 VPFDSNMNRTKNRPLVRGQISPLLAVSFATCCAVPGVAILTLGVNPLTGALGLFNIFLYTCCYTP 276
            |||||.|:|||||.||.||::||.||:||...|..|:::|..|||.||.|||..|:||||..|||
  Fly   131 VPFDSQMSRTKNRVLVTGQMTPLHAVTFAAVSATAGLSMLYFGVNGLTAALGAGNLFLYTTIYTP 195

Human   277 LKRISIANTWVGAVVGAIPPVMGWTAATGSLDAGAFLLGGILYSWQFPHFNALSWGLREDYSRGG 341
            :|||||.|||||::||||||:|||.....:|||||.:|.|:||:|||||||||||.||.||||.|
  Fly   196 MKRISIVNTWVGSIVGAIPPLMGWAGCAATLDAGAMILAGVLYAWQFPHFNALSWNLRPDYSRAG 260

Human   342 YCMMSVTHPGLCRRVALRHCLALLVLSAAAPVLDITTWTFPIMALPINAYISYLGFRFYVDADRR 406
            |.||:||:||||||.|||:.:|::.|||.|||||:|.:.|.:..||:|||.:||.::|:..:|..
  Fly   261 YRMMAVTNPGLCRRTALRYSVAIVGLSAMAPVLDVTNYWFALETLPLNAYFAYLAYKFHEKSDSG 325

Human   407 SSRRLFFCSLWHLPLLLLLMLTCK------RPSG 434
            |||:||..||.|||.|:||.||.|      :|:|
  Fly   326 SSRKLFRFSLIHLPALMLLFLTNKKEWYFSKPAG 359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
COX10	NP_001294.2	PT_UbiA_Cox10	160..415	CDD:260120	154/254 (61%)
CG5037	NP_609382.1	PT_UbiA_Cox10	78..344	CDD:260120	160/265 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158975
Domainoid	1	1.000	310	1.000	Domainoid score	I1330
eggNOG	1	0.900	-	-		E1_COG0109
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H80170
Inparanoid	1	1.050	341	1.000	Inparanoid score	I2363
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51964
OrthoDB	1	1.010	-	-		D1260807at2759
OrthoFinder	1	1.000	-	-		FOG0004321
OrthoInspector	1	1.000	-	-		oto89684
orthoMCL	1	0.900	-	-		OOG6_101203
Panther	1	1.100	-	-	LDO	PTHR43448
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R239
SonicParanoid	1	1.000	-	-		X3592
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800