DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam and tutl

DIOPT Version :9

Sequence 1:	XP_006522949.1	Gene:	Dscam / 13508	MGIID:	1196281	Length:	2034	Species:	Mus musculus
Sequence 2:	NP_001303307.1	Gene:	tutl / 46015	FlyBaseID:	FBgn0010473	Length:	1536	Species:	Drosophila melanogaster

Alignment Length:	1604	Identity:	347/1604 - (21%)
Similarity:	553/1604 - (34%)	Gaps:	424/1604 - (26%)

- Green bases have known domain annotations that are detailed below.

Mouse   512 NITAIAGRDTYIHCRVIGYPY-----YSIKWYKNANL----LPF--------NHRQVAFE----- 554
            :||||.|.....:|.| .:|.     |.::|.|..:.    ||.        .|.:..::
  Fly   137 HITAILGEGVIFNCHV-EFPNDHPVPYVLQWDKKVSETGSDLPIYIWYESYPEHIEEGYKGRVSR 200

Mouse   555 -------NNGTLKLSDVQKEVDEGEYTCNVLV----QPQLSTSQSVHVTVKVPP--FIQPFEFPR 606
                   .:.:|.|::: :|.|:|.|.|.|:.    ..|.......|:.|..||  .:.|.:...
  Fly   201 VSQDSPFGSASLNLTNI-RESDQGWYECKVVFLNRDPKQHKNGTWFHLDVHAPPRFSVTPEDIIY 264

Mouse   607 FSIGQRVFIPCVVVSGDLPITITWQKDGRPIPASLGVTIDNIDFTSSLRISNLSLMHNGNYTCIA 671
            .::|..:.:.|.......| .|.|.||..|:..|..|.|.| |.| .||||.:.....|.|||||
  Fly   265 VNLGDSIILNCQADGTPTP-EILWYKDANPVDPSPTVGIFN-DGT-ELRISTIRHEDIGEYTCIA 326

Mouse   672 RNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQP 736
            ||....|.|.:::|:......:|.|.:|..:.|:.||.:|.|:..|....|..:.:|:  |..:.
  Fly   327 RNGEGQVSHTARVIIAGGAVIMVPPTNQTKLEGEKVIFSCEAKAMPGNVTVRWYREGS--PVREV 389

Mouse   737 IALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQ 801
            .||..|:.:..:|||:|..:..:|||.|||:|:|.:|...|.|.||:|:.||.:|..|.......
  Fly   390 AALETRVTIRKDGSLIINPIKPDDSGQYLCEVTNGIGDPQSASAYLSVEYPAKVTFTPTVQYLPF 454

Mouse   802 GQRKEMSCTAHGEKPI-IVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPT-VRED-SGFF 863
            .....:.|.......: .|.|.|:.|::.|...:.:|        |::...:|.| |.|: .|.:
  Fly   455 RLAGVVQCYIKSSPQLQYVTWTKDKRLLEPYQMKDIV--------VMANGSLLFTRVNEEHQGQY 511

Mouse   864 SCHAINSYGE--DRGIIQLTVQEPP---------------DPPEIEIKDVKARTI---TLRWTMG 908
            :|...|:.|.  ..|::.:.|::||               |..|:....::|...   |::|.
  Fly   512 ACTPYNAQGTAGASGVMDVLVRKPPAFTVEPETLYQRKVGDSVEMHCDALEAEGTERPTIKWQ-- 574

Mouse   909 FDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSN 973
                          :.:.:....:||.: :.....:.||.::........:....|.:.......
  Fly   575 --------------RQEGEQLTESQRNR-IKISGGNITIENLRREDFGYYQCVVSNEVATLMAVT 624

Mouse   974 EITITADEAAPDGPPQEVHLEPTSSQSIRVTW----KAPKKHLQNGIIRGYQIGYREYSTGGNFQ 1034
            ::.|   |......|..:..:.|.| ||.:.|    ....::.|:     |.|.:||   .|...
  Fly   625 QLVI---EGTQPHAPYNITGKATES-SITLQWLPGYSGGSEYKQD-----YTIWFRE---AGVND 677

Mouse  1035 FNIISIDTTGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIA 1099
            :..||:..:|.::| |::.|...|.|...|...|..|.|..|:.:...||||.|: .|.||:|..
  Fly   678 WQTISVTPSGSTQV-TINGLASGTTYEFQVVGRNVLGDGMMSKVMTVRTLEDAPA-APRNVKAAT 740

Mouse  1100 TSPESISISWSTLSKEALNGILQGFRVIYWANLIDGELGEIKNVTTTQPSLELDGLEKYTNYSIQ 1164
            ..|:|.   :..:..||   .|..:..||:.....|.|      ..:.|.|
  Fly   741 QPPDSF---FQLMPDEA---DLLAYFDIYFHTDSRGTL------VYSPPKL-------------- 779

Mouse  1165 VLAFTRAGDGVRSEQIFTRTKEDVPGPPAGVKAAAASASMVFVSWLPPLKLNGIIRKYTVFCSHP 1229
                              |.|...||||..|.....|...: ::|..||:...|::.||:    .
  Fly   780 ------------------RVKGPKPGPPRNVSVTEVSNGFL-ITWQSPLERAHIVKFYTI----K 821

Mouse  1230 YPT-----VISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPARIL 1289
            |.|     .::..:..|:...|.:.||...|.|...|:|.:.....:|.|:....| |:...:.:
  Fly   822 YRTDAQWKTLNRGQIRPEETQYLVKNLVGGRTYYFRVLANSEKSYESSDEVKFPVP-ARVKHKAI 885

Mouse  1290 TFSGTV--TTPWMKDIVLPCKAVG--DPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVK 1350
            | :|.|  ...::..|:|...||.  :.....|..|:.|.....:| |.|....:|.....|:..
  Fly   886 T-AGVVGGILFFIVAIILSVCAVKICNKRKRRKQEKEFNMVACRIT-DARNIAANNHHLHNRSTG 948

Mouse  1351 AEDSGYYSCVANNNWGSDEI-------ILNLQVQVPPDQPRLTVSKTTSSSITLSWLPGDNGGSS 1408
            :..||.   |....:....|       |..|....|||  |.|...:..||..|.....|:||..
  Fly   949 SISSGQ---VPLKKYKQTRISSLTAILIAILHWIWPPD--RCTNCHSIYSSPNLEDGDEDDGGGG 1008

Mouse  1409 IRGYI--LQYSEDNSEQWGSFPI---SPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEI--- 1465
            .|..:  :|.|.|     |.|.:   ..|:..|..:.|:.|.    ......|:...|.|.:
  Fly  1009 RRRSVSRIQRSLD-----GRFVLDVEGVSKLGYSQQTLESGN----VDVVDGGLFERRNSNVSQK 1064

Mouse  1466 --------------IEAKTLGKEPQFSKEQELFASINTTRVR-----LNLIGWNDGGCPITS--- 1508
                          |.|:...:.|..:...:|.........|     |..||......|..|
  Fly  1065 SSSDDGGFLSRRNFITARASWRRPLVASSSQLSLQSAADSARGFLQGLLKIGAKQSAVPPNSQSY 1129

Mouse  1509 ---------FTLEYRPF--GTTVWTTAQRT----------SLSKSYILY--------------DL 1538
                     :....||:  ...::..|.|:          |||:...||              .|
  Fly  1130 FDEAVSGARYQNVLRPYTSSNNLYGNADRSRPLHINTISGSLSQQQQLYTPSRISRIFSSSPQQL 1194

Mouse  1539 QEATWYELQMRVCNSAGCAEKQANFATLNYDGSTI-PPLIKSVVQSEEGLTT-----NEGLKILV 1597
            |.    ..|..:.:|.|......:|:.|    ||: ||  .|..:|...|::     ::.|..|.
  Fly  1195 QP----HHQQLLLSSGGSGAYPTHFSDL----STVYPP--NSAERSSHNLSSRYRYYSQELPSLR 1249

Mouse  1598 TISCILVGVLLLFVLLLVVRRRRREQRLKRLRDA------------KSLAEMLMSKNTRT----- 1645
            ||.              ...||:::|:...|.|.            :|..:...|...||
  Fly  1250 TIQ--------------EETRRQQQQKQHPLEDHFVPLQLPSPPSWRSYYQSQASYRPRTRWYPR 1300

Mouse  1646 --SDTLSKQQQTLRMHIDIPRAQLLIEERDTMETIDDRSTVLLTDADFGEAAKQKSLTVTHTVHY 1708
              |...|.:||...|...:|  ||.:..|::|
  Fly  1301 HHSRLFSNRQQQHEMLSPLP--QLNLNLRNSM--------------------------------- 1330

Mouse  1709 QSVSQATGPLVDVSDARPGTNPTTRRNAKAGPTARNR---YASQWTLNRPHPTISAHTLTTDWR- 1769
                            .||       ..:|.|.:|:.   :.|:.|.|.|..       |::||
  Fly  1331 ----------------NPG-------GLEASPESRSSSSGFGSKNTSNHPGS-------TSEWRL 1365

Mouse  1770 LPTPRATGSVDKESDSYSVSPSQDTDRARSSMVSTESASSTYEELARAYEHAKMEEQLRHAKFTI 1834
            ||..||..|..|.|..:....:|.         .|...|.:|.....             ..:|:
  Fly  1366 LPPYRAPPSPPKHSGYFGGQQAQG---------QTPHGSYSYPRATT-------------PPYTM 1408

Mouse  1835 TECFISDTSSEQLTAGTNEYTDSLTSSTP------SESGICRFTASPPKPQDGGRV---VNMAVP 1890
            ....       ::.:..|..|||.....|      |..|...|..:.|.|.....:   :|:.:.
  Fly  1409 AHWL-------EMISRLNAATDSNLPKAPCPVDVGSVDGHYEFDPATPTPSASSMLREDLNLHID 1466

Mouse  1891 --KAHRPVLETRSSKSRHQLTHVPL-------RALGDLIHLPPY 1925
              ..|...|...|....|  :|.|.       |:|.  .|||.|
  Fly  1467 THPYHHHTLGPLSGSLLH--SHAPYGGGARKQRSLP--AHLPRY 1506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam	XP_006522949.1	Ig	15..115	CDD:386229
		IGc2	239..300	CDD:197706
		IG	320..400	CDD:214652
		Ig_3	410..488	CDD:372822
		IGc2	518..575	CDD:197706	16/85 (19%)
		Ig	596..686	CDD:386229	31/91 (34%)
		Ig_DSCAM	707..784	CDD:143211	28/76 (37%)
		Ig	802..889	CDD:386229	21/106 (20%)
		FN3	885..978	CDD:238020	12/110 (11%)
		FN3	986..1083	CDD:238020	25/100 (25%)
		FN3	1091..1184	CDD:238020	15/92 (16%)
		FN3	1189..1278	CDD:238020	24/93 (26%)
		Ig_3	1301..1363	CDD:372822	15/63 (24%)
		FN3	1380..1470	CDD:238020	25/111 (23%)
		FN3	1486..1555	CDD:238020	19/111 (17%)
tutl	NP_001303307.1	V-set	137..250	CDD:284989	24/114 (21%)
		IG_like	137..229	CDD:214653	21/93 (23%)
		I-set	253..341	CDD:254352	30/90 (33%)
		IGc2	268..331	CDD:197706	26/65 (40%)
		I-set	346..437	CDD:254352	32/92 (35%)
		Ig	349..437	CDD:299845	32/89 (36%)
		Ig	459..530	CDD:299845	17/78 (22%)
		IG_like	549..628	CDD:214653	10/95 (11%)
		IGc2	551..617	CDD:197706	10/82 (12%)
		FN3	633..725	CDD:238020	25/101 (25%)
		FN3	786..874	CDD:238020	24/92 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10075
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910