DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dscam and dpr15

DIOPT Version :9

Sequence 1:	XP_006522949.1	Gene:	Dscam / 13508	MGIID:	1196281	Length:	2034	Species:	Mus musculus
Sequence 2:	NP_001287299.1	Gene:	dpr15 / 41473	FlyBaseID:	FBgn0037993	Length:	662	Species:	Drosophila melanogaster

Alignment Length:	602	Identity:	106/602 - (17%)
Similarity:	189/602 - (31%)	Gaps:	178/602 - (29%)

- Green bases have known domain annotations that are detailed below.

Mouse   270 RFQKTVTGLLIENSRPSDSGSYVCEVSNRYG-------TAKVIGRLYVKQPLKATISPRKVKSSV 327
            |.|...|.:|  ||..::..::....|.|..       .|:.:.:....:|..|........:..
  Fly    23 RGQAEETSIL--NSNGTNGRAFQRTQSRREALIPATTQMAQTLDKASAFRPTMAAALDAAAPNRS 85

Mouse   328 GSQVSLSCSVTGNEDQELSWYRNGEILNPGKNVRITGLNHANLIMDHMVKSDGGAYQCFVRKDKL 392
            .:.|::: :::.|.||.|               |:|....|||||.:....:..:|:  :.:|..
  Fly    86 SNNVAIN-NISNNGDQRL---------------RLTAALEANLIMSNRNVQEQHSYR--ITQDNA 132

Mouse   393 SAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLVCNVKGTPLPTVTWTLDDDPILKGSGHRISQ 457
            ::   ...:..:||     ||.:   :|:.|:.:.        |..|.|:|.......:..|
  Fly   133 TS---AASIAPNGT-----AFGD---APSIPIGVA--------PATTTTIDPATTTPTTTTR--- 175

Mouse   458 MITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIRPMKNITAIAGRDTY 522
                                     |.|....|...|       :.|.:|...:.|.:.||...|
  Fly   176 -------------------------RTTRRPVATTTL-------KPPPTIDDYQTIISQAGTHAY 208

Mouse   523 IHCRVIGYPYYSIKW--YKNANLLPFNHR--------QVAFENN---GTLKLSDVQKEVDEGEYT 574
            :.|.|.......|.|  .::.::|..:..        |..|..|   .:|::..||.: |||.|.
  Fly   209 LPCNVKQLVKKPISWLRMRDGHILTVDQTTFIADQRFQSVFSPNPERWSLQIKYVQLK-DEGTYE 272

Mouse   575 CNVLVQPQLSTSQSVHVTVKVPPFIQPFEFPR-FSIGQRVFIPCVVVSG-DLPITITW---QKD- 633
            |.|..:|:  .|..||:.:..|......|..| ...|.:|.:.|::... :.|:.|.|   ||.
  Fly   273 CQVSTEPK--ASAIVHLRIVEPKTELIGESTRHVKAGSQVKLRCIISQALEPPLFINWFYNQKQI 335

Mouse   634 -----------------GRPIPASLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQ 681
                             ...:|.:...|.......|:...:..:.....:.|.....|.|.....
  Fly   336 YLHNRRGWRTEIERIDLPAEVPTTSTTTTTTTTTASTTTTTTSTTPATPSTTATGSTEGATSSET 400

Mouse   682 SQLIVRVPPKFVVQPRDQDGI-------------------------------------------- 702
            ...:|.:...:::....|:.:
  Fly   401 LNGLVTITRSYILDAISQNDVSELGAAAGVAVATETSTAQLLTEVEATSSTSGTSTGAGLLASTS 465

Mouse   703 ----YGKAVILNCSAEG----YPVPTIVW------KFSKGAGVPQFQPIALNGRIQVLSNGSLLI 753
                .|.|..:..:|.|    ....|..|      :.:..|.......:..:..|:.::..||:|
  Fly   466 AAYAAGAAAGITTAATGDSAATAATTSAWLTTMDAEAATTAATTTTTMLPSSSFIKQITTASLII 530

Mouse   754 KHVVEEDSGYYLCKVSN 770
            ..||:.|||.|.|..||
  Fly   531 PAVVKLDSGNYTCSPSN 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam	XP_006522949.1	Ig	15..115	CDD:386229
		IGc2	239..300	CDD:197706	8/29 (28%)
		IG	320..400	CDD:214652	14/79 (18%)
		Ig_3	410..488	CDD:372822	11/77 (14%)
		IGc2	518..575	CDD:197706	17/69 (25%)
		Ig	596..686	CDD:386229	17/112 (15%)
		Ig_DSCAM	707..784	CDD:143211	18/74 (24%)
		Ig	802..889	CDD:386229
		FN3	885..978	CDD:238020
		FN3	986..1083	CDD:238020
		FN3	1091..1184	CDD:238020
		FN3	1189..1278	CDD:238020
		Ig_3	1301..1363	CDD:372822
		FN3	1380..1470	CDD:238020
		FN3	1486..1555	CDD:238020
dpr15	NP_001287299.1	IG_like	197..289	CDD:214653	25/94 (27%)
dpr15	NP_001287299.1	V-set	204..290	CDD:284989	23/88 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900