DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam and dpr5

DIOPT Version :9

Sequence 1:	XP_006522949.1	Gene:	Dscam / 13508	MGIID:	1196281	Length:	2034	Species:	Mus musculus
Sequence 2:	NP_650080.3	Gene:	dpr5 / 41381	FlyBaseID:	FBgn0037908	Length:	336	Species:	Drosophila melanogaster

Alignment Length:	219	Identity:	54/219 - (24%)
Similarity:	88/219 - (40%)	Gaps:	48/219 - (21%)

- Green bases have known domain annotations that are detailed below.

Mouse   511 KNITAIAGRDTYIHCRVIGYPYYSIKWYKNANL-------------LPFNHRQVAFENNGTLKLS 562
            :.:.|..|....:||||......::.|.:..:|             ..|..|.:...:...||:.
  Fly    98 REVIAALGTTARLHCRVRHLGDRAVSWIRQRDLHILTIGIMTYTNDQRFLARHIDNSDEWVLKIV 162

Mouse   563 DVQKEVDEGEYTCNVLVQPQLSTS-QSVHVTVKV------PPFIQPFEFPRFSIGQRVFIPCVVV 620
            .||:. |.|.|.|.|..:|::|.: :.|.||.|.      ..|||.        |..:.:.|:..
  Fly   163 SVQQR-DAGVYECQVSTEPKISLAYKLVVVTSKAQILANRELFIQS--------GSDINLTCIAP 218

Mouse   621 SGDLPIT-ITWQKDGRPIPASL--GVTIDNID--FTSSLRISNLSLMHNGNYTCIARN------- 673
            ....|.| :.|.||...:..|.  |:.:::..  .||:|.||.:....:|||||.|.|
  Fly   219 QAPGPYTHMLWHKDTELVSDSARGGIRVESEQQMKTSNLVISRVQHTDSGNYTCSADNSNSDSVF 283

Mouse   674 -------EAAAVEHQSQLIVRVPP 690
                   :.||::|:....:.:||
  Fly   284 VHIIKSEQHAAMQHELGSRLLLPP 307

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam	XP_006522949.1	Ig	15..115	CDD:386229
		IGc2	239..300	CDD:197706
		IG	320..400	CDD:214652
		Ig_3	410..488	CDD:372822
		IGc2	518..575	CDD:197706	16/69 (23%)
		Ig	596..686	CDD:386229	27/108 (25%)
		Ig_DSCAM	707..784	CDD:143211
		Ig	802..889	CDD:386229
		FN3	885..978	CDD:238020
		FN3	986..1083	CDD:238020
		FN3	1091..1184	CDD:238020
		FN3	1189..1278	CDD:238020
		Ig_3	1301..1363	CDD:372822
		FN3	1380..1470	CDD:238020
		FN3	1486..1555	CDD:238020
dpr5	NP_650080.3	V-set	95..191	CDD:284989	22/93 (24%)
		IG_like	98..179	CDD:214653	19/81 (23%)
		IG_like	206..278	CDD:214653	22/79 (28%)
		Ig	211..278	CDD:143165	20/66 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900