DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam and Cont

DIOPT Version :9

Sequence 1:	XP_006522949.1	Gene:	Dscam / 13508	MGIID:	1196281	Length:	2034	Species:	Mus musculus
Sequence 2:	NP_649461.2	Gene:	Cont / 40553	FlyBaseID:	FBgn0037240	Length:	1390	Species:	Drosophila melanogaster

Alignment Length:	1338	Identity:	279/1338 - (20%)
Similarity:	457/1338 - (34%)	Gaps:	391/1338 - (29%)

- Green bases have known domain annotations that are detailed below.

Mouse    95 IHDNTYYCTAENPSGKIRSQDVHIKAVLREPYTVRVEDQKTMRGNVAVFKCIIPSSVEAYVTVVS 159
            :|||.:....:..:..|.:.:....::   |.||...:|..:||.:...:   |.....||
  Fly   241 LHDNRFLVQNDLNNQNINNPNQFYNSL---PGTVNQRNQNNLRGFIGPNQ---PYGDNRYV---- 295

Mouse   160 WEKDTVSLVSGSR---------------FLITSTGALYIKDVQN----EDGLYNY-------RCI 198
              :|.|......:               ..|..:..||..|..|    :...|:|       ..|
  Fly   296 --RDRVVYAFSKKRDRWMFMPAYEIELNLFICESKVLYSSDNVNIKLDDKRPYHYGLDINDMERI 358

Mouse   199 TRHRYTGETRQSNSARLFVSDPANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNM 263
            .|..|            ||..|.::.      ||..|......|.|.|.|.|:|.|.|.|.::
  Fly   359 PRGPY------------FVKQPNDTT------FDVNKNRLINDVTLSCLANGYPTPSYTWYRE-- 403

Mouse   264 PLELSGR--FQK---------TVTG---LLIENSRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPL 314
             :.:..|  :||         |::|   ::.|..:..|.|:|.|...|::|..:
  Fly   404 -VYVDDRLEYQKIDPLAQDRYTISGGNLIIYEPKQALDQGAYHCVAENKFGRIR----------- 456

Mouse   315 KATISPRKVKSSVGSQVSLSCSVTGN-----EDQELSWYRNGEILNPGKNVRITGLNH------- 367
                       |..:.::....:..|     |..|::|         ||::......|
  Fly   457 -----------SESAHLNFGFIMEFNLKRSAETSEMNW---------GKSIFCDPPQHYPDVRYY 501

Mouse   368 ------ANLIMDH---MVKSDGGAYQCFVRK-DKLSAQDYVQVVLEDG-----------TPK--- 408
                  .|.:.:.   .|..||..|..|:.. |:.:....||.::.|.           ||.
  Fly   502 WARDYFPNFVEEDQRVFVSRDGALYFSFIETVDRANYSCTVQTLVSDTGRNGPFFPLRVTPNSNY 566

Mouse   409 --IISAFSEKVVSPAEPVS-----LVCNVKGTPLPTVTWTLDDDPILKGSGHRISQMITSEGNVV 466
              :|.|.:...|.|..||:     |.|...|.|:|:..||....| |:.:.:.|:.     |.|
  Fly   567 QALIFANTFPKVFPEAPVAGDEIRLECMAFGYPIPSYNWTRQGLP-LQRNAYTINY-----GRV- 624

Mouse   467 SYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVR-GPASIRPMKNITAIAGRDTYIHCRVIGY 530
              |.|.::...|.|.|.||..|....::....||:: .|....|:|::......|....|.....
  Fly   625 --LIIQNATTNDNGEYSCTITNPRKTLMKSIYINIQMRPQFTIPLKDMIKDYNSDVTFICEAFAI 687

Mouse   531 PYYSIKWYKNANLL-PFN---HRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHV 591
            |..:..|||||..| |.|   .|.:..:|..|:|.  ::|:.|:..|.|.  .|.||.||
  Fly   688 PDANYTWYKNAERLDPANINRDRYIIQDNVLTIKF--LEKDKDDAMYQCG--AQNQLKTS----- 743

Mouse   592 TVKVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPASLGVTIDNIDFTSSLRI 656
                           ||..|                                          ||:
  Fly   744 ---------------FSSAQ------------------------------------------LRV 751

Mouse   657 SNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQD--GIYGKAVILNCSAEGYPVP 719
            .::.                             |.|...|.:.:  .:|.....:.|..|..|.|
  Fly   752 LSMK-----------------------------PSFKKHPLESEVYAVYNGNTTIVCDPEAAPRP 787

Mouse   720 TIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTV 784
            ...||       ...|.|...|..::|.:|:|.|.....:|.|.|.|..||..|.|.|.:..:.:
  Fly   788 KFQWK-------KDGQVIGSGGHRRILPSGTLTISPTSRDDEGIYTCIASNQAGTDESHARVIVL 845

Mouse   785 KIPAMITSYPNTTLATQGQRKEMSCTAHGEK--PIIVRWEKEDRII---NPEMARYLVSTKEVGE 844
            :....|.:.|...::.:.....:.|.|..::  .|...|:....::   :....|.:|..
  Fly   846 QEIRFIETPPQRIVSKEHDLIFLHCEAAFDELLDIAYVWKHNGEVLKNNHDGTGRIIVDW----- 905

Mouse   845 EVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPP----EIEIKDVKARTITLRW 905
               :.|.:..|...|:|.:.|...::..|......::::..|..|    .|:|...||   .:.|
  Fly   906 ---NRLTVHNTSMRDAGDYECVVKSAVNEISSKTSVSIEGAPGAPGGVQVIQISKTKA---IIEW 964

Mouse   906 TMGFDGNSPITGYDIECK-NKSDSWDSAQ-----RTKDVSPQLNSATIIDIHPSSTYSIRMYAKN 964
            ..|......|..|:|..: |.:.:|.:..     |..|.......|.::::.|.|.|...:.|.|
  Fly   965 VDGSHNGRAIRYYNILGRTNWNRTWVNVSTHVQAREVDRYTSRQQAEVVNLTPWSAYEFSVTAVN 1029

Mouse   965 RIGKSEPS---------------------------NEITITADEAAPDGPPQEVHLEPTSSQSI- 1001
            .:|...||                           .::|||.|...    |||.|     |..|
  Fly  1030 DLGIGTPSAPSPIYSTYEDKPYIAPRNVGGGGGKIGDLTITWDPLL----PQEQH-----SHGIH 1085

Mouse  1002 -RVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISIDTTGDSEVYTLDNL----------N 1055
             :|.||          ::|                   :|:...| |:...|::          |
  Fly  1086 YKVFWK----------LKG-------------------AIEWASD-EIKKQDHMGVAVVNIPLNN 1120

Mouse  1056 KFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSPESISISWS--TLSKEALN 1118
            .:|:|.:.|||.|..|.||.|:..:..:.||:|...|:...|:|.:....:::|.  .:|:|.:.
  Fly  1121 YYTEYEVKVQAINSVGKGPESEIAVIHSAEDMPQVAPQKPIALAYNSTCFNVTWQPIDMSRENIR 1185

Mouse  1119 GILQGFRVIYWANLIDGELGEIKNVTTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTR 1183
            |.|.|.|:.||......|........||:....:.||:..|.|.::|:|:..||:|..||:...|
  Fly  1186 GKLIGHRLKYWKTTHQEEDSVYYLSRTTRNWALIVGLQPDTYYFVKVMAYNAAGEGPESERFEER 1250

Mouse  1184 TKEDVP-GPPAGVKAAAASASMVFVSW--LPPLKLNGIIRKYTV----------FCSHPYPTVIS 1235
            |....| .||:.|.....:.|.|.|.|  :.|.:....:..|.|          ..::....:..
  Fly  1251 TYRKAPQKPPSSVHVYGINPSTVRVVWRYVSPSQDEEPVEGYKVRIWESDQNMITANNTIVPIGQ 1315

Mouse  1236 EFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSS 1273
            :.|      || |.||:..:.|::.|:|.::.|.|..|
  Fly  1316 KLE------SY-INNLTPGKSYNMRVLAYSNGGDGRMS 1346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam	XP_006522949.1	Ig	15..115	CDD:386229	4/19 (21%)
		IGc2	239..300	CDD:197706	20/74 (27%)
		IG	320..400	CDD:214652	16/101 (16%)
		Ig_3	410..488	CDD:372822	25/82 (30%)
		IGc2	518..575	CDD:197706	18/60 (30%)
		Ig	596..686	CDD:386229	5/89 (6%)
		Ig_DSCAM	707..784	CDD:143211	22/76 (29%)
		Ig	802..889	CDD:386229	13/91 (14%)
		FN3	885..978	CDD:238020	25/129 (19%)
		FN3	986..1083	CDD:238020	25/108 (23%)
		FN3	1091..1184	CDD:238020	26/94 (28%)
		FN3	1189..1278	CDD:238020	23/98 (23%)
		Ig_3	1301..1363	CDD:372822
		FN3	1380..1470	CDD:238020
		FN3	1486..1555	CDD:238020
Cont	NP_649461.2	CLECT	139..>223	CDD:214480
		Ig	361..460	CDD:299845	29/141 (21%)
		I-set	362..462	CDD:254352	29/142 (20%)
		Ig	466..559	CDD:299845	17/101 (17%)
		IG_like	584..657	CDD:214653	22/81 (27%)
		IGc2	586..645	CDD:197706	19/67 (28%)
		Ig	667..751	CDD:299845	29/149 (19%)
		IG_like	676..751	CDD:214653	28/140 (20%)
		IG_like	765..844	CDD:214653	23/85 (27%)
		Ig	773..844	CDD:299845	22/77 (29%)
		I-set	851..940	CDD:254352	14/96 (15%)
		Ig	866..944	CDD:299845	12/85 (14%)
		FN3	944..1043	CDD:238020	24/101 (24%)
		FN3	1053..1146	CDD:238020	29/131 (22%)
		fn3	1156..1244	CDD:278470	24/87 (28%)
		fn3	1259..1346	CDD:278470	21/93 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10075
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100