DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam and Dscam2

DIOPT Version :9

Sequence 1:	XP_006522949.1	Gene:	Dscam / 13508	MGIID:	1196281	Length:	2034	Species:	Mus musculus
Sequence 2:	NP_001261500.1	Gene:	Dscam2 / 38788	FlyBaseID:	FBgn0265296	Length:	2101	Species:	Drosophila melanogaster

Alignment Length:	2161	Identity:	664/2161 - (30%)
Similarity:	1032/2161 - (47%)	Gaps:	227/2161 - (10%)

- Green bases have known domain annotations that are detailed below.

Mouse     1 MWI----LALSLFQSFANVFSEEPHSSLY---FVNASLQEVVFASTSGTLVPCPAAGIPPVTLRW 58
            |||    ..:.|..:..|..||...:.|.   ||......|.|:::||..:.|.|:|.|..|:.|
  Fly     1 MWISSRFFVILLLLNLDNTCSEPFEAHLRGPGFVMEPPGRVEFSNSSGGWLDCSASGSPQPTVDW 65

Mouse    59 YLATGEEIYDVPGIRHVHPNGTLQIFPFPPSSFSTLIHDNTYYCTAENPSGKIRSQDVHIKAVLR 123
            ..|.|..:.::.|:|.|..||||.:.||..:::...:|:..|.|.|.|..|:|.|:||.::||:.
  Fly    66 VHADGSAVTEIHGVRRVLRNGTLVLMPFAAAAYHQDVHNTIYRCIASNSVGRIVSRDVQVRAVVA 130

Mouse   124 EPYTVRVEDQKTMRGNVAVFKCIIPSSVEAYVTVVSWEKDTV-----SLVSGSRFLITSTGALYI 183
            :.|.|.||.....||..|:.:|::|:.|:..|.||||..:..     ||....:|.:..||.|.|
  Fly   131 QAYKVDVEVLSAARGCTAILRCVVPTFVKELVRVVSWVHEPAIYIYPSLQGDGKFHLLPTGELLI 195

Mouse   184 KDVQNEDGLYNYRCITRHRYTGETRQSNSARLFVSDPANS-----APSILDGFDHRKAMAGQRVE 243
            .::|..|...::||.:.||.|.:...|:..||.:    ||     :||:::...|.:....:...
  Fly   196 HNLQESDESQSFRCRSMHRLTRQVVVSSPTRLRI----NSHRGIISPSVVEHTAHVQVSQDEGAV 256

Mouse   244 LPCKALGHPEPDYRWLKDN----MPLELSG-RFQKTVTGLLIENSRPSDSGSYVCEVSNRYGTAK 303
            |.|.|.|.|.|:|.|...|    :|: ||| |.:.....|.||.....|||.|.|...|..|.|.
  Fly   257 LLCVAQGCPSPEYSWFTHNGAGPLPV-LSGPRVRLLGPILAIEAVTGEDSGVYKCTAGNVGGEAS 320

Mouse   304 VIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGNED----QELSWYRNGEILNPGKNVRITG 364
            ...||.|..|::..|||..:...:|......|.||.|..    |.:.||::|..|.....|..|
  Fly   321 AELRLTVATPIQVEISPNVLSVHMGGTAEFRCLVTSNGSPVGMQNILWYKDGRQLPSSGRVEDT- 384

Mouse   365 LNHANLIMDHMVKSDGGAYQCFVRK---DKLSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSL 426
                 |::..:.:.:.|.|||.||:   |...|...:|  |.|..|.::.:|.|:.:.|...|||
  Fly   385 -----LVVPRVSRENRGMYQCVVRRPEGDTFQATAELQ--LGDAPPVLLYSFIEQTLQPGPAVSL 442

Mouse   427 VCNVKGTPLPTVTWTLDDDPILKGSGHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAG 491
            .|:..|.|.|.::||||..|:.......|.|.||..|:|:|::|||...|.|||.|.|.|.|.||
  Fly   443 KCSAAGNPTPQISWTLDGFPLPSNGRFMIGQYITVHGDVISHVNISHVMVEDGGEYACIAENRAG 507

Mouse   492 VVLYQARINVRGPASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNANLLPFNHRQVAFENN 556
            .|.:.||:|:.|...||.:..:||::|....:.|.|.|||...|.|.:....||.:.|| ..:.:
  Fly   508 RVQHAARLNIYGLPYIRLIPKVTAVSGETLNLKCPVAGYPIEEIHWERGGRELPDDIRQ-RVQPD 571

Mouse   557 GTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFE--FPRFSIGQRVFIPCVV 619
            |:|.:|.|||..|.|.|||....:...|..:|..|||.|||.:.||:  ..:.::|.|..:.|.|
  Fly   572 GSLTISPVQKNSDSGVYTCWARNKQGHSARRSGEVTVIVPPKLSPFQTNILQLNMGDRASLTCSV 636

Mouse   620 VSGDLPITITWQKDGRPIPASLGVTIDNID-FTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQ 683
            |.||||:||.|:||||||..:..:::..:| :.|.|.|.||...|.|||:|:.||.||.||:...
  Fly   637 VKGDLPLTINWRKDGRPIDPTQHMSVKQVDQYNSILVIENLGSDHTGNYSCVVRNSAAEVENSQA 701

Mouse   684 LIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSN 748
            |:|.|||:::|:|.|.:....:.::|:|.|:|.|.|:||||.:.|:...:::.:......::|.|
  Fly   702 LLVNVPPRWIVEPVDANVERNRHIMLHCQAQGVPTPSIVWKKATGSKSGEYEEVRERPFTKLLGN 766

Mouse   749 GSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQRKEMSCTAHG 813
            ||||::||.|:..|:|||:.:|.:|..:.|.:.|.|......:|...:.:..:|....:.|...|
  Fly   767 GSLLLQHVKEDREGFYLCQANNGIGTGIGKVIQLKVNSSPYFSSTSRSVMVKKGDTALLQCAVSG 831

Mouse   814 EKPIIVRWEKEDR-IINPEMARYLVSTKE--VGEEVISTLQILPTVREDSGFFSCHAINSYGEDR 875
            :|||.:.|.:..: .:||. ..|.:|.|:  ..:.|.:.|||......|||.:.|.|.|.||.|:
  Fly   832 DKPINIVWMRSGKNTLNPS-TNYKISVKQEATPDGVSAELQIRTVDATDSGPYFCRASNLYGNDQ 895

Mouse   876 GIIQLTVQEPPDPPEI-EIKDVKARTITLRWTMGFDGNSPITGYDIECKNKS---------DSWD 930
            .::||.|||||.||.: |...:.:|::.::|.....|...:|.|.:|.:...         |.|.
  Fly   896 QLVQLQVQEPPLPPSVLEAAMISSRSVNIKWQPKTLGTGDVTKYIVEFREADHSLPPALFVDQWQ 960

Mouse   931 SAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNEITITADEAAPDGPPQEVHLEP 995
            ..: .|| .|..| |.|.::.|::.|:.|:.|:...|:|.||.|:.:..:...|.|||..:...|
  Fly   961 QIE-VKD-PPHFN-AMIENLKPATRYAFRVIAEGSAGRSAPSQELIVRTEPQRPAGPPLSLSARP 1022

Mouse   996 TSSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISIDTTGD--SEVYTLDNLNKFT 1058
            .||..:.::|.||...|::|.|:||.:||: .|:.||..:|..|:...||  :....|..|.||.
  Fly  1023 LSSTELLISWVAPLPELRHGDIQGYNVGYK-LSSSGNTAYNFTSVSGDGDGGNGELLLSGLAKFA 1086

Mouse  1059 QYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQG 1123
            :|.:||||.|:.|.||.|:.....|:|||||.|||:|:..|.|.:|:.:||........||:|||
  Fly  1087 RYTVVVQAFNQVGPGPLSEPTAAQTMEDVPSRPPEDVRCAALSSQSLQVSWQPPPIYHTNGLLQG 1151

Mouse  1124 FRVIYWANLIDG---ELGEIKNVTTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTK 1185
            :::|: ..:||.   ...|:::..||..::.|.||.|||||||||||.||.||||.|:.:|..::
  Fly  1152 YKLIF-EPIIDDIQPSKDEVESRKTTALTMVLTGLRKYTNYSIQVLAHTRMGDGVVSKPLFCHSE 1215

Mouse  1186 EDVPGPPAGVKAAAASASMVFVSWLPPLKLNGIIRKYTVFCSHPYPTVI-------SEFEASPDS 1243
            ||||..||.:|..::|:..:::|||||.:.||:|.||::     |..|:       :|..:.|..
  Fly  1216 EDVPEAPADIKVVSSSSQSLYISWLPPNEPNGVITKYSL-----YTRVVNGREELNNEKRSLPSQ 1275

Mouse  1244 FS-YRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPWMKDIVLPC 1307
            .: |....|..:.:|..||.|.|..|.|.||.:.:.....:.||||::|.|.|..||...:.|||
  Fly  1276 QAYYEAKGLHPHMEYQFWVTASTRVGEGKSSRVSSQITTNRIPARIISFGGPVVRPWRSTVTLPC 1340

Mouse  1308 KAVGDPSPAVKWMKD-----SNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCVANNNWGS 1367
            .|||.|..  :|.|.     ..|..:...:|       :|..||.:::..|.|.|||..:|..|:
  Fly  1341 TAVGKPKR--EWFKSDVALRQGGLHNSQLLD-------SGDLIISSLQLADGGNYSCQVDNGIGT 1396

Mouse  1368 DEIILNLQVQVPPDQPRLTVSKTTSSSITLSWLPGDNGGSSIRGYILQYSEDNSEQWGSFPISPS 1432
            |.:...|.|||||..|.|.|:..|||||.:.|..|..|.:.|.||.|.|...|... ....:|..
  Fly  1397 DRLTHTLIVQVPPTAPVLYVTSATSSSILMHWKCGFTGNAPITGYTLFYRRANGNT-DEMQLSRH 1460

Mouse  1433 ERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQFSKEQELFASINTTRVRLNLI 1497
            ..|:.|:.|.||:.|:..|:|||.||....|.|:..:|.|:.|.......|.|. |:|.:.:.|.
  Fly  1461 ASSHELKGLMCGSTYQIHLSAQNKVGTSPTSTILHVRTQGQSPGHPASTALLAP-NSTSLLVRLH 1524

Mouse  1498 GWNDGGCPITSFTLEYRPF---GTTVWT-TAQRTSLSKSYILYDLQEATWYELQMRVCNSAGCAE 1558
            .|.|.|||:..|.|:||..   ....|. .:......:..::.:||.:|.|:|:|...|.||.::
  Fly  1525 SWPDNGCPLLYFVLQYRAVTDDPDAEWVLVSNALKPQRRIVINNLQPSTLYQLRMEAHNVAGISQ 1589

Mouse  1559 KQANFATLNYDGSTIPPLIKSVVQSEEGLTTNEGLKILVTISCILVGVLLLFVLLLVVRRRRREQ 1623
            .:.||.||..||...||.|....:|.:.......:.:|:.....:.|:....::::|..|.
  Fly  1590 AEFNFVTLTKDGDPPPPEIMHRGRSGQTTVIFANINLLIPTIAAVSGMFCTIIMIIVCYRH---- 1650

Mouse  1624 RLKRLRDAKSLAEM-LMSKNTRTSDTLSKQQQTLRMHIDIPRAQLLIEER--DTMETIDDRSTVL 1685
               .|::|..|||. .:.|.:..:...|:..|..|.:..|.:..:...::  :|.|.|...:|..
  Fly  1651 ---MLKNAPPLAEQSQIQKESLENRANSEAAQRERYYATIHKVSMQNNDKIPETSEDISPYATFQ 1712

Mouse  1686 LTDADFGEAAKQ----KSLTVTHTVHYQSVSQATGPLVDVSDARPGTNPTTRRNA-KAGPTARNR 1745
            |::|. |..::.    .:.|:.|:..|...:.|.|    .|...|..:...||:: |..|.:...
  Fly  1713 LSEAG-GNMSQPHHGGPANTLLHSFMYHERALAEG----CSSPPPAASKNRRRHSRKTEPESEES 1772

Mouse  1746 YASQWTLNRPHPTISAHTLTTDWRLPTPRATGSVDKESDSYSVSPSQDTDRARSSMVSTESASST 1810
            .:.|                              |:.:.|.:.|.:|...:.:.|::...:.|||
  Fly  1773 ESDQ------------------------------DQLTSSRTESSNQHEGKIKHSIIYHGAQSST 1807

Mouse  1811 YEELARAYEHAKM---------EEQLRHAKFTITECFISDTSSEQLTAGTNEYTDSLTSSTPSES 1866
            ..:|:...|...:         .:|.:.:..|......|:..:...|:.||. |.:.|::|||.|
  Fly  1808 SSDLSPMSEQKSLPRRGRSRYHHQQYQFSTNTTPRHHNSNKMNNNTTSNTNT-TATNTTATPSTS 1871

Mouse  1867 -----------GICRFTASPPKPQDGGRVVNMAVP--------------KAHRPVLETRSSKSRH 1906
                       |..:..:|..|.||.   :...:|              :.|:..|:..|:.:..
  Fly  1872 SNSNKILSPRGGNLKSISSTFKSQDS---IQCHIPTLVKSPSISTQQQKQFHKQQLQNSSTNNSQ 1933

Mouse  1907 QLTHVP----LRALGDLIHLPPYLRMDF----LLNRGAPGTSRDLSLGQACLEPQKS-RTLKRPT 1962
            ..:..|    |:....|:..|...:::.    ||.....|.|..:    ||:.|... |.:...:
  Fly  1934 HSSSNPNSSSLKQQQPLLITPKLHQLEANGQELLGLDGIGNSPLV----ACMPPSSQFRPIPHKS 1994

Mouse  1963 VL---EPTPMEASSSTSSTREGQQSWQQG-----------------AVATLPQREGAELGQAAKM 2007
            ::   || |...:.|..|....||..||.                 ...|||: :.|. |.:..:
  Fly  1995 IMPAHEP-PHHHNHSQQSHPHQQQQQQQHPGTLLNPSTAMLSSKFFTAPTLPKXDTAN-GGSEYV 2057

Mouse  2008 SSSQESLLDSRGHLKG 2023
            ..:.|: :|..|:..|
  Fly  2058 GGAMEA-MDGFGYDSG 2072

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam	XP_006522949.1	Ig	15..115	CDD:386229	34/102 (33%)
		IGc2	239..300	CDD:197706	23/65 (35%)
		IG	320..400	CDD:214652	22/86 (26%)
		Ig_3	410..488	CDD:372822	32/77 (42%)
		IGc2	518..575	CDD:197706	21/56 (38%)
		Ig	596..686	CDD:386229	40/92 (43%)
		Ig_DSCAM	707..784	CDD:143211	28/76 (37%)
		Ig	802..889	CDD:386229	32/89 (36%)
		FN3	885..978	CDD:238020	28/102 (27%)
		FN3	986..1083	CDD:238020	37/98 (38%)
		FN3	1091..1184	CDD:238020	42/95 (44%)
		FN3	1189..1278	CDD:238020	30/96 (31%)
		Ig_3	1301..1363	CDD:372822	19/66 (29%)
		FN3	1380..1470	CDD:238020	33/89 (37%)
		FN3	1486..1555	CDD:238020	20/72 (28%)
Dscam2	NP_001261500.1	Ig	51..127	CDD:299845	27/75 (36%)
		Ig	138..>203	CDD:299845	20/64 (31%)
		I-set	238..327	CDD:254352	30/89 (34%)
		Ig	247..327	CDD:299845	27/80 (34%)
		I-set	332..418	CDD:254352	25/93 (27%)
		IGc2	344..407	CDD:197706	19/68 (28%)
		IG_like	432..517	CDD:214653	36/84 (43%)
		IGc2	436..507	CDD:197706	31/70 (44%)
		I-set	521..610	CDD:254352	32/89 (36%)
		IGc2	533..597	CDD:197706	23/64 (36%)
		Ig	630..699	CDD:143165	33/68 (49%)
		IG_like	714..802	CDD:214653	30/87 (34%)
		Ig	725..802	CDD:299845	28/76 (37%)
		Ig	823..894	CDD:143165	23/71 (32%)
		FN3	906..1006	CDD:238020	27/102 (26%)
		FN3	1013..1111	CDD:238020	37/98 (38%)
		FN3	1119..1209	CDD:238020	41/90 (46%)
		FN3	1219..1313	CDD:238020	30/98 (31%)
		Ig	1336..1402	CDD:143165	22/74 (30%)
		FN3	1409..1498	CDD:238020	33/89 (37%)
		FN3	1515..1588	CDD:238020	22/72 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	136	1.000	Domainoid score	I4889
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	968	1.000	Inparanoid score	I323
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47134
OrthoDB	1	1.010	-	-		D10185at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8769
orthoMCL	1	0.900	-	-		OOG6_101656
Panther	1	1.100	-	-	O	PTHR10075
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1391
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.840