DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dscam and CG13506

DIOPT Version :9

Sequence 1:	XP_006522949.1	Gene:	Dscam / 13508	MGIID:	1196281	Length:	2034	Species:	Mus musculus
Sequence 2:	NP_001286718.1	Gene:	CG13506 / 37556	FlyBaseID:	FBgn0034723	Length:	503	Species:	Drosophila melanogaster

Alignment Length:	405	Identity:	84/405 - (20%)
Similarity:	146/405 - (36%)	Gaps:	132/405 - (32%)

- Green bases have known domain annotations that are detailed below.

Mouse   513 ITAIAGRDTYIHCRVIGYPY-YSIKWYKNANLL-----PFNHRQVAFENNGTLKLSDVQKEVDEG 571
            :.|..|.|..::|....:.. .::.||||..::     |.:.|.....||..| |.:|..| |..
  Fly    79 VEAKPGDDVILNCDARNFQLSNAVVWYKNRIIIANGQNPISQRVQCMLNNSIL-LRNVSPE-DSD 141

Mouse   572 EYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPC----------VVVSGD--- 623
            :|.|.:|  ||....   |..::|              |.|:.|.|          ....||
  Fly   142 DYYCEIL--PQRVRQ---HTALRV--------------GARLSILCDDRDITDRSQTFRQGDHHK 187

Mouse   624 ------LP--ITITW---QKDGRP--IPASLGVTI-DNIDFTSSLRISNLSLMHNGNYTCIARNE 674
                  ||  .||.|   ..:|:|  :....||.| ||:|..::           |:|.|:|.:.
  Fly   188 LECRTYLPDNATIKWSFNDLNGQPSSVDNQNGVIILDNVDEKNA-----------GDYQCLADDG 241

Mouse   675 AAAVEHQS-QLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIA 738
            :....|.: .:.|:..|.......:.:...|....|.|:....|:
  Fly   242 SRHPPHGTVHIDVQYSPIVSTHRHNVNTEKGATAELYCNYRAKPI-------------------- 286

Mouse   739 LNGRIQVLSNG----------------------SLLIKHVVEEDSGYYLCKVSNDVGADVSKSMY 781
              ||...:.:|                      :|:::.|.:.|.|.|||:|.|.:|::
  Fly   287 --GRSYFIKDGKTLQLSDKYSLKDSVHNDHNRTTLIVREVTDSDLGEYLCQVENAIGSN------ 343

Mouse   782 LTVKIPAMITSYPNTTLATQGQRKEMSCTAHGEKPIIVRW-EKEDRIINPEMARYLVSTKEVGEE 845
               ::...::..|.|.     |.::|  |..|.| :.:.| .:..::::..|..|.::    |..
  Fly   344 ---EVKVHVSYNPETP-----QFEDM--TVEGNK-VTLHWLVRSHQLLSEAMLDYQLT----GSY 393

Mouse   846 VISTLQILPTVREDS 860
            ..||:|:|.|.|.::
  Fly   394 TWSTVQVLETHRHNN 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam	XP_006522949.1	Ig	15..115	CDD:386229
		IGc2	239..300	CDD:197706
		IG	320..400	CDD:214652
		Ig_3	410..488	CDD:372822
		IGc2	518..575	CDD:197706	17/62 (27%)
		Ig	596..686	CDD:386229	24/117 (21%)
		Ig_DSCAM	707..784	CDD:143211	16/98 (16%)
		Ig	802..889	CDD:386229	15/60 (25%)
		FN3	885..978	CDD:238020
		FN3	986..1083	CDD:238020
		FN3	1091..1184	CDD:238020
		FN3	1189..1278	CDD:238020
		Ig_3	1301..1363	CDD:372822
		FN3	1380..1470	CDD:238020
		FN3	1486..1555	CDD:238020
CG13506	NP_001286718.1	IG_like	79..146	CDD:214653	18/68 (26%)
		IGc2	83..146	CDD:197706	17/64 (27%)
		IG_like	176..254	CDD:214653	20/88 (23%)
		Ig	176..239	CDD:299845	18/73 (25%)
		I-set	258..349	CDD:254352	18/121 (15%)
		Ig	275..348	CDD:143165	16/103 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900