DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dscam and Lac

DIOPT Version :9

Sequence 1:	XP_006522949.1	Gene:	Dscam / 13508	MGIID:	1196281	Length:	2034	Species:	Mus musculus
Sequence 2:	NP_523713.2	Gene:	Lac / 36363	FlyBaseID:	FBgn0010238	Length:	359	Species:	Drosophila melanogaster

Alignment Length:	397	Identity:	85/397 - (21%)
Similarity:	139/397 - (35%)	Gaps:	123/397 - (30%)

- Green bases have known domain annotations that are detailed below.

Mouse   123 REPYTVRVEDQKTMR--GNVAVFKCIIPSSVEAYVTVVSWEKDTVSLVSGSRFLI---------- 175
            |.| |:....|:.::  |....|.|.:..:.|..|..:..:.|.|.|.:||..:|
  Fly    27 RTP-TISYITQEQIKDIGGTVEFDCSVQYAKEYNVLFLKTDSDPVFLSTGSTLVIKDSRFSLRYD 90

Mouse   176 --TSTGALYIKDVQNED-GLYNYRCI--TRHRYTGETRQSNSARLFVSDPANSAPSILDGFDHRK 235
              :||..|.|||:|..| |.|..:.:  |.|:.:.|.:.|......:||  ||..|::
  Fly    91 PNSSTYKLQIKDIQETDAGTYTCQVVISTVHKVSAEVKLSVRRPPVISD--NSTQSVV------- 146

Mouse   236 AMAGQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTVTGLLIENSRPSDSGSYVCEVSNRYG 300
            |..|..|::.|.|.|:|.|...|.::|..:                  .|:||.:||
  Fly   147 ASEGSEVQMECYASGYPTPTITWRRENNAI------------------LPTDSATYV-------- 185

Mouse   301 TAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGNEDQELSWYRNGEILNPGKNVRITGL 365
                                                                    |..:||..:
  Fly   186 --------------------------------------------------------GNTLRIKSV 194

Mouse   366 NHANLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKIISAFSEKVVSPAE-PVSLVCN 429
            .          |.|.|.|.| |..:.:|..|...:.:|.....:|:....::....: .:.|.|:
  Fly   195 K----------KEDRGTYYC-VADNGVSKGDRRNINVEVEFAPVITVPRPRLGQALQYDMDLECH 248

Mouse   430 VKGTPLPTVTWTLDDDPILKGSGHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVL 494
            ::..|.|.:.||.||..:.....:.||...|::....|.|.:.:.:.|..|.|.|.|.|..|..
  Fly   249 IEAYPPPAIVWTKDDIQLANNQHYSISHFATADEYTDSTLRVITVEKRQYGDYVCKATNRFGEA- 312

Mouse   495 YQARINV 501
             :||:|:
  Fly   313 -EARVNL 318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam	XP_006522949.1	Ig	15..115	CDD:386229
		IGc2	239..300	CDD:197706	14/60 (23%)
		IG	320..400	CDD:214652	11/79 (14%)
		Ig_3	410..488	CDD:372822	19/78 (24%)
		IGc2	518..575	CDD:197706
		Ig	596..686	CDD:386229
		Ig_DSCAM	707..784	CDD:143211
		Ig	802..889	CDD:386229
		FN3	885..978	CDD:238020
		FN3	986..1083	CDD:238020
		FN3	1091..1184	CDD:238020
		FN3	1189..1278	CDD:238020
		Ig_3	1301..1363	CDD:372822
		FN3	1380..1470	CDD:238020
		FN3	1486..1555	CDD:238020
Lac	NP_523713.2	IG_like	36..131	CDD:214653	25/94 (27%)
		FR1	37..50	CDD:409353	2/12 (17%)
		Ig strand A'	37..42	CDD:409353	0/4 (0%)
		Ig strand B	44..51	CDD:409353	1/6 (17%)
		CDR1	51..59	CDD:409353	1/7 (14%)
		Ig strand C	59..63	CDD:409353	1/3 (33%)
		FR2	60..63	CDD:409353	1/2 (50%)
		CDR2	67..81	CDD:409353	5/13 (38%)
		Ig strand C'	68..72	CDD:409353	2/3 (67%)
		Ig strand C'	79..81	CDD:409353	0/1 (0%)
		FR3	84..115	CDD:409353	10/30 (33%)
		Ig strand D	84..90	CDD:409353	0/5 (0%)
		Ig strand E	94..102	CDD:409353	4/7 (57%)
		Ig strand F	108..115	CDD:409353	2/6 (33%)
		CDR3	116..124	CDD:409353	2/7 (29%)
		FR4	124..130	CDD:409353	1/5 (20%)
		Ig strand G	124..130	CDD:409353	1/5 (20%)
		Ig_3	134..208	CDD:404760	29/175 (17%)
		Ig strand B	153..157	CDD:409353	1/3 (33%)
		Ig strand C	166..170	CDD:409353	0/3 (0%)
		Ig strand E	187..191	CDD:409353	0/3 (0%)
		Ig strand F	201..206	CDD:409353	2/5 (40%)
		Ig strand G	215..218	CDD:409353	0/2 (0%)
		Ig	227..318	CDD:416386	23/92 (25%)
		Ig strand C	256..260	CDD:409353	0/3 (0%)
		Ig strand E	286..290	CDD:409353	2/3 (67%)
		Ig strand F	300..305	CDD:409353	2/4 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810