DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam and DIP-theta

DIOPT Version :9

Sequence 1:XP_006522949.1 Gene:Dscam / 13508 MGIID:1196281 Length:2034 Species:Mus musculus
Sequence 2:NP_723103.1 Gene:DIP-theta / 33795 FlyBaseID:FBgn0051646 Length:606 Species:Drosophila melanogaster


Alignment Length:634 Identity:146/634 - (23%)
Similarity:216/634 - (34%) Gaps:161/634 - (25%)


- Green bases have known domain annotations that are detailed below.


Mouse   421 AEPVSLVCNVKGTPLPTVTWTLDDDPILKGSGHRISQMITSEGNVVSYLNISSSQVRDGGVYRCT 485
            |..||::|  ....||.......||   :|..|.:.||.....:.:    |..|:..|...:...
  Fly    48 AAVVSIIC--LSLALPGCAAQESDD---EGELHHLDQMHHQHQDFI----IGESEEHDHIAHHLA 103

Mouse   486 ANNSAGVVLYQAR----INVRGPASIRP-----MKNITAIAGRDTYIHCRVIGYPYYSIKWYK-- 539
            ...:...:|...|    :|.. |....|     ::|:|....|:..:.|.|.....|.|.|.:  
  Fly   104 EMQNKDELLEDIREDTVVNAI-PEKDLPKFGELLQNVTVPVSREAVLQCVVDNLQTYKIAWLRVD 167

Mouse   540 -------NANLLPFNHRQV---AFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVK 594
                   ..:::..|||..   |.:....|::.|| ||.|:|.|.|.:...|.  .||..::.|.
  Fly   168 TQTILTIQNHVITKNHRMSITHAEKRAWILRIRDV-KESDKGWYMCQINTDPM--KSQVGYLDVV 229

Mouse   595 VPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPASLGVTIDNIDFTSSLRISNL 659
            |||                                                |.:|:.:|      
  Fly   230 VPP------------------------------------------------DILDYPTS------ 240

Mouse   660 SLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWK 724
                                  :.:::|               .|..|.|.|:|.|.|.|||.|:
  Fly   241 ----------------------TDMVIR---------------EGSNVTLKCAATGSPTPTITWR 268

Mouse   725 FSKGAGVPQFQPIALNGRIQVLSNGSLL-IKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPA 788
            ...|..:|     ..||...|..|||.| |..|...:.|.|||..||.:...|||.:.|.|..|.
  Fly   269 REGGELIP-----LPNGAEAVAYNGSFLTIAKVNRLNMGAYLCIASNGIPPTVSKRVMLIVHFPP 328

Mouse   789 MITSYPNTTLATQGQRKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQIL 853
            ||........|...|...:.|.:......|..|.|.|.||.|. .|::..|.|.|.::...|.|.
  Fly   329 MIWIQNQLVGAALTQNITLECQSEAYPKSINYWMKNDTIIVPG-ERFVPETFESGYKITMRLTIY 392

Mouse   854 PTVREDSGFFSCHAINSYGEDRGIIQL-----TVQEPPDPPEIEIKDVKARTITLRWT----MGF 909
            ....:|.|.:.|.|.||.|:..|.|:|     |.......|.:.|..|.  .:.:::.    .|.
  Fly   393 EVDIQDFGAYRCVAKNSLGDTDGAIKLYHIPQTTTMTTMAPTVSINTVP--VVLVKYNKEQRYGS 455

Mouse   910 DGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSE---P 971
            ..||....|:....|      |.|.||....:.||.. .|..||...::.:.|.:.:..|:   .
  Fly   456 SQNSNTNPYNFNPGN------SQQNTKLQRGKSNSKG-SDQSPSGLNNVFVGATSSLWNSQDHHS 513

Mouse   972 SNEITITADEAAPDGPPQEVHLEPTSSQ------SIRVTWKAPKKHLQN 1014
            |:..:.:|.....|...|:.|.:...:.      |.|...|:|  ||.|
  Fly   514 SSSSSSSASSRGRDHHQQQHHQQQQQNHGSDHGASYRSDGKSP--HLTN 560

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DscamXP_006522949.1 Ig 15..115 CDD:386229
IGc2 239..300 CDD:197706
IG 320..400 CDD:214652
Ig_3 410..488 CDD:372822 15/66 (23%)
IGc2 518..575 CDD:197706 18/68 (26%)
Ig 596..686 CDD:386229 5/89 (6%)
Ig_DSCAM 707..784 CDD:143211 31/77 (40%)
Ig 802..889 CDD:386229 26/91 (29%)
FN3 885..978 CDD:238020 20/99 (20%)
FN3 986..1083 CDD:238020 9/35 (26%)
FN3 1091..1184 CDD:238020
FN3 1189..1278 CDD:238020
Ig_3 1301..1363 CDD:372822
FN3 1380..1470 CDD:238020
FN3 1486..1555 CDD:238020
DIP-thetaNP_723103.1 Ig 137..230 CDD:299845 25/95 (26%)
IG_like 137..230 CDD:214653 25/95 (26%)
IG_like 240..324 CDD:214653 34/131 (26%)
IGc2 247..310 CDD:197706 26/67 (39%)
Ig 327..419 CDD:299845 28/92 (30%)
IG_like 343..420 CDD:214653 24/77 (31%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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