DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam and bdl

DIOPT Version :9

Sequence 1:	XP_006522949.1	Gene:	Dscam / 13508	MGIID:	1196281	Length:	2034	Species:	Mus musculus
Sequence 2:	NP_608822.1	Gene:	bdl / 33635	FlyBaseID:	FBgn0028482	Length:	719	Species:	Drosophila melanogaster

Alignment Length:	726	Identity:	167/726 - (23%)
Similarity:	261/726 - (35%)	Gaps:	214/726 - (29%)

- Green bases have known domain annotations that are detailed below.

Mouse   434 PLP-TVTWTLDDDPILKGSGHR--ISQMITSEGNVV--------SYLNISSSQVRDGGVYRCTA- 486
            |:| .|.||.|:..|.......  .|::.....::|        :.:|:::.:..|.|.|.|..
  Fly    64 PIPYLVHWTKDNKKIFTWYEQETSTSELFNGRLHLVENHPEFGRASVNLTAIRESDQGWYHCQVS 128

Mouse   487 --NNSAGV----VLYQARINVRGPASIR-PMKNITAIAGRDTYIHCRVIGYPYYS-IKWYKNANL 543
              |.|..|    ..|  .:.|:|.:.|| |..|.|...|:..:.|| |:.:|..| ..|||:..|
  Fly   129 FPNRSPSVRNNGTAY--HLAVQGGSLIRIPPVNQTIREGQTAFFHC-VMKHPENSQASWYKDGVL 190

Mouse   544 LPFNH---RQVAFENNGTLKLSDVQKEVDEGEYTCNVL-VQPQLSTSQ---SVHVTVKV----PP 597
            |....   |:.....:|:|.: |.....|.|||.|.|. ...:|.|::   ::....||    |.
  Fly   191 LQEVQDLVRRFYMGPDGSLSI-DPTMMSDLGEYECKVRNSDGELQTAKAFLNIQYKAKVIYAPPE 254

Mouse   598 FIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPASLGVTIDNID-------FTSSLR 655
            ...|:       ||...:.|...:......:.|:||        |:..|:.:       ...||.
  Fly   255 VFLPY-------GQPAVLDCHFRANPPLKNLRWEKD--------GLLFDSYNVPGVFYKMNGSLF 304

Mouse   656 ISNLSLMHNGNYTCIARNEAAAVEHQS---QLIVRVPPKFVVQPRDQDGIY----GKAVILNCSA 713
            .:.:...|.|:|||...|: ...:..|   .:||..||.|.|.|:   .||    |:|..|.|.|
  Fly   305 FAKVDENHAGSYTCTPYND-LGTDGPSPVISVIVLRPPIFSVTPK---AIYIQKLGEAAELPCEA 365

Mouse   714 ---EGYPVPTIVWKFSKGAGVP--QFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVG 773
               :|...|:|:|....|..:|  :|.          ||.|:|.|..:||.|.|.|.|..:|:.
  Fly   366 IDRDGNNRPSIIWGRKDGQPLPADRFS----------LSGGNLTITGLVEGDRGIYECSATNEA- 419

Mouse   774 ADVSKSMYLTVKIPAMITSYPNTTLATQGQRKEMSCTAHG-EKPIIVRWEKEDRIINPEMARYLV 837
                          |.||:.....:.....|...:.||:. |..|.:||  :...:.|.: .|.|
  Fly   420 --------------ATITAEAELMIENIAPRAPYNLTANSTETCITIRW--QPGYLRPNL-EYTV 467

Mouse   838 STKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPPEIEI--------- 893
            ..:.:......||::|                    |:.:::.|||......|.|.
  Fly   468 WYRLMEAPEWRTLRVL--------------------DKKVMEATVQHLQPGKEYEFMVLSQDKYG 512

Mouse   894 -----KDVKARTITLRWTMGFDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPS 953
                 |..:.:|:.          |||         ::|.:|:.|...|    |...|.    |:
  Fly   513 DGMFSKQFRFQTLP----------SPI---------RADDFDAQQLQHD----LGQVTA----PA 550

Mouse   954 STYSIRMYAKNRIGKSEPSNEITITADEA---APDGPPQEVHLEPTSSQSIRVTWKAPKKHLQNG 1015
            .            |...|.|...|:..:.   ..:.|.|  .||.....::| .||.|:..|
  Fly   551 G------------GLGAPWNLTAISNQQGWLLHWEHPVQ--GLEGLRLYAVR-WWKEPEHFL--- 597

Mouse  1016 IIRGYQIGYREYSTGGNFQFNIISIDTTGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEII 1080
                  ||:.|  |..|:               |.|.:|.:.|.:.:.|.|     .|..:|:.:
  Fly   598 ------IGHAE--TFDNY---------------YQLRHLKEDTLFKVQVLA-----VGTETQQSV 634

Mouse  1081 TT--TLEDVPS 1089
            .:  .|.||||
  Fly   635 PSHELLIDVPS 645

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam	XP_006522949.1	Ig	15..115	CDD:386229
		IGc2	239..300	CDD:197706
		IG	320..400	CDD:214652
		Ig_3	410..488	CDD:372822	14/67 (21%)
		IGc2	518..575	CDD:197706	19/60 (32%)
		Ig	596..686	CDD:386229	19/99 (19%)
		Ig_DSCAM	707..784	CDD:143211	22/81 (27%)
		Ig	802..889	CDD:386229	17/87 (20%)
		FN3	885..978	CDD:238020	17/106 (16%)
		FN3	986..1083	CDD:238020	22/98 (22%)
		FN3	1091..1184	CDD:238020
		FN3	1189..1278	CDD:238020
		Ig_3	1301..1363	CDD:372822
		FN3	1380..1470	CDD:238020
		FN3	1486..1555	CDD:238020
bdl	NP_608822.1	IG_like	42..128	CDD:214653	14/63 (22%)
		Ig	43..131	CDD:299845	14/66 (21%)
		I-set	153..242	CDD:254352	28/90 (31%)
		Ig	157..242	CDD:299845	25/86 (29%)
		Ig_2	252..337	CDD:290606	19/100 (19%)
		IG_like	260..327	CDD:214653	16/75 (21%)
		I-set	341..428	CDD:254352	33/114 (29%)
		IGc2	356..419	CDD:197706	24/72 (33%)
		FN3	435..524	CDD:238020	20/111 (18%)
		FN3	554..636	CDD:238020	25/115 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10075
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910