DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam and rst

DIOPT Version :9

Sequence 1:	XP_006522949.1	Gene:	Dscam / 13508	MGIID:	1196281	Length:	2034	Species:	Mus musculus
Sequence 2:	NP_001284835.1	Gene:	rst / 31290	FlyBaseID:	FBgn0003285	Length:	764	Species:	Drosophila melanogaster

Alignment Length:	822	Identity:	183/822 - (22%)
Similarity:	291/822 - (35%)	Gaps:	183/822 - (22%)

- Green bases have known domain annotations that are detailed below.

Mouse     7 SLFQSFANV-FSEEPHSSLYFVNASLQEVVFASTSGTLVPCPAAGIPPVTLRWY-----LATGEE 65
            |.:.|:.|. |:.||......|.|.:           .:||.... ...||:|.     |.|..
  Fly    20 SPYTSYQNQRFAMEPQDQTAVVGARV-----------TLPCRVIN-KQGTLQWTKDDFGLGTSR- 71

Mouse    66 IYDVPGIRHVHPNG-------TLQIFPFPPSSFSTLIHDNTYYC-TAENPSGK--IRSQDVHIKA 120
              |:.|.......|       :|.|:|.      .|..|..|.| .:..|.|:  |||....: .
  Fly    72 --DLSGFERYAMVGSDEEGDYSLDIYPV------MLDDDARYQCQVSPGPEGQPAIRSTFAGL-T 127

Mouse   121 VLREPYTVRV---------EDQKTMRGNVAVFKCIIPSSVEAYVTVVSW------------EKDT 164
            ||..|...::         ||:|      ...:|:......|  ..::|            |...
  Fly   128 VLVPPEAPKITQGDVIYATEDRK------VEIECVSVGGKPA--AEITWIDGLGNVLTDNIEYTV 184

Mouse   165 VSLVSGSRFLITSTGALYIKDVQNEDGLYNYRCITRHRYTGETRQSNSARLFV------------ 217
            :.|....||...|...|..|   .|....|:.|..::  |.: |...||::.|
  Fly   185 IPLPDQRRFTAKSVLRLTPK---KEHHNTNFSCQAQN--TAD-RTYRSAKIRVEVKYAPKVKVNV 243

Mouse   218 --SDPANSAPSI---LDGFDH----RKAMAGQRVELPCKALGHP-EPDYRWLKDNMPLELSGRFQ 272
              |.|..:..|:   ..|..|    .:.:...:|.|.|:|..:| :..|||..::.|: :.|  |
  Fly   244 MGSLPGGAGGSVGGAGGGSVHMSTGSRIVEHSQVRLECRADANPSDVRYRWFINDEPI-IGG--Q 305

Mouse   273 KTVTGLLIEN-SRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLSCS 336
            |  |.::|.| :|........|||.|..|.::....|.:.........|:.:::.|||.|||:|.
  Fly   306 K--TEMVIRNVTRKFHDAIVKCEVQNSVGKSEDSETLDISYAPSFRQRPQSMEADVGSVVSLTCE 368

Mouse   337 VTGNEDQELSWYRNGEILNPGKNVRITGLNHANLIMDHMVKSD-GGAYQCFVRKD---KLSAQDY 397
            |..|...|:.|     |.:|...|..|..|     :...|.:: .|.|.|.....   ::||..|
  Fly   369 VDSNPQPEIVW-----IQHPSDRVVGTSTN-----LTFSVSNETAGRYYCKANVPGYAEISADAY 423

Mouse   398 VQVVLEDGTPKIISAFSEKVVSPAEPVSLVCNVKGTPLPT-VTWTLDDDPILKGSGHRISQMITS 461
            |.:   .|:|.|.|..::..: ..:...:.|.....|... |:||.:...|...|||..|.::.:
  Fly   424 VYL---KGSPAIGSQRTQYGL-VGDTARIECFASSVPRARHVSWTFNGQEISSESGHDYSILVDA 484

Mouse   462 -EGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIRPMKNITAIAGRD----- 520
             .|.|.|.|.|..||....|.|.||..|..|..:.:.::..:...|:.    :|.:.|..
  Fly   485 VPGGVKSTLIIRDSQAYHYGKYNCTVVNDYGNDVAEIQLQAKKSVSLL----MTIVGGISVVAFL 545

Mouse   521 --------TYIHCRVIGYPYYSIKWYKNANLLP---FNHRQVAFENNG----------TLKLSDV 564
                    .||.|:            |...|.|   .:..|:. :|.|          |...||:
  Fly   546 LVLTILVVVYIKCK------------KRTKLPPADVISEHQIT-KNGGVSCKLEPGDRTSNYSDL 597

Mouse   565 QKE-----VDEGEYTCNVLVQPQ----LSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVV 620
            :.:     |..|:|:.:....||    .||..:...|:.........:..:..  |:........
  Fly   598 KVDISGGYVPYGDYSTHYSPPPQYLTTCSTKSNGSSTIMQNNHQNQLQLQQQQ--QQSHHQHHTQ 660

Mouse   621 SGDLPITITWQKDGRPIPASL----GVTIDN-IDFTSSLRISNLSLMHNGNYTCIARNEAAAVEH 680
            :..||:|......|..:..|:    .:..|| :....|...|.:|...||  :|..::..||...
  Fly   661 TTTLPMTFLTNSSGGSLTGSIIGSREIRQDNGLPSLQSTTASVVSSSPNG--SCSNQSTTAATTT 723

Mouse   681 QSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIV 722
            .:.::|.......|.|| ...|||...:.:.::...|.||.|
  Fly   724 TTHVVVPSSMALSVDPR-YSAIYGNPYLRSSNSSLLPPPTAV 764

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam	XP_006522949.1	Ig	15..115	CDD:386229	27/115 (23%)
		IGc2	239..300	CDD:197706	20/62 (32%)
		IG	320..400	CDD:214652	25/83 (30%)
		Ig_3	410..488	CDD:372822	22/79 (28%)
		IGc2	518..575	CDD:197706	16/87 (18%)
		Ig	596..686	CDD:386229	16/94 (17%)
		Ig_DSCAM	707..784	CDD:143211	4/16 (25%)
		Ig	802..889	CDD:386229
		FN3	885..978	CDD:238020
		FN3	986..1083	CDD:238020
		FN3	1091..1184	CDD:238020
		FN3	1189..1278	CDD:238020
		Ig_3	1301..1363	CDD:372822
		FN3	1380..1470	CDD:238020
		FN3	1486..1555	CDD:238020
rst	NP_001284835.1	IG_like	34..130	CDD:214653	26/117 (22%)
		Ig	42..114	CDD:299845	18/92 (20%)
		C2-set_2	135..225	CDD:285423	18/103 (17%)
		Ig_3	265..329	CDD:290638	19/68 (28%)
		I-set	346..420	CDD:254352	21/83 (25%)
		Ig	360..425	CDD:299845	22/74 (30%)
		Ig5_KIRREL3-like	428..524	CDD:143235	27/96 (28%)
		IG_like	435..524	CDD:214653	23/89 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900