DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam and Dscam4

DIOPT Version :9

Sequence 1:	XP_006522949.1	Gene:	Dscam / 13508	MGIID:	1196281	Length:	2034	Species:	Mus musculus
Sequence 2:	NP_001261571.1	Gene:	Dscam4 / 2769008	FlyBaseID:	FBgn0263219	Length:	1935	Species:	Drosophila melanogaster

Alignment Length:	1966	Identity:	613/1966 - (31%)
Similarity:	953/1966 - (48%)	Gaps:	197/1966 - (10%)

- Green bases have known domain annotations that are detailed below.

Mouse     7 SLFQSFANVFSEEPHSSLYFVNASLQ----------EVVFASTSGTLVPCPAAGIPPVTLRWYLA 61
            |||::...::.....:|.:.....||          .|.|::.||.|:.|...|.||..:.|...
  Fly     5 SLFKAILILYVIRAETSQFVNGLDLQGPIFLHEPPHRVEFSNNSGGLIECSGHGSPPPEVEWTPI 69

Mouse    62 TGEE--IYDVPGIRHVHPNGTLQIFPFPPSSFSTLIHDNTYYCTAENPSGKIRSQDVHIKAVLRE 124
            ..::  ::.:       .||::..:||....:...:|...|.|...|..|.:.|::||::.|:.:
  Fly    70 PPQQDMVFQL-------SNGSMMFYPFTAEKYRHEVHATVYRCKLRNLVGTVLSREVHVRGVVNQ 127

Mouse   125 PYTVRVEDQKTMRGNVAVFKCIIPSSVEAYVTVVSWEKDT-----VSLVSGSRFLITSTGALYIK 184
            .|.|:|.|:..|.||.||.||.:||.:..:|.|.:|.:||     .:...|.::.:.|.|.|||.
  Fly   128 KYAVQVHDEYVMTGNTAVLKCQVPSYMSEFVLVTAWVQDTGMHLYPNTDIGGKYTVLSNGELYIN 192

Mouse   185 DVQNEDGLYNYRCITRHRYTGETRQSN-SARLFVSDPANSAPSILDGFDH--RKAMAGQRVELPC 246
            :....|...:|.|.|.:|.|||.:.|. ..|:.|::|.......::...|  |..:...:..|||
  Fly   193 NAGPNDAYKSYTCRTVNRLTGEVQISTYPGRIIVTEPKGMVQPRINVEKHSMRHVVLNGQTTLPC 257

Mouse   247 KALGHPEPDYRWLKDN----MPLELSGRFQKTVTGLL-IENSRPSDSGSYVCEVSNRYGTAKVIG 306
            .|.|||.|.|||.|:.    :||:||.|......||| |..:|..|||.|:|.|:|..|...:..
  Fly   258 IAQGHPVPTYRWFKEENEQLLPLQLSERITIVSAGLLKITKARLEDSGKYLCWVNNTAGEETIQV 322

Mouse   307 RLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGNEDQELSWYRNGEILNPGKNVRITGLNHANLI 371
            .|.|..||.|.:.|:.....|.......|.|:|:...:::|..:|:.:.....|.|. .:...||
  Fly   323 SLTVTAPLTAHLQPQVQTVDVDKDAQFQCIVSGHPVHDVNWLHDGKPILRDNRVEIL-TDPPRLI 386

Mouse   372 MDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLVCNVKGTPLP 436
            :..:.|.|.|.|||||..:....|...::.|.|.:|:::..|||:.:.|...|||.|...|.|||
  Fly   387 IKKVQKEDPGMYQCFVSNEWEQIQSTAELQLGDASPELLYWFSEQTLQPGPTVSLKCVATGNPLP 451

Mouse   437 TVTWTLDDDPILKGSGHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINV 501
            ..||:||..||...|...:.|.:|...:|:|::|||:.:..|||.|.|||.|:.|.|.:.|::|:
  Fly   452 QFTWSLDGFPIPDSSRFLVGQYVTIHDDVISHVNISNVKEEDGGEYTCTAQNAIGKVSHSAKVNI 516

Mouse   502 RGPASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNANLLPFNHRQVAFENNGTLKLSDVQK 566
            .|...||.|..||.|:|.|..:.|.|.|||...|.|.::...||.|.||.|: |||||.:..:|:
  Fly   517 YGLPYIREMPKITGISGSDLIVKCPVAGYPIDKIHWERDGQTLPINRRQRAY-NNGTLIIEQLQR 580

Mouse   567 EVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSI--GQRVFIPCVVVSGDLPITIT 629
            ..|.|.|||....:.:.::.::|.:.|.|||.|.|.:.....:  |.|..|.|.::.||||::..
  Fly   581 LEDAGTYTCMAQNKQKQTSRRNVEIQVLVPPKIMPIQAMTNMLREGMRAAISCQILEGDLPVSFR 645

Mouse   630 WQKDGRPIPASLGVTIDNID-FTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFV 693
            |:::|:|:..:.......:| :::||.|.::|..|:|||||||.|.|........|.|.||||::
  Fly   646 WERNGKPLIGTGNEVFRRLDEYSASLVIEHISSDHSGNYTCIASNVAGTERFTVPLTVNVPPKWI 710

Mouse   694 VQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVE 758
            ::|:|.....|..|:|:|.:.|||.|||.||.:.|....:::.......:|:..||::..|.:.:
  Fly   711 LEPKDSSAQAGADVLLHCQSSGYPTPTITWKKAIGPTPGEYKDFLYEPTVQLFPNGTIFFKKISK 775

Mouse   759 EDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQRKEMSCTAHGEKPIIVRW-- 821
            |..|::||:..|::|:.|||.::|.|.:||...:........:|::..:.|...|:.||..:|
  Fly   776 ESQGHFLCEAKNNIGSGVSKVIFLKVNVPAHFQTKTKQISVAKGKQVHVQCNVQGDNPIDFKWKI 840

Mouse   822 EKEDRIINPEM-ARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEP 885
            :...:.::..: :||.:..:.:.:.::|.|.|..|.|:|:|.:.|.|.|::|:|...|||.|||.
  Fly   841 QATQQYLDESLDSRYTIRDQVLDDGMVSELGISHTYRQDTGIYICQASNAFGQDEMSIQLIVQEV 905

Mouse   886 PDPPE-IEIKDVKARTITLRWTMGFDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIID 949
            |:.|: :.|...::|::.|.|:..|.|||||..|.|..|..||.|.:|:.......|    |:|:
  Fly   906 PEQPKNLRINSQQSRSLQLTWSQPFAGNSPIEEYHIYYKQISDIWQNAEHLTIAGAQ----TVIN 966

Mouse   950 I---HPSSTYSIRMYAKNRIGKSEPSNEITITADEAAPDGPPQEVHLEPTSSQSIRVTWKAPKKH 1011
            |   .|:..|.|||.|:|::|.||.|..:.:|..|..|.|||..|..||.||..|.|||.||::.
  Fly   967 IQQLRPAKAYHIRMSAENKLGASEFSEVVQVTTLEEVPSGPPLAVRAEPKSSTEIFVTWDAPERD 1031

Mouse  1012 LQNGIIRGYQIGY--------REYSTGGNFQFNIISIDTTGDSEVYTLDNLNKFTQYGLVVQACN 1068
            ..|||:.||.:||        :|.:....|.|..:.:.:....|. .|.||||||||.::|||..
  Fly  1032 HWNGILLGYYVGYQMSLTPEDKEVNPTQGFSFKTVEVRSHFGGET-VLANLNKFTQYHVIVQAYT 1095

Mouse  1069 RAGTGPSSQEIITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLI 1133
            ..|:||.|:||...|:|||||.|||:.|.......||.|:||....:..||.::|::|.|.:  :
  Fly  1096 SQGSGPPSKEIAVQTMEDVPSSPPESPQCDVLGSTSIYITWSPPDIDGQNGKIKGYKVFYIS--V 1158

Mouse  1134 DGELGEI--KNVTTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAGVK 1196
            | ||.|.  :.|.:|...:.::.|.|||||::.|||:|:.|||::::..:.||.||||..|..:|
  Fly  1159 D-ELYETDPEVVKSTNQYVTIENLRKYTNYTVWVLAYTKVGDGMKTKPFYCRTHEDVPSAPQAIK 1222

Mouse  1197 AAAASASMVFVSWLPPLKLNGIIRKYTVFCSHPYPTVISEFEASPDSFSYR-----------IPN 1250
            |..||:|.:.:|||||...||.|..||.:        :|..|...:..:::           ...
  Fly  1223 AIPASSSKIIISWLPPDLPNGDITGYTFY--------MSMLEGGREEGTHKRLLGPFVEMHETVR 1279

Mouse  1251 LSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSP 1315
            ...:..|..|:.|.|..|.|..::::||.|..|.||||::||..:.|||.:.:.|||:.||.|:|
  Fly  1280 TQESATYQFWLTASTKMGEGEKTQVVTVPPNNKVPARIVSFSQRIVTPWKEHLELPCRKVGAPAP 1344

Mouse  1316 AVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCVANNNWGSDEIILNLQVQVPP 1380
            ...|.:|.:.    :....|::|..||:..::..:|.|:|.|:|...|.||.|||:.|:.|:|||
  Fly  1345 VTIWRQDGHN----METSARKTIAKNGTLYMKECQASDAGNYTCSVENTWGKDEIVYNIVVKVPP 1405

Mouse  1381 DQPRLTVSKTTSSSITLSWLPGDNGGSSIRGYILQYSEDNSEQWGSFPISPSERSYRLENLKCGT 1445
            :.|.|||....:.|:.|.|:...:|||.|.||::.|..||.: |....:.....|:.|.||.|||
  Fly  1406 EAPNLTVINAYTDSLLLEWMDNSHGGSPILGYVINYKRDNGD-WEELQVDSKTTSHLLTNLWCGT 1469

Mouse  1446 WYKFTLTAQNGVGPGRISEIIEAKTLGKEPQFSKEQELFASINTTRVRLNLIGWNDGGCPITSFT 1510
            .|:..:||.|.:|.|...:|:.:.|.|..|...|..::..: |:|.|...|..|.||||.|..|.
  Fly  1470 RYQLYITAYNKIGTGLPCDIVNSYTKGNPPVQPKHSQMITN-NSTSVTCWLDSWGDGGCGILYFM 1533

Mouse  1511 LEYRPFGTTVWTTAQR--TSLSKSYILYDLQEATWYELQMRVCNSAGCAEKQANFATLNYDGSTI 1573
            :|.|.:|.:.|.....  ....:.|.:.||...|.|:|::...|:||......||.||:..|...
  Fly  1534 IESRVYGRSSWAVVSNHIPPTERIYTVSDLVPGTKYQLKVTAHNNAGSTTAIYNFTTLSTQGVIY 1598

Mouse  1574 PPLIKSVVQSEEGLTTNEGLKILVTISCILVGVLLLFVLLLVVRRRRREQRLKRLRDAKSLAEML 1638
            .....:.|.....|......|:|:.|...|:.:|.|....|.:|:|       :|.....||...
  Fly  1599 NNDHSTPVSHLSDLPFYANFKLLLPICFSLLMLLALIGAALFLRKR-------KLASQARLASSS 1656

Mouse  1639 MSKNTRTSDTLSKQQQTLRMHIDIPRAQLLIEERDTMETIDDRSTVLLTDADFGEAAKQKSLT-- 1701
            ||::...::..:||.          |.|..:..|....|...|.:.......||:|...:.:.
  Fly  1657 MSESPSLANLQNKQN----------RDQQYLAVRCNPGTSAPRGSNSNDSGSFGKAEGNEYIEDI 1711

Mouse  1702 ---VTHTVHYQSVSQA-------TGPLVDV------SDARPGTNPT-----TRRNAKAGPTARNR 1745
               .|..::.|:.|::       :||...|      .|.:|.:..:     |:...|.|
  Fly  1712 CPYATFQLNKQTYSESSYSGNVYSGPYHSVRGSFVYHDVKPESYHSKEPEYTKVRRKVG------ 1770

Mouse  1746 YASQWTLNRPHPTISAHTLTTDWRLPTPRATGSVDKESDSYSVSPSQDTDRARSSMV-------- 1802
                 .|..||                     |..:|||    :|.......|..:.
  Fly  1771 -----RLRDPH---------------------SESQESD----NPGSTDSEVRKILTLHIPITEY 1805

Mouse  1803 STESASSTYEELARAYEHAKMEEQLRHAKFTITECFISDTSSEQLTAGTNEYTDSLTSSTPSESG 1867
            .|..:.|..:..|||...||...|             .||..|         |.|.:.:||  :.
  Fly  1806 DTLGSESDNDVSARALNSAKYRAQ-------------RDTQDE---------TSSSSETTP--TS 1846

Mouse  1868 ICRFTASPPKPQDGGR 1883
            :.|.:..|...:.||:
  Fly  1847 MTRKSKPPFAARKGGK 1862

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam	XP_006522949.1	Ig	15..115	CDD:386229	23/111 (21%)
		IGc2	239..300	CDD:197706	29/65 (45%)
		IG	320..400	CDD:214652	20/79 (25%)
		Ig_3	410..488	CDD:372822	33/77 (43%)
		IGc2	518..575	CDD:197706	24/56 (43%)
		Ig	596..686	CDD:386229	31/92 (34%)
		Ig_DSCAM	707..784	CDD:143211	26/76 (34%)
		Ig	802..889	CDD:386229	27/89 (30%)
		FN3	885..978	CDD:238020	34/96 (35%)
		FN3	986..1083	CDD:238020	43/104 (41%)
		FN3	1091..1184	CDD:238020	33/94 (35%)
		FN3	1189..1278	CDD:238020	25/99 (25%)
		Ig_3	1301..1363	CDD:372822	18/61 (30%)
		FN3	1380..1470	CDD:238020	32/89 (36%)
		FN3	1486..1555	CDD:238020	22/70 (31%)
Dscam4	NP_001261571.1	Ig	31..124	CDD:416386	22/99 (22%)
		Ig strand A	32..35	CDD:409353	0/2 (0%)
		Ig strand A'	41..45	CDD:409353	1/3 (33%)
		Ig strand B	48..57	CDD:409353	4/8 (50%)
		Ig strand D	75..78	CDD:409353	0/2 (0%)
		Ig strand E	83..88	CDD:409353	0/4 (0%)
		Ig strand F	101..109	CDD:409353	2/7 (29%)
		Ig strand G	112..124	CDD:409353	4/11 (36%)
		Ig	235..326	CDD:416386	33/90 (37%)
		Ig strand A	235..238	CDD:409353	0/2 (0%)
		Ig strand A'	244..248	CDD:409353	1/3 (33%)
		Ig strand B	251..258	CDD:409353	2/6 (33%)
		Ig strand C	266..271	CDD:409353	3/4 (75%)
		Ig strand C'	276..279	CDD:409353	0/2 (0%)
		Ig strand D	285..289	CDD:409353	1/3 (33%)
		Ig strand E	292..298	CDD:409353	4/5 (80%)
		Ig strand F	305..313	CDD:409353	4/7 (57%)
		Ig strand G	316..326	CDD:409353	2/9 (22%)
		IgC2_3_Dscam	329..417	CDD:409549	23/88 (26%)
		Ig strand B	347..351	CDD:409549	0/3 (0%)
		Ig strand C	360..364	CDD:409549	0/3 (0%)
		Ig strand E	383..387	CDD:409549	1/3 (33%)
		Ig strand F	397..402	CDD:409549	3/4 (75%)
		Ig strand G	410..413	CDD:409549	1/2 (50%)
		IgI_4_Dscam	422..516	CDD:409548	38/93 (41%)
		Ig strand B	439..443	CDD:409548	3/3 (100%)
		Ig strand C	452..456	CDD:409548	1/3 (33%)
		Ig strand E	482..486	CDD:409548	1/3 (33%)
		Ig strand F	496..501	CDD:409548	2/4 (50%)
		Ig strand G	509..512	CDD:409548	0/2 (0%)
		IgI_5_Dscam	520..607	CDD:409550	33/87 (38%)
		Ig strand B	536..540	CDD:409550	0/3 (0%)
		Ig strand C	549..553	CDD:409550	1/3 (33%)
		Ig strand E	571..575	CDD:409550	3/3 (100%)
		Ig strand F	586..591	CDD:409550	3/4 (75%)
		Ig strand G	600..603	CDD:409550	0/2 (0%)
		Ig	610..703	CDD:416386	31/92 (34%)
		Ig strand A	611..613	CDD:409353	1/1 (100%)
		Ig strand A'	620..624	CDD:409353	0/3 (0%)
		Ig strand B	627..636	CDD:409353	3/8 (38%)
		Ig strand C	641..648	CDD:409353	2/6 (33%)
		Ig strand C'	650..652	CDD:409353	1/1 (100%)
		Ig strand D	659..664	CDD:409353	0/4 (0%)
		Ig strand E	668..675	CDD:409353	3/6 (50%)
		Ig strand F	682..690	CDD:409353	7/7 (100%)
		Ig strand G	693..702	CDD:409353	0/8 (0%)
		IgI_7_Dscam	706..801	CDD:409546	32/94 (34%)
		Ig strand B	724..728	CDD:409546	2/3 (67%)
		Ig strand C	737..741	CDD:409546	2/3 (67%)
		Ig strand E	766..770	CDD:409546	1/3 (33%)
		Ig strand F	780..785	CDD:409546	2/4 (50%)
		Ig strand G	794..797	CDD:409546	2/2 (100%)
		Ig	818..904	CDD:416386	24/85 (28%)
		putative Ig strand B	820..827	CDD:409353	0/6 (0%)
		putative Ig strand C	835..841	CDD:409353	1/5 (20%)
		putative Ig strand C'	853..856	CDD:409353	1/2 (50%)
		putative Ig strand D	862..866	CDD:409353	0/3 (0%)
		putative Ig strand E	868..874	CDD:409353	3/5 (60%)
		putative Ig strand F	881..889	CDD:409353	3/7 (43%)
		putative Ig strand G	892..902	CDD:409353	5/9 (56%)
		FN3	906..999	CDD:238020	34/96 (35%)
		FN3	1006..1110	CDD:238020	43/104 (41%)
		fn3	1117..1203	CDD:394996	33/88 (38%)
		FN3	1215..1307	CDD:238020	25/99 (25%)
Ig	<1334..1401	CDD:416386	25/70 (36%)
Ig strand C	1345..1349	CDD:409353	0/3 (0%)
Ig strand D	1363..1366	CDD:409353	1/2 (50%)
Ig strand E	1367..1372	CDD:409353	1/4 (25%)
Ig strand F	1380..1388	CDD:409353	3/7 (43%)
Ig strand G	1394..1401	CDD:409353	3/6 (50%)
FN3	1405..1494	CDD:238020	32/89 (36%)
FN3	1499..1580	CDD:238020	24/81 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	136	1.000	Domainoid score	I4889
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H74393
Inparanoid	1	1.050	968	1.000	Inparanoid score	I323
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47134
OrthoDB	1	1.010	-	-		D10185at33208
OrthoFinder	1	1.000	-	-		FOG0003568
OrthoInspector	1	1.000	-	-		mtm8769
orthoMCL	1	0.900	-	-		OOG6_101656
Panther	1	1.100	-	-	O	PTHR10075
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4969
SonicParanoid	1	1.000	-	-		X1391
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.870