DRSC/TRiP Functional Genomics Resources

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Protein Alignment ADORA2A and AdoR

DIOPT Version :9

Sequence 1:NP_000666.2 Gene:ADORA2A / 135 HGNCID:263 Length:412 Species:Homo sapiens
Sequence 2:NP_651772.1 Gene:AdoR / 43583 FlyBaseID:FBgn0039747 Length:774 Species:Drosophila melanogaster


Alignment Length:321 Identity:116/321 - (36%)
Similarity:172/321 - (53%) Gaps:41/321 - (12%)


- Green bases have known domain annotations that are detailed below.


Human     9 YITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAA 73
            |...|:.:|:::|:|||||.........|:..|||::||||.||:.||.|.|||||..|.|....
  Fly    44 YTVFEVLVAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADLLVGALGIPFAILASMGLPRN 108

Human    74 CHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLT 138
            .|.|||....::||...|||.|:|:::|||.||..|:.|:..|....|..||::|||....:|..
  Fly   109 LHACLFTVSLLVVLCTISIFCLVAVSVDRYWAILYPMAYSRNVRTRTAIFIISMCWVAGTIVGFL 173

Human   139 PMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLA 203
            |:.||:      ...||:|       .|||.:|:..||:| |.:||.::.|.||||..|..|:..
  Fly   174 PLFGWH------ADVNHNQ-------ECLFVEVMDYNYLV-FLYFATIITPALLMLAFYTHIYRV 224

Human   204 ARRQLKQMESQPLPGERAR--------------------------STLQKEVHAAKSLAIIVGLF 242
            ..:|::|:.:.....:.:|                          :..:::|.|.::|:|||..|
  Fly   225 IIKQVRQIVTMNPASDLSRRSSAAVVQVTTPGRGGHTGTMLRVLGAARKRDVKATQNLSIIVLFF 289

Human   243 ALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKII 303
            .:||:||:.|||...|||||...|. |....|:|||.||.|||.:|||.:::||...:.::
  Fly   290 MICWIPLYTINCIKAFCPDCYVHPK-LTLFCIILSHLNSAVNPVLYAYHLKDFRAALKNLL 349

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ADORA2ANP_000666.2 7tmA_Adenosine_R_A2A 7..299 CDD:320196 116/315 (37%)
TM helix 1 8..34 CDD:320196 9/24 (38%)
TM helix 2 41..68 CDD:320196 17/26 (65%)
TM helix 3 77..107 CDD:320196 14/29 (48%)
TM helix 4 121..139 CDD:320196 7/17 (41%)
Agonist binding 168..177 3/8 (38%)
TM helix 5 174..204 CDD:320196 13/29 (45%)
TM helix 6 226..256 CDD:320196 14/29 (48%)
Agonist binding 246..253 3/6 (50%)
Agonist binding 264..274 2/9 (22%)
TM helix 7 267..292 CDD:320196 13/24 (54%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 391..412
AdoRNP_651772.1 7tm_4 52..>220 CDD:304433 75/181 (41%)
7tm_1 58..334 CDD:278431 107/290 (37%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165150899
Domainoid 1 1.000 181 1.000 Domainoid score I3483
eggNOG 1 0.900 - - E33208_3BF5B
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000536
OrthoInspector 1 1.000 - - otm40873
orthoMCL 1 0.900 - - OOG6_107098
Panther 1 1.100 - - LDO PTHR24246
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X919
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
98.740

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