DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Drp2 and Dys

DIOPT Version :9

Sequence 1:	XP_006528559.1	Gene:	Drp2 / 13497	MGIID:	107432	Length:	981	Species:	Mus musculus
Sequence 2:	NP_001036722.1	Gene:	Dys / 42327	FlyBaseID:	FBgn0260003	Length:	3598	Species:	Drosophila melanogaster

Alignment Length:	896	Identity:	358/896 - (39%)
Similarity:	525/896 - (58%)	Gaps:	109/896 - (12%)

- Green bases have known domain annotations that are detailed below.

Mouse   103 MNLCWNEIKKKSHNLRARLEAFSDLSGKLQLPLREIIDWLSQKDEELS--AQLPLQGDVALVQQE 165
            ||..||.:|.||..:|.|||:.|:....|.|.|||:.:|:.:||.|||  ...|::||...:|::
  Fly  2556 MNQRWNNLKSKSIAIRNRLESNSEHWNALLLSLRELTEWVIRKDTELSTLGLGPVRGDAVSLQKQ 2620

Mouse   166 KETHAAFMEEVKSKGPYISSVLESAQAFLSQHPFEELEESQSESKDT-----------SPRQRIQ 219
            .:.|.||..:::.|.|.:.|.|.|.:.:::.      |.:.|::.||           |..::.:
  Fly  2621 LDDHKAFRRQLEDKRPIVESNLTSGRQYIAN------EAAVSDTSDTEANHDSDSRYMSAEEQSR 2679

Mouse   220 NLSRFVWKQATVASELWEKLTARCVDQHRHIEHTLEHLLEIQGAMEELSSTLTQAEGVRATWEPI 284
            .|:|.:.::....||.|..|..|..:....::..:..:.:.|..:|:|||.:..||..:.:|.|.
  Fly  2680 ELTRSIRREVGKLSEQWNNLIDRSDNWKHRLDEYMTKMRQFQKILEDLSSRVALAEQTKTSWLPP 2744

Mouse   285 GDLFIDSLPEHIQAIKLFKEEFSPVKDGVKLVND--------LAHQLAISDVHLSMENSRALEQI 341
            ..  :....|.:|.::..:::.:...   .|::|        .|:|:.:....||     .||.:
  Fly  2745 SS--VGEANEQMQQLQRLRDKMTTAS---ALLDDCNEQQSFFTANQVLVPTPCLS-----KLEDL 2799

Mouse   342 NIRWKQLQVSVAERLKQL-----QDAHRD------------FGPGSQHFLSTSVQVPWERAISPN 389
            |.|.|.||:::.||.|.|     |..|.:            .||...  |..||:.|||||.:..
  Fly  2800 NTRMKLLQIAMDERQKVLCQAGAQQTHENGDDGRTTSNSGTIGPLPN--LGQSVKPPWERATTAA 2862

Mouse   390 KVPYYINHQAQTTCWDHPKMTELYQTLADLNNIKFSAYRTAMKLRRVQKALRLDLVTLTTALEIF 454
            .|||||:|:.:||.||||:|.||.:.|||||.|:|||||||||||.|||.|.||.::::||.|.|
  Fly  2863 NVPYYIDHERETTHWDHPEMIELMKGLADLNEIRFSAYRTAMKLRSVQKRLALDRISMSTACESF 2927

Mouse   455 NEHDLQA-SEHVMDVVEVIHCLTALYERLEEERGILVNVPLCVDMSLNWLLNVFDSGRSGKMRAL 518
            :.|.|:| ::.::|:.::...|.:||..:::     :::.|.:|:::||:|||:||.|:|::|.|
  Fly  2928 DRHGLRAQNDKLIDIPDMTTVLHSLYVTIDK-----IDLTLMLDLAINWILNVYDSQRTGQIRVL 2987

Mouse   519 SFKTGIACLCGTEVKEKLQYLFSQVANSGSQCDQRHLGALLHEAIQVPRQLGEVAAFGGSNVEPS 583
            |||.|:..||...::||.:|||..||::..:.|||.||.|||:.|||||||||||||||||:|||
  Fly  2988 SFKVGLVLLCKGHLEEKYRYLFRLVADTDRRADQRRLGLLLHDCIQVPRQLGEVAAFGGSNIEPS 3052

Mouse   584 VRSCF-RFSTGKPVIEASQ--------FLEWVNLEPQSMVWLAVLHRVTIAEQVKHQTKCSICRQ 639
            ||||. :....:..|:.:|        ||.|:..||||:|||.||||:..||..|||.||:||::
  Fly  3053 VRSCLEQAGISQEAIDGNQDISIELQHFLGWLQHEPQSLVWLPVLHRLAAAEAAKHQAKCNICKE 3117

Mouse   640 CPIKGFRYRSLKQFNVDICQTCFLTGRASKGNKLHYPIMEYYTPTTSSENMRDFATTLKNKFRSK 704
            .||.|||||.||.||.|:||.||..||.:|.:||.:|:.||.|.|||:|::|||...|||||:|:
  Fly  3118 YPIVGFRYRCLKCFNFDMCQKCFFFGRNAKNHKLTHPMHEYCTTTTSTEDVRDFTRALKNKFKSR 3182

Mouse   705 QYFSKHPQRGYLPVQSVLESDCSETPASSPMLPHA------DTHSRIEHFASRLAEMESQNCSFF 763
            :||.|||:.||||||||||.|..|:||.||.  |.      |.|||:|.:|||||::|...
  Fly  3183 KYFKKHPRVGYLPVQSVLEGDALESPAPSPQ--HTTHQLQNDMHSRLEMYASRLAQVEYGG---- 3241

Mouse   764 NDSLSPDDSIDEDQYLLRHSSPITDREPAFGQQAP----CSMATESKGELEKILAHLEDENRILQ 824
            ..|.|..||.||.|.:.::...:.........::|    .:|..|.:.|||.|:..||:||..||
  Fly  3242 TGSNSTPDSDDEHQLIAQYCQALPGTSNGSAPKSPVQVMAAMDAEQREELEAIIRDLEEENANLQ 3306

Mouse   825 GELRRL--KWQH---------EEAAEAPTLVEGSAEATPDHRNEELLAEARILRQHKSRLETRMQ 878
            .|.::|  |.|.         :.::.:.|.:.|..|     :.::::|||::|||||.|||.|||
  Fly  3307 AEYQQLCSKEQSGMPEDSNGMQHSSSSMTGLSGQGE-----QGQDMMAEAKLLRQHKGRLEARMQ 3366

Mouse   879 ILEDHNKQLESQLQRLRELLLQPPSESDGNGSAGSS--LASSPRQSEGSHP 927
            ||||||:|||:||||||:||.:|    :|.||:.:|  |.|:|..:..|.|
  Fly  3367 ILEDHNRQLEAQLQRLRQLLDEP----NGGGSSATSSGLPSAPGSALNSKP 3413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Drp2	XP_006528559.1	SPEC	135..363	CDD:238103	62/253 (25%)
		WW	381..409	CDD:238122	17/27 (63%)
		EFh_DRP-2	446..607	CDD:320006	74/170 (44%)
		EF-hand-like motif	446..484	CDD:320006	11/38 (29%)
		EF-hand-like motif	492..526	CDD:320006	17/33 (52%)
		EF-hand-like motif	532..568	CDD:320006	19/35 (54%)
		EF-hand-like motif	581..607	CDD:320006	12/34 (35%)
		ZZ_dystrophin	632..680	CDD:239074	26/47 (55%)
		SMC_prok_A	<740..906	CDD:274009	70/180 (39%)
Dys	NP_001036722.1	CH	13..111	CDD:278723
		CH	129..225	CDD:278723
		SPEC	312..525	CDD:238103
		SbcC	<325..957	CDD:223496
		Smc	<816..1591	CDD:224117
		SPEC	1174..1365	CDD:238103
		SPEC	1289..1485	CDD:295325
		SPEC	2369..2576	CDD:238103	10/19 (53%)
		SPEC	2477..2714	CDD:238103	47/163 (29%)
		WW	2852..2882	CDD:238122	17/29 (59%)
		EF-hand_2	2883..2997	CDD:286194	53/118 (45%)
		EF-hand_3	3001..3100	CDD:286195	54/98 (55%)
		ZZ_dystrophin	3110..3158	CDD:239074	26/47 (55%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	124	1.000	Domainoid score	I5490
eggNOG	1	0.900	-	-		E2759_KOG4286
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D46278at33208
OrthoFinder	1	1.000	-	-		FOG0001792
OrthoInspector	1	1.000	-	-		otm44112
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4540
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.850