DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Slc26a3 and CG5404

DIOPT Version :9

Sequence 1:	NP_067328.1	Gene:	Slc26a3 / 13487	MGIID:	107181	Length:	757	Species:	Mus musculus
Sequence 2:	NP_650482.1	Gene:	CG5404 / 41901	FlyBaseID:	FBgn0038354	Length:	627	Species:	Drosophila melanogaster

Alignment Length:	702	Identity:	164/702 - (23%)
Similarity:	289/702 - (41%)	Gaps:	164/702 - (23%)

- Green bases have known domain annotations that are detailed below.

Mouse    26 KKTHRHHKTFLDHLKGCCSCSSQKAKKIALSLFPIASWLPAYKIKEWLLSDIVSGISTGLVAVLQ 90
            ::.|||                          .|:..|||.|. .||.:.|.::||:.||..:.:
  Fly    43 RRLHRH--------------------------VPVFQWLPLYS-TEWGIDDFIAGITLGLTIIPE 80

Mouse    91 GLAFALLVNIPPAYGLYAAFFPVITYFFLGTSRHISVGPFPVLSMMVGVVVTRVVSDPNASSELS 155
            .:|.|||..:|..|||.:||...:.|...|:...:.:||   .|::..|.|...|..|
  Fly    81 SMACALLAGLPARYGLCSAFIGPLIYMVFGSIDKVIIGP---TSLVALVSVQFTVGRP------- 135

Mouse   156 SSSTENDSFIEEKVMVAASVTVLSGIIQLLLGVLQVGFVVIYLSESLISGFTTAAAIHVLVSQLK 220
                         :..|..:|.||||:|:::|.:::||:..::|..:|..|::|.||.|:.||||
  Fly   136 -------------IEFAFLLTFLSGIVQIIMGTMRMGFIFEFISMPVIKAFSSATAILVIESQLK 187

Mouse   221 FMLQLPVPAYSDPFSIFKVLESV---FTQIQKTNIADLVTSVIILVVVFVFKEI----NQRYRSK 278
            .:|.:       .:.:..::.||   .::|:::|:|||:..|..:|.:.:.:.:    |...|:|
  Fly   188 VLLGI-------KYLVAGLMNSVGMLSSRIEESNMADLIMGVCAIVFLLLLELLDRVANNEKRNK 245

Mouse   279 L------PVPIPIELIMTVIATGVSY----GCNFEDRFGVAVVGNMSLGFQPPIT-PSV------ 326
            :      .:......::.:||..||:    .|.   :...|:..| :|...|..| ||.
  Fly   246 ILRIFCRYLSTSRNTLIVLIAAIVSFIWIQKCG---QVPYALSKN-ALSTLPNFTVPSFHIETAE 306

Mouse   327 ------EVFQDTIGDSFGIAIVGFAVAFSVASVYSLKYDYPIDGNQELIALGVSNIFTGAFKGFA 385
                  ||.::.   :.||.::......:..|:..|.....:|.||||:.:|:.|:|....:...
  Fly   307 RNYSIWEVLKEL---NIGIIVIPIVGILTNISIGKLTPKGLVDTNQELLTVGLCNMFGSCVQAMP 368

Mouse   386 GSTALSRSGVQESTGGKTQVAGLLSAVIVLIVIVAIGFLLQPLQKSVLAALALGNLKGMLMQFAE 450
            .|.|.:|..:..:.|.:|.:|.|...:|||:.:..:......:.::.|||:.:.:: ..|:.|..
  Fly   369 SSGAFTRYAISTACGLRTPMANLYLGIIVLLALSYLSPYFNYIPEATLAAILICSI-FTLLDFKL 432

Mouse   451 IGRLWKKDKYDCLIWIMTFIFAIVLGLGLGLAASVAFQLLTIVFRTQFPKCSTLANVGRSNIYK- 514
            ..|||:..|.|...|::.|..:::.|:.:||..|:....|.::|....|:.       |..|.:
  Fly   433 PMRLWRDSKRDFATWLLCFCVSVLFGVEVGLFVSIVVTALHLLFLWARPEI-------RVKIEQL 490

Mouse   515 NKKNYAEVYEPEGVKIFRCPSPIYFANIGFFKQKLIDA---------VGFSPLRILRKRNKALKK 570
            ::..|..|....|         |||..|.:.:::::.|         |.....||......|.:.
  Fly   491 DEMQYIRVTPSNG---------IYFPAINYLRERVLKACEQADFRITVVIDGQRISGMDYTAAQG 546

Mouse   571 IRKLQKRGLIQMTPKGFICTSDGFKDSDEELDNNQI-----EELDQPINTTD-LPFDIDWNGDLP 629
            |.||               :||..:.:|.......|     |.|.:.|:.|| |.|....|
  Fly   547 ISKL---------------SSDLCRQADASSSTLLILFRFPEHLQRLIDNTDNLVFCESEN---- 592

Mouse   630 LNITIPKISLHSLILDFSAVSFLDVSSMRGLRTILQEFIRIKVDV-YIVGTD 680
                  |:.           .||...|:|.....|:|.||..:|: |.:..|
  Fly   593 ------KVK-----------EFLTQESLRNGYINLKEHIRASIDLGYKIDID 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slc26a3	NP_067328.1	Sulfate_transp	73..468	CDD:366367	105/424 (25%)
Slc26a3	NP_067328.1	STAS_SulP_like_sulfate_transporter	519..705	CDD:132913	39/178 (22%)
CG5404	NP_650482.1	sulP	50..557	CDD:273284	139/576 (24%)
CG5404	NP_650482.1	STAS_SulP_like_sulfate_transporter	498..>554	CDD:132913	15/79 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0659
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000041
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X49
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.810