DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CLVS2 and CG13893

DIOPT Version :9

Sequence 1:	NP_001010852.2	Gene:	CLVS2 / 134829	HGNCID:	23046	Length:	327	Species:	Homo sapiens
Sequence 2:	NP_612042.3	Gene:	CG13893 / 38074	FlyBaseID:	FBgn0035146	Length:	407	Species:	Drosophila melanogaster

Alignment Length:	255	Identity:	59/255 - (23%)
Similarity:	110/255 - (43%)	Gaps:	31/255 - (12%)

- Green bases have known domain annotations that are detailed below.

Human    50 DDAFILRFLRARKFHHFEAFRLLAQYFEYRQQ-NLDMFKSFKATDPGIKQALKDGFPGGLANLDH 113
            ||.|::|:|||||::...|.::|....:.|.. |:|..:.:   ||  .:||::..|.||...|:
  Fly    32 DDYFLVRWLRARKWNLEAAEKMLRASLKTRAMWNVDNIEKW---DP--PKALQEYLPYGLMGYDN 91

Human   114 YGRKILVLFAANWDQ-------SRYTLVDILRAILLSLEAMIEDPELQVNGF-----VLIIDWSN 166
            .|..:||...||:|.       :|:.....| .:||.....|...:.|.:|:     |:..|..:
  Fly    92 EGSPVLVCPFANFDMWGMMHCVTRFEFQKYL-VLLLERFMKIAYDQSQKHGWRARQLVVFFDMQD 155

Human   167 FTFKQ-ASKLTPSMLRLAIEGLQDSFPARFGGIHFVNQPWYIHALYTVIRPFLKEKTRKRIFLHG 230
            ...|| |.:.....:...::..:.:||......:.:|.|......:.:::.||.|.|..:|.::.
  Fly   156 VNLKQYAWRPAAECVISTVKQYEANFPELLKMCYIINAPKLFSVAFNIVKKFLDENTTSKIVIYK 220

Human   231 NNLN----SLHQLIHPEILPSEFGGMLPPYD-------MGTWARTLLDHEYDDDSEYNVD 279
            :.::    .|...::.:..|..:||.:...:       :..|...|.:..|.|.|....|
  Fly   221 SGVDRWQEQLFSHVNRKAFPKAWGGEMVDRNGDPQCKALMVWGGKLPEELYIDQSSQQSD 280

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CLVS2	NP_001010852.2	CRAL_TRIO_N	29..75	CDD:215024	11/24 (46%)
		SEC14	106..251	CDD:238099	32/161 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	287..327
CG13893	NP_612042.3	CRAL_TRIO_N	16..57	CDD:215024	11/24 (46%)
		SEC14	75..246	CDD:238099	36/171 (21%)
		GOLD_2	303..381	CDD:290608
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810