DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CLVS2 and CG10026

DIOPT Version :9

Sequence 1:	NP_001010852.2	Gene:	CLVS2 / 134829	HGNCID:	23046	Length:	327	Species:	Homo sapiens
Sequence 2:	NP_609968.3	Gene:	CG10026 / 35226	FlyBaseID:	FBgn0032785	Length:	299	Species:	Drosophila melanogaster

Alignment Length:	252	Identity:	70/252 - (27%)
Similarity:	129/252 - (51%)	Gaps:	2/252 - (0%)

- Green bases have known domain annotations that are detailed below.

Human    10 PETLEKARLELNENPDTLHQDIQEVRDMVITRPDIGFLRTDDAFILRFLRARKFHHFEAFRLLAQ 74
            ||.:.:...|..|.|.:..:.|::.|:.::...:....|:|..::.:|||||.:....:::||..
  Fly    25 PEHIRRLAQEQGECPSSKDKVIEQFRNYILEHNECQPHRSDAKYLEKFLRARYWKIENSYKLLCS 89

Human    75 YFEYRQQNLDMFKSFKATDPGIKQALKDGFPGGLANLDHYGRKILVLFAANWDQSRYTLVDILRA 139
            |:.:|:||...::..:..|  ::...:..........|.:|.:||:.....|..::.|:.||.||
  Fly    90 YYRFREQNKSFYEKVRPLD--LRHVGQSDILTVTPYRDQHGHRILIYRFGLWRPNQVTVDDIFRA 152

Human   140 ILLSLEAMIEDPELQVNGFVLIIDWSNFTFKQASKLTPSMLRLAIEGLQDSFPARFGGIHFVNQP 204
            .::..|....:|..|:.|.|.|.|..:...:....|:||:.:..|..|..|.|.|...:|.|||.
  Fly   153 TIVLQELGSLEPISQIVGGVGIFDLKDLGLEHILHLSPSVAQKMIALLVTSMPIRTSALHIVNQN 217

Human   205 WYIHALYTVIRPFLKEKTRKRIFLHGNNLNSLHQLIHPEILPSEFGGMLPPYDMGTW 261
            |..:|.:.:.:|||....|:::::||:::.|||:.|:||.||..:||:...|....|
  Fly   218 WVFNAAFKIFKPFLNAAMREKLYIHGSDMTSLHKHINPEHLPKRYGGLHEDYSYTLW 274

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CLVS2	NP_001010852.2	CRAL_TRIO_N	29..75	CDD:215024	11/45 (24%)
		SEC14	106..251	CDD:238099	45/144 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	287..327
CG10026	NP_609968.3	CRAL_TRIO_N	43..90	CDD:215024	11/46 (24%)
CG10026	NP_609968.3	SEC14	112..265	CDD:238099	46/152 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D559280at33208
OrthoFinder	1	1.000	-	-		FOG0000233
OrthoInspector	1	1.000	-	-		mtm8539
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X106
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.820