DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CLVS2 and CG10237

DIOPT Version :9

Sequence 1:	NP_001010852.2	Gene:	CLVS2 / 134829	HGNCID:	23046	Length:	327	Species:	Homo sapiens
Sequence 2:	NP_609967.1	Gene:	CG10237 / 35222	FlyBaseID:	FBgn0032783	Length:	324	Species:	Drosophila melanogaster

Alignment Length:	270	Identity:	84/270 - (31%)
Similarity:	142/270 - (52%)	Gaps:	11/270 - (4%)

- Green bases have known domain annotations that are detailed below.

Human    14 EKARLELNENPDTLHQDIQEVRDMVITRPDIGFLRTDDAFILRFLRARKFHHFEAFRLLAQYFEY 78
            |.|..||.|.|:...:..:|:..::....|:.:.:.::.:::|:||..|::...|..|:.:|:.:
  Fly    54 EVAIKELRETPERQKEASKELARLLEAETDLLYPKGNEEWLIRYLRPCKYYPESARDLIKRYYAF 118

Human    79 RQQNLDMFKSFKATDPG--IKQALKDGFPGGLANLDHYGRKILVL-FAANWDQSRYTLVDILRAI 140
            :.::.|::...|.::..  .|..:...||    |.|..||:|||| ....|...:.||.::.:..
  Fly   119 KVKHADVYTDLKPSNEANIFKHNILTVFP----NRDQLGRRILVLELGKRWKHKQVTLDEVFKGA 179

Human   141 LLSLEAMIEDPELQVNGFVLIIDWSNFTFKQASKLTPSMLRLAIEGLQDSFPARFGGIHFVNQPW 205
            :|.|||.:.:||.|:.|.|:|.|....:.:|..:.||...:..::.||||.|.|...||.||||.
  Fly   180 VLFLEAAMLEPETQICGAVVIFDMDGLSLQQTWQFTPPFAKRIVDWLQDSVPLRIKAIHIVNQPK 244

Human   206 YIHALYTVIRPFLKEKTRKRIFLHGNNLNSLHQLIHPEILPSEFGGM--LPPYDMGTWARTLL-- 266
            ....::.:.:||||||.|.||..||.:..|||:.:.|:.||:.:||.  ....|...|.:.||
  Fly   245 IFQVVFALFKPFLKEKLRSRIIFHGTDRESLHKYMSPKCLPAAYGGFREASRIDSDQWYQLLLKC 309

Human   267 DHEYDDDSEY 276
            |.|:|..:.|
  Fly   310 DTEFDTINSY 319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CLVS2	NP_001010852.2	CRAL_TRIO_N	29..75	CDD:215024	8/45 (18%)
		SEC14	106..251	CDD:238099	54/145 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	287..327
CG10237	NP_609967.1	CRAL_TRIO_N	68..115	CDD:215024	8/46 (17%)
CG10237	NP_609967.1	SEC14	137..290	CDD:238099	57/156 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59833
OrthoDB	1	1.010	-	-		D559280at33208
OrthoFinder	1	1.000	-	-		FOG0000233
OrthoInspector	1	1.000	-	-		mtm8539
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5179
SonicParanoid	1	1.000	-	-		X106
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.860