DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CLVS2 and CG5958

DIOPT Version :9

Sequence 1:	NP_001010852.2	Gene:	CLVS2 / 134829	HGNCID:	23046	Length:	327	Species:	Homo sapiens
Sequence 2:	NP_609119.2	Gene:	CG5958 / 34022	FlyBaseID:	FBgn0031913	Length:	294	Species:	Drosophila melanogaster

Alignment Length:	290	Identity:	86/290 - (29%)
Similarity:	156/290 - (53%)	Gaps:	24/290 - (8%)

- Green bases have known domain annotations that are detailed below.

Human     3 HLQAG-LSPETLEKARLELNENPDTLHQDIQEVRDMVITRPDIGFLRTDDAFILRFLRARKFHHF 66
            ||:.| |.|||:|.||:||.|..:...:.|.::|:::...|::.: :.||||:..||||..|:..
  Fly    12 HLRLGYLKPETVEIARVELRETEEVKAEAIIKLRELLKATPELNY-KDDDAFLTVFLRACHFYPE 75

Human    67 EAFRLLAQYFEYRQQNLDMFKSFKATDPGIKQALKDGFPGG-----LANLDHYGRKILVLFAAN- 125
            .|...:.....:|::...:.:..      :.:.:|:.|..|     |.|.|..||::|::....
  Fly    76 GALEKMKTTASFRKEYASLVRGL------LVEQVKEKFVKGSVINVLKNCDQKGRRVLIVNCGKL 134

Human   126 WDQSRYTLVDILRAI-LLSLEAMIEDPELQVNGFVLIIDWSNFTFKQASKLTPSMLRLAIEGLQD 189
            ||.|..|..::.|.: ::.|.|.:|: |.||.|.|.|:|:...:.||...|:||..:..:..:|:
  Fly   135 WDPSDITSDEMFRMLYMVHLAAQLEE-ETQVRGVVCIMDFEGLSMKQVKALSPSFSKRLLTFIQE 198

Human   190 SFPARFGGIHFVNQPWYIHALYTVIRPFLKEKTRKRIFLHGNNLNSLHQLIHPEILPSEFGGMLP 254
            :.|.|...:|||.||:..:.::::.:||:|:|...|:..||:::.||.:.:.|.:||:.:.|.||
  Fly   199 AMPLRMKEVHFVKQPFIFNMVWSLFKPFVKQKLNNRMHFHGSDMKSLQKFLDPSVLPANYKGTLP 263

Human   255 PYDMG--TWARTLLDHEYDDDSEYNVDSYS 282
            ..|.|  .|...|     :..::| |:.:|
  Fly   264 AIDYGGVEWFPAL-----EQQAQY-VEEWS 287

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CLVS2	NP_001010852.2	CRAL_TRIO_N	29..75	CDD:215024	13/45 (29%)
		SEC14	106..251	CDD:238099	47/151 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	287..327
CG5958	NP_609119.2	CRAL_TRIO_N	38..82	CDD:215024	13/44 (30%)
CG5958	NP_609119.2	CRAL_TRIO	111..261	CDD:279044	46/150 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59833
OrthoDB	1	1.010	-	-		D559280at33208
OrthoFinder	1	1.000	-	-		FOG0000233
OrthoInspector	1	1.000	-	-		mtm8539
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X106
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.830