DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CLVS2 and CG31636

DIOPT Version :9

Sequence 1:	NP_001010852.2	Gene:	CLVS2 / 134829	HGNCID:	23046	Length:	327	Species:	Homo sapiens
Sequence 2:	NP_001285685.1	Gene:	CG31636 / 318865	FlyBaseID:	FBgn0051636	Length:	313	Species:	Drosophila melanogaster

Alignment Length:	241	Identity:	72/241 - (29%)
Similarity:	122/241 - (50%)	Gaps:	15/241 - (6%)

- Green bases have known domain annotations that are detailed below.

Human    19 ELNENPDTLHQDIQEVRDMVITRPDIGFLR--TDDAFILRFLRARKFHHFEAFRLLAQYFEYRQQ 81
            ||||.|..:.|||:.:||.|:.:|   .||  |||.|:|.|||..||....|.....:::..::.
  Fly    18 ELNELPARMAQDIEALRDWVLKQP---HLRACTDDQFLLAFLRGTKFSLERAKEKFDRFYTLQRS 79

Human    82 NLDMFKSFK-ATDPGIKQALKDG----FPGGLANLDHYGRKILVLFAANWDQSRYTLVDILRAIL 141
            ..::|...: ||||.:...::.|    .|   .:.|..|.::.::.|.::|.|::...||:|...
  Fly    80 IPEVFNERRLATDPQVLDIVRMGVLLQIP---MDADDPGPRVTIIRAGSYDTSKHKFQDIIRVGS 141

Human   142 LSLEAMI-EDPELQVNGFVLIIDWSNFTFKQASKLTPSMLRLAIEGLQDSFPARFGGIHFVNQPW 205
            :..|.|: ||....|:|:|.|:|.:..|......|.|.:|........::.|.|..||||:|.|.
  Fly   142 MFGEIMMFEDDNATVSGYVEIMDMAGVTGSHLFALQPQLLSKFSTYADEAMPTRQKGIHFINVPA 206

Human   206 YIHALYTVIRPFLKEKTRKRIFLHGNNLNSLHQLIHPEILPSEFGG 251
            .....:..:|.|...|.:.||.: .::..::::|:..:.||.|:||
  Fly   207 AFETGFNSLRSFFPAKIKSRISV-SSDPAAIYELVRRKYLPQEYGG 251

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CLVS2	NP_001010852.2	CRAL_TRIO_N	29..75	CDD:215024	20/47 (43%)
		SEC14	106..251	CDD:238099	38/145 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	287..327
CG31636	NP_001285685.1	CRAL_TRIO_N	27..72	CDD:215024	20/47 (43%)
CG31636	NP_001285685.1	SEC14	96..252	CDD:238099	42/160 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145904
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D559280at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X106
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840