DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CLVS2 and CG3091

DIOPT Version :9

Sequence 1:	NP_001010852.2	Gene:	CLVS2 / 134829	HGNCID:	23046	Length:	327	Species:	Homo sapiens
Sequence 2:	NP_001284816.1	Gene:	CG3091 / 31210	FlyBaseID:	FBgn0029608	Length:	303	Species:	Drosophila melanogaster

Alignment Length:	269	Identity:	66/269 - (24%)
Similarity:	131/269 - (48%)	Gaps:	44/269 - (16%)

- Green bases have known domain annotations that are detailed below.

Human     9 SPETLEKARLELNENPDTLHQDIQEVRDMVI---TRPDIGFLRTDDAFILRFLRARKFHHFEAFR 70
            :|||        :.:|.|...|  ::.|:|.   ..|::. .:.:...:||||:...| ..|..:
  Fly    11 APET--------SASPATGWSD--KLTDLVAWFEANPNLP-EKIEPIVMLRFLKCTAF-DVERTK 63

Human    71 LLAQYFEYRQQN------LDMFKSFKATDPGIKQA----LKDGFPGG-------LANLDHYGR-- 116
            .||: ..|..:|      :|.....:.|..|::.:    |....|.|       :|:||...|
  Fly    64 ALAE-LNYCMRNKSPHLFMDRNMEDEMTAEGLRVSDLLILPGVTPQGNKLIFFRMADLDPRTRNS 127

Human   117 ----KILVLFAANWDQSRYTLVDILRAILLSLEAMIEDPELQVNGFVLIIDWSNFTFKQASKLTP 177
                ||.|:.:    .:|:|..|:.|......:.::::.:: ..|.|.|:|...:|.:..:.::.
  Fly   128 VEETKIFVMMS----DARFTKPDVERETGSGADYVLDEADI-AEGDVQIVDIGGYTLRHLAYVSI 187

Human   178 SMLRLAIEGLQDSFPARFGGIHFVNQPWYIHALYTVIRPFLKEKTRKRIFLHGNNLNSLHQLIHP 242
            .:||:.::.||:::|:|...:|.:|.|.|:..|.:::.|||:|:.|..|..|...::||::.:..
  Fly   188 FVLRVYMKFLQEAYPSRLQAMHVINCPTYLDKLISMMSPFLREEVRNMIRYHTEGMDSLYKEVPR 252

Human   243 EILPSEFGG 251
            ::||:|:||
  Fly   253 DMLPNEYGG 261

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CLVS2	NP_001010852.2	CRAL_TRIO_N	29..75	CDD:215024	12/48 (25%)
		SEC14	106..251	CDD:238099	40/157 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	287..327
CG3091	NP_001284816.1	SEC14	101..262	CDD:238099	44/166 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145894
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D559280at33208
OrthoFinder	1	1.000	-	-		FOG0000233
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.750