Protein Alignment Dnmt3a and sba

DIOPT Version :10

• Sequence 1: NP_031898.1
• Gene: Dnmt3a / 13435
• MGIID: 1261827
• Length: 908
• Species: Mus musculus
• Sequence 2: NP_001262888.1
• Gene: sba / 42824
• FlyBaseID: FBgn0016754
• Length: 1606
• Species: Drosophila melanogaster
• Alignment Length: 475
• Identity: 102/475 - (21%)
• Similarity: 149/475 - (31%)
• Gaps: 164/475 - (34%)

Mouse    38 PSATARKVGRPGRKRKHPPVESSDTPKDPAVTTKSQPMAQDSGPSDLLP-----------NGDLE 91
            |.||..::       ::.|..|..||:.|.:.....|   .:.||.:.|           ||.|.
  Fly  1064 PDATLLQI-------QNMPATSLMTPQGPVMLRTPSP---QNKPSFISPSAGGQQYLVGANGQLS 1118

Mouse    92 KRSE--PQPEEGSPAAGQKGGAP-AEGEGTET------------------PPEASRAVENGCCVT 135
            ...:  ..|.......||:|||. .:...|.|                  |.:|:...|.  .::
  Fly  1119 PIGQIYSTPMGLVMPTGQQGGASFVQASPTTTTIQIQQQPAPQPTQISLQPAQATYMTET--VMS 1181

Mouse   136 KEGRGAS------------------AGEGKEQKQTNIESMKMEGSRGRLRGGLGWESSLRQRPMP 182
            ::|..||                  ...|.:..|. :.|.:.:.:..        ..|...|..|
  Fly  1182 RQGTAASPPDTTTCSPRSPERPSSHRSSGSDMVQC-VSSSEPDAAVS--------PQSTESRQSP 1237

Mouse   183 RLT-----------FQAGDPYYISKRKRDEWLARWKREAEKKAKVIAVMNAVEENQASGESQKVE 236
            ..|           |......|              :.:|.|.:.|.:.:  :.:..:|.|....
  Fly  1238 SSTDCERSICKNNVFTQPSGIY--------------KHSEPKIRRIHITS--QTSAENGISLMQG 1286

Mouse   237 EASPPAVQ--------QPTDPASPTVATTP-----EPVGGDAGDKNATKAADDEPEYEDGRGFGI 288
            :.||...|        |||  ...|...||     .|..|.|   .|..:|.|:......|.|.|
  Fly  1287 QESPTTTQLLSSVPTAQPT--VEKTTVRTPTKRSRRPQRGAA---RAAPSASDKSFPLPPRSFAI 1346

Mouse   289 GELVWGKLRGFSWWPGRIVSWWMTGRSRAAEGT---------RWVMWFGDGKFS---VVCVEKLM 341
            |||:||..||...|||:||        :..:|.         .||.|||.|..|   ::.|..|.
  Fly  1347 GELIWGPARGHPAWPGKIV--------KMPDGVCTPSQQFDHVWVQWFGGGGRSTSELIPVNSLQ 1403

Mouse   342 PLSSFCSAFHQA--------TYNKQPMYRKAIYEVLQVASSRAGKLFPACHDSDE-------SDS 391
            .||....|.|:|        ..|.|  ..:||.|.:....:.:....||...|..       :.:
  Fly  1404 SLSEGLEAHHKAQKDTRKSRKLNSQ--LERAIQEAMTELDNISASSTPAATSSSSATISAVPASA 1466

Mouse   392 GKAVEVQNKQMIEWALGGFQ 411
            |.||           :||.|
  Fly  1467 GPAV-----------IGGQQ 1475

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dnmt3a	NP_031898.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..183		34/194 (18%)
		PTZ00449	<1..>121	CDD:185628	23/114 (20%)
		2A1904	<17..>282	CDD:273344	58/317 (18%)
		Interaction with DNMT1 and DNMT3B. /evidence=ECO:0000250	195..399		61/243 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	226..281		17/67 (25%)
		PWWP_DNMT3A	281..414	CDD:438982	44/158 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	443..462
		ADDz_Dnmt3a	483..610	CDD:277255
		Interaction with the PRC2/EED-EZH2 complex. /evidence=ECO:0000269|PubMed:16357870	490..582
		Dcm	627..905	CDD:440040
sba	NP_001262888.1	MBD	241..315	CDD:128673
		PWWP_MBD5	1344..1441	CDD:438969	34/106 (32%)