Protein Alignment Dmd and dah

DIOPT Version :10

• Sequence 1: XP_006527830.1
• Gene: Dmd / 13405
• MGIID: 94909
• Length: 3696
• Species: Mus musculus
• Sequence 2: NP_511162.1
• Gene: dah / 32459
• FlyBaseID: FBgn0015926
• Length: 649
• Species: Drosophila melanogaster
• Alignment Length: 638
• Identity: 133/638 - (20%)
• Similarity: 209/638 - (32%)
• Gaps: 191/638 - (29%)

Mouse  3090 DLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPM-DILQIINCLTTIYDR 3153
            |..|.:::.||.|.|...|||......:........||:|||....:.| ...|:.:.|..:|..
  Fly    53 DYGNYKYTVYRCASKFVALQKIFHTGKIPYKLVLAILDRHNLSGGLELMVPPFQLTSLLHDVYFA 117

Mouse  3154 LEQ--EHNNLVNVPL--CVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKY------ 3208
            .|:  ..|...|..|  ...:..|:..||||..|...|.:|..:...|.|||.:..|..
  Fly   118 CEKLGHFNQDANYKLDRATGLLANFFWNVYDPQRRHSISLLEIRITFILLCKLYSSDHLVGDIFG 182

Mouse  3209 -----------RYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQF 3262
                       ||.|:|:.::        |..||       ..|||..::|..|:..::..||.
  Fly   183 LLADPKSQIISRYAFEQLLAT--------LSKLL-------SYLGEAKAYGVHNLPLAMEQCFA- 231

Mouse  3263 ANNKPEIEAALFLDWMRLEPQ-SMVW---------------LPVLHRVAAAETAKHQAKCNICKE 3311
              ..|.....|      .||| ..:|               |.::.|:...|...|...|..|::
  Fly   232 --RCPHGVGGL------TEPQFHKLWTGAGVQTRFLIYGNLLALVKRIEDTEHLIHSNSCAGCRK 288

Mouse  3312 CPIIGFRYRSLKHFNYDICQSC----FFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNK 3372
            ..|:|.|:|.....:..:|..|    |..||...||:|....||...|
  Fly   289 EHIVGIRFRCQVCRDISLCLPCFAVGFAGGRHEPGHRMCEVFVEDQPP----------------- 336

Mouse  3373 FRTKRYFAKHPRMGYLPVQTVLE---------------GDNMETPVTLINFWPVDSAPASSPQLS 3422
            .|..|:.|:......:|.:|..|               |.:..||:      |.::....|....
  Fly   337 LRWTRHLARLCGWLVMPRKTQEEERRGFCNAQESGPALGQSAATPI------PAETRSVRSQCQE 395

Mouse  3423 HDDT--------------------HSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQH 3467
            .|.|                    .||::....||. ::|:.......:::...|.:....|..|
  Fly   396 KDRTVVLQQQQQELCSLTGLASEASSRLQSIIDRLL-LQNAKLETQLQTVATASSSEISQFLSAH 459

Mouse  3468 YC----------QSLNQDSPLSQPRSPA-----------------------QILISLESEERGEL 3499
            .|          |..:..:..|.|.:||                       |:|..:.:.....|
  Fly   460 QCFLLQIIEDMRQLSHASAVTSPPPAPAAQVAPSAAPLVSSTFLSSSTPQRQMLFDMYAPVGANL 524

Mouse  3500 ERIL--ADLE----EENR------NLQAEYDRLK---QQHEHKGLSPLPSP---P-----EMMPT 3541
            ...:  |||.    |.|:      ::...:|:.:   |..:..|..|.|.|   |     |..|.
  Fly   525 THSINGADLNRSYLEANKSDYSLNDISLWFDQRRSSVQPGQGPGSLPAPLPLPMPLGALLEQQPA 589

Mouse  3542 SPQSPRDAELIAEAKLLRQHKGRLEARMQILED---HNKQLESQLHRLRQLLE 3591
            :....||.|::....||.:.|       :|:||   .|.:|.:....|..:|:
  Fly   590 NGGDGRDTEMVNFKLLLHKVK-------EIVEDSYSDNAELSAATQNLENVLD 635

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dmd	XP_006527830.1	CH_DMD_rpt1	11..121	CDD:409080
		CH_DMD_rpt2	136..246	CDD:409082
		SPEC	346..560	CDD:238103
		SPEC	562..829	CDD:413338
		SPEC	729..935	CDD:238103
		SPEC	945..1154	CDD:238103
		SPEC	1051..1265	CDD:238103
		SMC_prok_B	1128..>1938	CDD:274008
		SPEC	2107..2317	CDD:238103
		SPEC	2465..2681	CDD:238103
		SPEC	2683..2926	CDD:238103
		Spectrin	2927..3033	CDD:395348
		WW	3052..3081	CDD:238122
		EFh_DMD	3118..3279	CDD:320004	42/182 (23%)
		EF-hand-like motif	3118..3157	CDD:320004	10/41 (24%)
		EF-hand-like motif	3164..3198	CDD:320004	9/35 (26%)
		EF-hand-like motif	3204..3240	CDD:320004	8/52 (15%)
		EF-hand-like motif	3253..3279	CDD:320004	4/25 (16%)
		ZZ_dystrophin	3304..3352	CDD:239074	15/51 (29%)
dah	NP_511162.1	EFh_DAH	81..250	CDD:320003	45/192 (23%)
		EF-hand-like motif	81..120	CDD:320003	9/38 (24%)
		EF-hand-like motif	132..166	CDD:320003	9/33 (27%)
		EF-hand-like motif	173..210	CDD:320003	8/51 (16%)
		EF-hand-like motif	223..250	CDD:320003	7/35 (20%)
		ZZ_dah	281..329	CDD:239085	14/47 (30%)