DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dlg4 and dlg1

DIOPT Version :9

Sequence 1:	NP_001357604.1	Gene:	Dlg4 / 13385	MGIID:	1277959	Length:	764	Species:	Mus musculus
Sequence 2:	NP_001162718.1	Gene:	dlg1 / 32083	FlyBaseID:	FBgn0001624	Length:	1030	Species:	Drosophila melanogaster

Alignment Length:	703	Identity:	302/703 - (42%)
Similarity:	399/703 - (56%)	Gaps:	154/703 - (21%)

- Green bases have known domain annotations that are detailed below.

Mouse    26 LLTVLHSDLFQALLDILDYYEAC------------------------------ISESQKYRYQDE 60
            ::.:..|.||||||||.::||..                              |:::|:.|. :.
  Fly   334 VIRIFKSRLFQALLDIQEFYELTLLDDSKSIQQKTAETLQIATKWEKDGQAVKIADNQRMRI-ES 397

Mouse    61 DT-----PPLEHS---------PAHLPNQANSPPVIVNTDTLEAPGYVNGTEGEMEYEEITLERG 111
            ||     |.:|..         .:..|.|.| |.....:.:......|||.:..: ||:|.||||
  Fly   398 DTENAKEPTVEQQQKQQQAQQRSSRSPQQQN-PQQQQGSKSRSGSQTVNGDDSWL-YEDIQLERG 460

Mouse   112 NSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEA 176
            ||||||||||||||||||.|.||:|||:|.|||||.||||.:||.|:.||:|.|.:|.|::||:|
  Fly   461 NSGLGFSIAGGTDNPHIGTDTSIYITKLISGGAAAADGRLSINDIIVSVNDVSVVDVPHASAVDA 525

Mouse   177 LKEAGSIVRLYVMRRKPPA-------------------EKIIEIKLIKGPKGLGFSIAGGVGNQH 222
            ||:||::|:|:|.|::..|                   .|:|||.|:||.||||||||||:||||
  Fly   526 LKKAGNVVKLHVKRKRGTATTPAAGSAAGDARDSAASGPKVIEIDLVKGGKGLGFSIAGGIGNQH 590

Mouse   223 IPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVG----LEDVMHEDAVAALKNTYDVVYLKV 283
            |||||.|||||:::||||..||||.||||::||.:.|    ||:|.||.|||.||:..|.|.|.:
  Fly   591 IPGDNGIYVTKLMDGGAAQVDGRLSIGDKLIAVRTNGSEKNLENVTHELAVATLKSITDKVTLII 655

Mouse   284 AK----------------PSNAYLSDSYAPPDITTSYSQHLDNEISH-------------SSYLG 319
            .|                .|...||.|.:  .:.||.||...::..|             |.|..
  Fly   656 GKTQHLTTSASGGGGGGLSSGQQLSQSQS--QLATSQSQSQVHQQQHATPMVNSQSTEPGSRYAS 718

Mouse   320 TDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAG 384
            |:...|:.|.:||..|        .|||.||||.|.|.:|..||||||||||||:||::||||||
  Fly   719 TNVLAAVPPGTPRAVS--------TEDITREPRTITIQKGPQGLGFNIVGGEDGQGIYVSFILAG 775

Mouse   385 GPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLRE 449
            |||||..||::|||:||||.|:|.:|:||:||.|||.:|..||::|||:||||:||||:|.:|::
  Fly   776 GPADLGSELKRGDQLLSVNNVNLTHATHEEAAQALKTSGGVVTLLAQYRPEEYNRFEARIQELKQ 840

Mouse   450 QLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKDCGFLSQALSFHFGDVLHVIDASDEEWWQAR 514
            |....:.||||. ||:..||..|:|||||||..:|.|..|:.|.|..||:|||.:|||:||||||
  Fly   841 QAALGAGGSGTL-LRTTQKRSLYVRALFDYDPNRDDGLPSRGLPFKHGDILHVTNASDDEWWQAR 904

Mouse   515 RVHSDSETDDIGFIPSKRRVERREWSRLKAKDWGSSSGSQGREDSVLSYETVTQMEVHYARPIII 579
            ||..|:|.:.||.:|||||.||    :::|:|  .|...||                |.|
  Fly   905 RVLGDNEDEQIGIVPSKRRWER----KMRARD--RSVKFQG----------------HAA----- 942

Mouse   580 LGPTKDRANDDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKD 632
                   ||::|     ||..:    ..|.|:.:.. .|.:.|:.||::..:|
  Fly   943 -------ANNNL-----DKQST----LDRKKKNFTF-SRKFPFMKSRDEKNED 978

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlg4	NP_001357604.1	L27	<26..47	CDD:351851	10/20 (50%)
		MAGUK_N_PEST	54..104	CDD:337803	12/63 (19%)
		PDZ	105..189	CDD:334167	57/83 (69%)
		PDZ	197..287	CDD:214570	60/109 (55%)
		PDZ_assoc	285..352	CDD:313755	23/95 (24%)
		PDZ	350..434	CDD:214570	56/83 (67%)
		SH3_DLG4	470..535	CDD:212963	38/64 (59%)
		Guanylate_kin	573..751	CDD:279019	13/60 (22%)
dlg1	NP_001162718.1	L27_1	303..359	CDD:286187	11/24 (46%)
		PDZ	454..540	CDD:214570	58/85 (68%)
		PDZ_signaling	566..655	CDD:238492	58/88 (66%)
		PDZ_signaling	742..820	CDD:238492	52/77 (68%)
		SH3_DLG-like	862..922	CDD:212795	35/59 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836160
Domainoid	1	1.000	122	1.000	Domainoid score	I5623
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	893	1.000	Inparanoid score	I387
Isobase	1	0.950	-	0	Normalized mean entropy	S1843
OMA	1	1.010	-	-		QHG52541
OrthoDB	1	1.010	-	-		D349551at33208
OrthoFinder	1	1.000	-	-		FOG0000833
OrthoInspector	1	1.000	-	-		otm42342
orthoMCL	1	0.900	-	-		OOG6_101347
Panther	1	1.100	-	-	O	PTHR23119
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X574
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.720