Protein Alignment EGFLAM and egflam

DIOPT Version :10

• Sequence 1: NP_001192230.1
• Gene: EGFLAM / 133584
• HGNCID: 26810
• Length: 1017
• Species: Homo sapiens
• Sequence 2: XP_073808033.1
• Gene: egflam / 799405
• ZFINID: ZDB-GENE-070705-525
• Length: 1095
• Species: Danio rerio
• Alignment Length: 1032
• Identity: 609/1032 - (59%)
• Similarity: 785/1032 - (76%)
• Gaps: 45/1032 - (4%)

Human    26 RAAIRKPGKVGPPLDIKLGALNCTAFSIQWKMPRHPGSPILGYTVFYSEVGADKSLQEQ-LHSVP 89
            ::..||..::.|||||:|..:||||||::|||||...|.|.||.|||:|:..::..... :..||
Zfish    64 KSGARKSERLSPPLDIQLETVNCTAFSVRWKMPRRHVSTITGYKVFYTEMRNNRPTSNAVVLEVP 128

Human    90 LSRDIPTT---------EEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAP 145
            ||.::.||         :.|||:||..|:||||:.||..||:||.|.||.::|.|.:.|:|||.|
Zfish   129 LSLEMLTTGQFDGQASFDVVIGNLKVATQYRVSVGAYGWAGEGRPSMPRDISTGSHEKCMPPAPP 193

Human   146 QQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGLDPDT 210
            .||:|:.|||:|:|:||:.|.|:||||:.|:.|.:|||:.|.:||.|.|.::.:|||:|||.|:|
Zfish   194 TQPNVVAVSDTELAMSWQHGESDGSAPVLYFLVAYIRPEMDTEWTYIREPVESNSMVLKGLIPET 258

Human   211 NYQFAVRAMNSHGPSPRSWPSDIIRTLCPEEAGSGRYGPRYITDMGAGEDDEGFEDDLDLDISFE 275
            .|||.:||:|:||.||.|..::.:|||...:.|||.|.. ||::....::|:...||.|.|...|
Zfish   259 EYQFVIRAVNAHGISPPSAINNPVRTLGSVDTGSGDYDV-YISNSDNKDEDKLDIDDSDYDFFIE 322

Human   276 EVKPLPATKGGNKKFLVESKKMSISNPKTISRL---------IPPTSASLPVTTVAPQPI----- 326
            |:| .|::|...::..:.|:..:..|...|.|:         ..||:||:..||.....:
Zfish   323 EMK-FPSSKKSGRRSQLRSRIGTPGNGNVIYRMRTPVSPNISFTPTTASIWTTTTTTTTVTMTTT 386

Human   327 ------PIQRKGKNGVAIMS-------------RLFDMPCDETLCSADSFCVNDYTWGGSRCQCT 372
                  ||.|......|:.|             |::|:||:||:|.|||||:|||..|||||.|.
Zfish   387 SRTTATPIVRTATPPPAVPSSSPSMTPWKGERARVYDVPCEETVCPADSFCINDYDTGGSRCHCN 451

Human   373 LGKGGESCSEDIVIQYPQFFGHSYVTFEPLKNSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDF 437
            ||:.|:.|||.:.|.:|:|:|:|::||||||||||:|||:|||:|||||||||||||||||||||
Zfish   452 LGRQGDFCSEGLTINFPKFYGYSHMTFEPLKNSYQSFQISLEFKAEAEDGLLLYCGENEHGRGDF 516

Human   438 MSLAIIRRSLQFRFNCGTGVAIIVSETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYS 502
            .|||:||..|.:|||||||.|.|:|::.|.:|.||||.::|||:||.|:|:|.|||:.:|||||:
Zfish   517 TSLALIRGKLHYRFNCGTGAAQIISDSSIVIGQWHTVTIFRDGMNGWLRLDNDTPVSSRSQGQYT 581

Human   503 KITFRTPLYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSSG 567
            ||||||.|:|||||:.||||||.|||||||||:|||.||.:.||:||||.|.||||||:||||:.
Zfish   582 KITFRTALFLGGAPNGYWLVRAVGTNRGFQGCMQSLTVNSKAIDIRPWPKGNALSGADIGECSNS 646

Human   568 ICDEASCIHGGTCTAIKADSYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAATPWPLEPQHYL 632
            :|::.:|.:||.|.|.:||.:|||||||:||..||::|.|::|||.:|:.|||:.|||....:||
Zfish   647 VCEKVTCANGGICFANRADGFICLCPLGYKGFLCEESFLLSLPQFNQSMFSYASAPWPQSSHNYL 711

Human   633 SFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGNWHE 697
            ||||||:||:|.|.||.|||:.|..|:|||||:|..|:||||||||||..|:|||:.:.:..|||
Zfish   712 SFMEFEVTFQPTSPDGTLLYTDDATSRDFLSISLVAGYVEFRFDCGSGATVIRSEEAIAMNVWHE 776

Human   698 LRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKPFSGSIQKI 762
            |||||||||||||||.|:.|||||||.||||||::.::||||||||..|.::|:|:|:|||:|||
Zfish   777 LRVSRTAKNGILQVDNQRPVEGMAEGAFTQIKCSSPLYIGGVPNYDITKPSAGILRPYSGSVQKI 841

Human   763 ILNDRTIHVKHDFTSGVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKECGNYC 827
            .||||.|.:......||||.|||||||..|||:||:||.:.:.|||||.||::|.||||||||||
Zfish   842 TLNDRGIELNPGQAFGVNVLNAAHPCVDNPCANGGTCRAKWDEYDCDCALGYDGKHCQKECGNYC 906

Human   828 LNTIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFI 892
            |||:.|:||||||.|||||||||.|||||:||||:|:|||||:|:|||||||||:||||.|||::
Zfish   907 LNTVTESIEIPQFTGRSYLTYDNRDILKRISGSRTNLFMRFKSTSKDGLLLWRGESPMRANSDYL 971

Human   893 SLGLRDGALVFSYNLGSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQ 957
            ||||:||:|:||||||||.|::::||:|:||:||||||||||||||:|||||||:||:|||.|||
Zfish   972 SLGLQDGSLIFSYNLGSGAATVVINGTFSDGKWHRVKAVRDGQSGKLTVDDYGAQTGRSPGKMRQ 1036

Human   958 LNINGALYVGGMKEIALHTNRQYMRGLVGCISHFTLSTDYHISLVEDAVDGKNINTC 1014
            |||||.||:|||||||||||||||||||||||||||:||||:|||:|||||||||||
Zfish  1037 LNINGDLYIGGMKEIALHTNRQYMRGLVGCISHFTLATDYHLSLVDDAVDGKNINTC 1093

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EGFLAM	NP_001192230.1	FN3	36..133	CDD:238020	50/106 (47%)
		FN3	142..234	CDD:238020	48/91 (53%)
		LamG	391..541	CDD:238058	108/149 (72%)
		EGF_CA	560..602	CDD:238011	22/41 (54%)
		LamG	618..765	CDD:238058	96/146 (66%)
		EGF_CA	<792..820	CDD:238011	16/27 (59%)
		Laminin_G_2	868..993	CDD:460494	101/124 (81%)
egflam	XP_073808033.1	None