DRSC/TRiP Functional Genomics Resources

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Protein Alignment EGFLAM and trol

DIOPT Version :9

Sequence 1:NP_001192230.1 Gene:EGFLAM / 133584 HGNCID:26810 Length:1017 Species:Homo sapiens
Sequence 2:NP_001027038.3 Gene:trol / 45320 FlyBaseID:FBgn0284408 Length:4479 Species:Drosophila melanogaster


Alignment Length:1305 Identity:291/1305 - (22%)
Similarity:459/1305 - (35%) Gaps:421/1305 - (32%)


- Green bases have known domain annotations that are detailed below.


Human    13 LLASSLGPGAVSLRAAIRKPGKV------GPPL-----DIK------------LGALNCTAFS-- 52
            |||:.:|.. |:|...:.:|...      |.||     .||            ||...|....  
  Fly  3282 LLATDIGDN-VTLTCDMFQPLNTRWERVDGAPLPRNAYTIKNRLEIVRVEQQNLGQYRCNGIGRD 3345

Human    53 -----------IQWKMPR---HPGSPILGYTVFYSEVGADKSLQ--------EQLH-SVPLSRDI 94
                       :...:||   :|..|:   ||   |.|.:..:.        |.:| |...:|.:
  Fly  3346 GNVKTYFVKELVLMPLPRIRFYPNIPL---TV---EAGQNLDVHCQVENVRPEDVHWSTDNNRPL 3404

Human    95 PTTEEVIGDL--------KPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVI 151
            |::..::|.:        ....|||.|  |::|.| .|....|.......|....|.:..|.|  
  Fly  3405 PSSVRIVGSVLRFVSITQAAAGEYRCS--AFNQYG-NRSQIARVAVKKPADFHQVPQSQLQRH-- 3464

Human   152 VVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGLDPDTNYQFAV 216
                           .||                        |.||:...|..        |:.|
  Fly  3465 ---------------REG------------------------ENIQLQCTVTD--------QYGV 3482

Human   217 RAMNS---------HGPSPRSWPSD----IIRTLCPEEAGSGRY--------------------- 247
            ||.::         ..|.|.:..:|    ::..|.||:|  |||                     
  Fly  3483 RAQDNVEFNWFRDDRRPLPNNARTDSQILVLTNLRPEDA--GRYICNSYDVDRGQQLPEVSIDLQ 3545

Human   248 ---GPRY-----------------------------------------------------ITDMG 256
               .|:|                                                     .:::.
  Fly  3546 VLRAPQYPYNRFKGGVSLKDTPCMVLYICAAATPPPNSPIYLPPQLPAKSRDYSLKLDDQSSNLR 3610

Human   257 AGE--DDEGF-EDDLDLDISFEEVKPLPATKG----GNKKFLVESKKMSISNPKTISRLIPPTSA 314
            |||  |.|.: .||...|:.:|.....|.:..    ||        ::.|||       :.|:.|
  Fly  3611 AGESTDVECYSSDDTYTDVVWERSDGAPLSNNVRQVGN--------RLVISN-------VSPSDA 3660

Human   315 SLPV-----------TT-----VAPQP-------IPIQRKGKNGVAIMSRLFDMPCDETLCSADS 356
            ...|           ||     |..||       |...:.|.|.             :..|.||.
  Fly  3661 GNYVCKCKTDEGDLYTTSYKLEVEDQPHELKSSKIVYAKVGANA-------------DLQCGADE 3712

Human   357 FCVNDYTWGGSRCQCTLGKG--GESCSEDIV-----------IQY------------------PQ 390
            .....|.|.....|...|:.  .|..|.|.|           .||                  ||
  Fly  3713 SRQPTYRWSRQYGQLQAGRSLMNEKLSLDSVQANDAGTYICTAQYADGETADFPNILVVTGAIPQ 3777

Human   391 F--FGHSYVTFEPLKNSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNC 453
            |  ...||::|..|.||...|...|.||.|..|||||:.|:. .|.||:::|::..|..:|||:.
  Fly  3778 FRQEPRSYMSFPTLPNSSFKFNFELTFRPENGDGLLLFNGQT-RGSGDYIALSLKDRYAEFRFDF 3841

Human   454 GTGVAIIVSETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSA 518
            |....::.:|..:.|..||||.:.|...:|.:|::...||...:..|..::.....||:||.|: 
  Fly  3842 GGKPMLVRAEEPLALNEWHTVRVSRFKRDGYIQVDEQHPVAFPTLQQIPQLDLIEDLYIGGVPN- 3905

Human   519 YW-LVRATGTNR--GFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSSGICDEASCIHGGTC 580
             | |:.|...::  ||.||:..|.:.||.:::    :.:|.....:.:|..  |.:..|.:.|.|
  Fly  3906 -WELLPADAVSQQVGFVGCISRLTLQGRTVEL----IREAKYKEGITDCRP--CAQGPCQNKGVC 3963

Human   581 TAIKAD-SYICLCPLGFKGRHCEDAFTLTIP----------------------------QFRESL 616
            ...:.: :|.|:|..|:.||.|....|...|                            |:.|.|
  Fly  3964 LESQTEQAYTCICQPGWTGRDCAIEGTQCTPGVCGAGRCENTENDMECLCPLNRSGDRCQYNEIL 4028

Human   617 ---------RSYAATPWPLEPQHYLSFMEFEITFRPDS-GDGVLLYSYDT--GSKDFLSINLAGG 669
                     .|:||...|     .::.:...::.||.| .|.|:||:.::  .|.|:|::.|.||
  Fly  4029 NEHSLNFKGNSFAAYGTP-----KVTKVNITLSVRPASLEDSVILYTAESTLPSGDYLALVLRGG 4088

Human   670 HVEFRFDCGSGTG--VLRSEDPLTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNT 732
            |.|...:..:...  |:||.:||.|..|..:.:.|....|||:|......:..|.|....:...|
  Fly  4089 HAELLINTAARLDPVVVRSAEPLPLNRWTRIEIRRRLGEGILRVGDGPERKAKAPGSDRILSLKT 4153

Human   733 DIFIGGVPNYD----DVKKNSGVLKPFSGSIQKIILNDRTIHVKHDFTSGVNVEN---------- 783
            .:::||   ||    .|.::..:.|.|.|.|.::....:.:::..|.....|:::          
  Fly  4154 HLYVGG---YDRSTVKVNRDVNITKGFDGCISRLYNFQKPVNLLADIKDAANIQSCGETNMIGGD 4215

Human   784 ------------------------AAHPCVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKECG 824
                                    |..||...||.:||||..:::...|.||.||.|.|||    
  Fly  4216 EDSDNEPPVPPPTPDVHENELQPYAMAPCASDPCENGGSCSEQEDVAVCSCPFGFSGKHCQ---- 4276

Human   825 NYCLNTIIEAIEI---PQFIGRSYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMR 886
                    |.:::   ..|.|..|:..:.......:..|.:::.:.|.|...:|||.|.|.....
  Fly  4277 --------EHLQLGFNASFRGDGYVELNRSHFQPALEQSYTSMGIVFTTNKPNGLLFWWGQEAGE 4333

Human   887 --PNSDFISLGLRDGALVFSYNLGSGVASIMVNGSF--NDGRWHRVKAVRDGQSGKITVDDYGAR 947
              ...|||:..:.||.:.:|..| .|..:::.|...  ::|..|.|.|.||..:..:.||.. ..
  Fly  4334 EYTGQDFIAAAVVDGYVEYSMRL-DGEEAVIRNSDIRVDNGERHIVIAKRDENTAILEVDRM-LH 4396

Human   948 TGKS-PGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCISHFTLSTDYHISLVEDAVDGKNI 1011
            :|:: |...:.:.:.|.::|||..::.:.|..:|...|.|||......|...|:|...||:|.|.
  Fly  4397 SGETRPTSKKSMKLPGNVFVGGAPDLEVFTGFRYKHNLNGCIVVVEGETVGQINLSSAAVNGVNA 4461

Human  1012 NTCGA 1016
            |.|.|
  Fly  4462 NVCPA 4466

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EGFLAMNP_001192230.1 FN3 36..133 CDD:238020 31/146 (21%)
FN3 142..234 CDD:238020 16/104 (15%)
LamG 391..541 CDD:238058 52/154 (34%)
EGF_CA 560..602 CDD:238011 11/42 (26%)
LamG 618..765 CDD:238058 43/155 (28%)
EGF_CA <792..820 CDD:238011 13/27 (48%)
Laminin_G_2 868..993 CDD:280389 36/129 (28%)
trolNP_001027038.3 LDLa 447..480 CDD:238060
LDLa 532..564 CDD:238060
LDLa 571..606 CDD:238060
LDLa 616..650 CDD:238060
LDLa 704..739 CDD:238060
LDLa 813..847 CDD:238060
LDLa 852..887 CDD:238060
LDLa 902..936 CDD:238060
LDLa 956..990 CDD:238060
LDLa 997..1030 CDD:238060
LDLa 1033..1067 CDD:238060
LDLa 1072..1105 CDD:238060
LDLa 1133..1165 CDD:238060
LDLa 1182..1215 CDD:238060
LDLa 1221..1251 CDD:238060
LDLa 1252..1286 CDD:238060
LDLa 1292..1326 CDD:238060
IG 1344..1421 CDD:214652
Ig 1344..1405 CDD:299845
LDLa 1439..1473 CDD:238060
LDLa 1479..1513 CDD:238060
LDLa 1522..1556 CDD:238060
IG_like 1566..1649 CDD:214653
Ig_Perlecan_D2_like 1574..1649 CDD:143220
Laminin_B 1748..1864 CDD:278481
EGF_Lam 1935..1989 CDD:238012
Laminin_B 2113..2238 CDD:278481
EGF_Lam <2250..2276 CDD:238012
EGF_Lam 2284..2333 CDD:238012
Laminin_EGF <2369..2399 CDD:278482
Laminin_B 2465..2587 CDD:278481
I-set 2686..2772 CDD:254352
Ig_2 2689..2771 CDD:290606
Ig 2779..2865 CDD:299845
IG_like 2798..2864 CDD:214653
Ig 2882..2965 CDD:299845
IG_like 2882..2950 CDD:214653
Ig 2977..3061 CDD:299845
IG_like 2984..3058 CDD:214653
IG_like 3074..3152 CDD:214653
Ig 3086..3153 CDD:299845
I-set 3155..3243 CDD:254352
IGc2 3171..3233 CDD:197706
IG 3371..3447 CDD:214652 20/84 (24%)
IGc2 3377..3437 CDD:197706 13/61 (21%)
Ig 3456..3534 CDD:299845 23/128 (18%)
IG 3465..>3526 CDD:214652 20/94 (21%)
Ig 3603..3665 CDD:299845 17/76 (22%)
IG 3610..3683 CDD:214652 20/87 (23%)
IG 3696..3762 CDD:214652 15/78 (19%)
Ig 3704..3771 CDD:299845 13/79 (16%)
LamG 3784..3929 CDD:238058 51/147 (35%)
EGF 3952..3984 CDD:278437 9/31 (29%)
LamG 4032..4185 CDD:238058 43/160 (27%)
Laminin_G_2 4315..4444 CDD:280389 36/130 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D17288at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

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