Protein Alignment EGFLAM and SP2353

DIOPT Version :10

• Sequence 1: NP_001192230.1
• Gene: EGFLAM / 133584
• HGNCID: 26810
• Length: 1017
• Species: Homo sapiens
• Sequence 2: NP_611082.2
• Gene: SP2353 / 36771
• FlyBaseID: FBgn0034070
• Length: 1361
• Species: Drosophila melanogaster
• Alignment Length: 1140
• Identity: 277/1140 - (24%)
• Similarity: 422/1140 - (37%)
• Gaps: 385/1140 - (33%)

Human   225 SPRSWPSDIIRTLCPEEAGSGRYGPRYITDMGAGEDDEGFEDDLDL-----DISFEEVKPLPATK 284
            ||...|...:.....|..||..|...|.:||...:|..  .:.|:|     ..::::.......|
  Fly   252 SPTRAPKQRVDVDYGEGDGSDDYSYSYKSDMSVYDDVN--NNQLNLRRNSKSQTYQQTSNTNTAK 314

Human   285 GGNKKFLVESKKMSISNPKTISRLIPPTSASLPVTTVAPQPIPIQRKGKNGVAIMSRLFDMPCDE 349
            ...|...|.|.|:.:...:..:|| ...||:.|...              |.|:.:......|:.
  Fly   315 NRRKYPNVTSNKVQMHITRETNRL-ENISAAEPAVV--------------GAAMTTDRSTPTCNL 364

Human   350 TLCSADSFCVNDYTWGGSRCQCTLGKGGESCSEDIVIQYPQFFGHSYVTFEPLKNSYQAFQITLE 414
            . |.:|..|..:.|...|||.|..||.|..|.|||....|:|...|::.|..|..:|:..|:.:|
  Fly   365 D-CGSDGICALEATAASSRCLCPFGKTGNGCQEDIRAHVPRFAKRSWLAFPALHGAYKHVQLRIE 428

Human   415 FRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSETKIKLGGWHTVMLYRD 479
            ||.|:.||::|..||.:...||||:|.:.:..::|.|:||:||..:.|...|.|..|::|::||.
  Fly   429 FRPESFDGIILLSGERDDLTGDFMALLLNKGFVEFWFDCGSGVGSVRSRETILLNEWNSVIIYRH 493

Human   480 GLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRR 544
            ..:..|.||:||.|.|:|.|.:|:||||.|::|||..:...|.:......||.||::....|...
  Fly   494 RWDAWLVLNHGTKVQGRSNGLFSRITFREPVFLGGIGNITGLAKRLPLAEGFAGCIRRFVANEHD 558

Human   545 IDMRPWPLGKALSGADVGECSSGICDEASCIHGGTCTAIKAD-SYICLCPLGFKGRHCEDAFTLT 608
            ......|||..::|.|:.:||:..|....|.|||.|  :.:| ..|||||:||.|..||....|.
  Fly   559 YKFTEHPLGDVINGFDIQDCSTDKCVRYPCQHGGKC--LPSDQGAICLCPIGFVGDLCEIRMDLQ 621

Human   609 IPQFR-ESLRSYAATPWPLEPQHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVE 672
            :|.|. .|...||    || ....|.::|.::|.:|:..||::|||......||:::.|..|.||
  Fly   622 VPAFNGSSFLRYA----PL-GDSALIWLELKVTLKPEQADGLILYSGPEHRGDFIALYLNDGFVE 681

Human   673 FRFDCGSGTGVLRSEDPLTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIG 737
            |.||.|||..::|||..|:||.||.:::||||:..:|:|||.:.|..::..||..:..:.::|:|
  Fly   682 FAFDLGSGPALVRSEHSLSLGQWHTIKISRTARLAVLKVDKHQEVLTISSNGFWHLSLDQNLFVG 746

Human   738 GVPNYD----DVKKNSGVLKP-FSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPCVRAPCAHGG 797
            ||.:.|    |:|     .|| |.|.||:|.:|..::.:..:...|.|:.|..|.||..||....
  Fly   747 GVNHVDRLPLDLK-----YKPFFVGCIQRIDINGHSLGIVAEALGGSNIGNCPHACVARPCGPLA 806

Human   798 SCRPRKEGYDCDC---------------------------------------------------- 810
            .|.|:.|.|:|.|
  Fly   807 ECVPQMESYECRCSIHNERCNKAAEVPPEQLPELALHKSKVLETKDNGEAAKKVSGLAHKKHSKK 871

Human   811 ----------------------------------------------------------------- 810
                                                                             
  Fly   872 HRNLHKPTPATSTTTSTTSTTTTTTEAPSERTEEATAGALSNEEIEDDIIFRLVQQQQQQKELKK 936

Human   811 ----------------------------------------------------------------- 810
                                                                             
  Fly   937 QHQQTTTTAPATSTTSSGPSKAKPRLSGKHHASKHEHHLKPNAAFTRKLSRLPTHYESFQTNPDS 1001

Human   811 -----------------------------PLGFE------------------------------- 815
                                         ||.||
  Fly  1002 DILTFEDNNDWVTSLQQQEYGDAMAASQVPLAFEDASPGTPRSSDNNEDDENAFVFDESLFDASD 1066

Human   816 ---------------------GLHC-------------QKECG---------------NYCLNTI 831
                                 ..|.             .:|.|               :..|..:
  Fly  1067 GTEEYQRKQLAQDMKRIMSNSNAHSSHKKAEVQFPPQGSQEVGTANEDTSQYSDDYNDDELLTPV 1131

Human   832 IEAIE----------IPQ-------------------------------FIGR-SYLTYDNPDIL 854
            ::..|          .||                               |.|. ||..|::.|.:
  Fly  1132 MQGGEEVKLEQHTSSTPQTHTDWSLLKKFDLSAEHQSQVQGVRKNFGACFAGSDSYFHYNDADTM 1196

Human   855 KRVSGSRSNVFMRFKTTAKDGLLLWRG-DSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNG 918
            .:|.....::.:|.||.:::|::||.| ......:.|::|||:..|.|.|.|:||||...|..||
  Fly  1197 SQVISYSIDLNLRIKTHSENGVILWTGRQGTTEEHDDYLSLGIEQGYLHFRYDLGSGEVDIRFNG 1261

Human   919 S-FNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMR 982
            : .:||.||||:|:|:.|.|.:.||.....|.::||.:||||.:..||||||.::...|:::|..
  Fly  1262 TKVSDGLWHRVRAIRNSQEGYLEVDGRKTVTLRAPGKLRQLNTDTGLYVGGMPDVGYFTHQRYFS 1326

Human   983 GLVGCISHFTLSTDYHISLVEDAVDGKNINTCGAK 1017
            |:|||||...|:.:..::.        :.||.|.:
  Fly  1327 GIVGCISEIVLAGEMKLNF--------DPNTLGTE 1353

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EGFLAM	NP_001192230.1	FN3	36..133	CDD:238020
		FN3	142..234	CDD:238020	3/8 (38%)
		LamG	391..541	CDD:238058	56/149 (38%)
		EGF_CA	560..602	CDD:238011	18/42 (43%)
		LamG	618..765	CDD:238058	58/151 (38%)
		EGF_CA	<792..820	CDD:238011	13/303 (4%)
		Laminin_G_2	868..993	CDD:460494	54/126 (43%)
SP2353	NP_611082.2	FXa_inhibition	53..82	CDD:464251
		LamG	404..555	CDD:238058	56/150 (37%)
		EGF	583..612	CDD:394967	14/30 (47%)
		LamG	625..774	CDD:238058	60/158 (38%)
		LamG	1205..1340	CDD:214598	56/134 (42%)