Protein Alignment EGFLAM and Nrg

DIOPT Version :10

• Sequence 1: NP_001192230.1
• Gene: EGFLAM / 133584
• HGNCID: 26810
• Length: 1017
• Species: Homo sapiens
• Sequence 2: NP_001245581.1
• Gene: Nrg / 31792
• FlyBaseID: FBgn0264975
• Length: 1309
• Species: Drosophila melanogaster
• Alignment Length: 400
• Identity: 89/400 - (22%)
• Similarity: 146/400 - (36%)
• Gaps: 112/400 - (28%)

Human    46 LNCTAFSIQWKMPRHPGSPILGYTVFYSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEY 110
            |..:||.:.||.|.:|...:.||.::|.|| .:..:.|:....|...|...|...:..|||.::|
  Fly   928 LGSSAFMLHWKKPLYPNGKLTGYKIYYEEV-KESYVGERREYDPHITDPRVTRMKMAGLKPNSKY 991

Human   111 RVSIAAYSQAGKGRLSSPRHV--TTLSQDSCLPPAAPQQPHVIVVSDSEVA---LSWKPGASEGS 170
            |:||.|.::.|:|   |..::  |||.....:.||.|......:.||:.:|   ::|.| ::||.
  Fly   992 RISITATTKMGEG---SEHYIEKTTLKDAVNVAPATPSFSWEQLPSDNGLAKFRINWLP-STEGH 1052

Human   171 APIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGLDPDTNYQFAVRAMNSH------------- 222
            ....::::..|:.  :.:|...:|....|...:.||||:|.|:|.|.:::.|
  Fly  1053 PGTHFFTMHRIKG--ETQWIRENEEKNSDYQEVGGLDPETAYEFRVVSVDGHFNTESATQEIDTN 1115

Human   223 ---GP--------SPRSWPSDIIRTLC----------------------------------PEEA 242
               ||        :...|...::..|.                                  |||.
  Fly  1116 TVEGPIMVANETVANAGWFIGMMLALAFIIILFIIICIIRRNRGGKYDVHDRELANGRRDYPEEG 1180

Human   243 GSGRYGPRYITDMGAGE------DDEGFEDDLDLDISFEEVKPLPATKGGNKKFLVESKKMSI-- 299
            |...|. :.:.:..||.      :..|.|.|.|....:.:.....||..........||..|:
  Fly  1181 GFHEYS-QPLDNKSAGRQSVSSANKPGVESDTDSMAEYGDGDTAVATAAARAAAAARSKLTSLPT 1244

Human   300 ----------------SNPKTISRLIPPTSAS-LPVTTVA-PQPIPIQRKGKNGVAIMSRLFDMP 346
                            ..|::       |||| :|:.::| |.|.|.........|        |
  Fly  1245 STQQQQQQQQQQQQQQEQPQS-------TSASTVPLISLASPSPSPSSTSNSPTAA--------P 1294

Human   347 CDETLCSADS 356
            ....||.||:
  Fly  1295 PSYELCVADA 1304

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EGFLAM	NP_001192230.1	FN3	36..133	CDD:238020	27/88 (31%)
		FN3	142..234	CDD:238020	26/118 (22%)
		LamG	391..541	CDD:238058
		EGF_CA	560..602	CDD:238011
		LamG	618..765	CDD:238058
		EGF_CA	<792..820	CDD:238011
		Laminin_G_2	868..993	CDD:460494
Nrg	NP_001245581.1	Ig	29..128	CDD:472250
		Ig strand B	55..59	CDD:409353
		Ig strand C	68..72	CDD:409353
		Ig strand E	94..98	CDD:409353
		Ig strand F	108..113	CDD:409353
		Ig strand G	122..125	CDD:409353
		Ig	137..216	CDD:472250
		Ig strand B	151..155	CDD:409353
		Ig strand C	165..169	CDD:409353
		Ig strand E	192..196	CDD:409353
		Ig strand F	209..214	CDD:409353
		ig	251..332	CDD:395002
		Ig strand B	264..268	CDD:409353
		Ig strand C	277..281	CDD:409353
		Ig strand E	305..309	CDD:409353
		Ig strand F	314..319	CDD:409353
		Ig strand G	328..331	CDD:409353
		IgI_4_hemolin-like	339..427	CDD:409570
		Ig strand A	339..342	CDD:409570
		Ig strand A'	348..351	CDD:409570
		Ig strand B	356..363	CDD:409570
		Ig strand C	369..374	CDD:409570
		Ig strand C'	377..379	CDD:409570
		Ig strand D	387..391	CDD:409570
		Ig strand E	393..397	CDD:409570
		Ig strand F	406..414	CDD:409570
		Ig strand G	417..427	CDD:409570
		Ig	446..517	CDD:472250
		Ig strand B	449..453	CDD:409358
		Ig strand C	462..466	CDD:409358
		Ig strand E	483..487	CDD:409358
		Ig strand F	497..502	CDD:409358
		Ig strand G	510..513	CDD:409358
		Ig	521..615	CDD:472250
		Ig strand B	538..542	CDD:409353
		Ig strand C	553..557	CDD:409353
		Ig strand E	577..581	CDD:409353
		Ig strand F	591..596	CDD:409353
		Ig strand G	604..607	CDD:409353
		FN3	613..707	CDD:238020
		FN3	683..>1051	CDD:442628	38/127 (30%)
		fn3	817..905	CDD:394996
		fn3	918..1007	CDD:394996	27/82 (33%)
		FN3	1041..1111	CDD:238020	17/72 (24%)
		Bravo_FIGEY	1155..>1221	CDD:464016	11/66 (17%)