DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment EGFLAM and T19D12.6

DIOPT Version :9

Sequence 1:	NP_001192230.1	Gene:	EGFLAM / 133584	HGNCID:	26810	Length:	1017	Species:	Homo sapiens
Sequence 2:	NP_495350.4	Gene:	T19D12.6 / 174097	WormBaseID:	WBGene00020581	Length:	779	Species:	Caenorhabditis elegans

Alignment Length:	816	Identity:	190/816 - (23%)
Similarity:	311/816 - (38%)	Gaps:	190/816 - (23%)

- Green bases have known domain annotations that are detailed below.

Human   336 VAIMSRLFDMPC--DETLCSADSFCVNDYTWGGSRCQC----TLGKGGESCSEDIVIQYPQ---- 390
            :|..:.:|...|  :..||......::..|:   .|.|    .|...|.||..|..:||.:
Worm    15 IAGSTNVFQGSCAAEHVLCEQLCEALSPETY---ECSCWEGHVLQDDGLSCRVDTDVQYSEEKKE 76

Human   391 -----------------------------------FFGHSYVTFEPLKNSYQAFQITLEFRA-EA 419
                                               |.|.:|..|....::|....||::|:. |.
Worm    77 ITKKRTRKLETSTFPIRKLTIENKKKITNSPKPLAFKGSNYAEFAIKDDTYLETNITIQFKLDEH 141

Human   420 EDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSETKIKLGGWHTVMLYR------ 478
            :||::.:.||..  ..||:|:.:...::..|.:||.|....:...|..:|.||.:.::|
Worm   142 KDGIIFFAGELM--GDDFLSITLDGPNVIMRHDCGEGTIEDMYHGKFAIGEWHEINVWRKNCDLT 204

Human   479 ----DGLNGLL----QLNNGTPVTGQSQGQYSKITFRTPLYLGGAP-SAYWLVRATGTNRGFQGC 534
                ||.:.|:    :..|           |..||....::||.|| :..:|.:.||...||:||
Worm   205 EIIVDGGHKLVDHADEFKN-----------YKGITMDEGVFLGAAPHNIEFLQQKTGAFEGFRGC 258

Human   535 VQSLAVNGRRIDMRPWPLGKALSGADVGECSSGICDEASCIHGGTCTAIKADSYICLCPLGFKGR 599
            |:.|.|||..:......:.|||..:....|.    :|...:.       |....|.....|.|..
Worm   259 VRLLVVNGEVLLNTNETINKALDSSVNYYCG----EEEPKLE-------KKKRKIIKVMTGDKEN 312

Human   600 HCEDA--------FTLT---IPQFRES----LRSYAATPWPL----------------------- 626
            ..|::        |.||   ||:..|:    :.:.:.|..||
Worm   313 DNEESDDIIQIEMFDLTQRGIPKILETPGMHMSTQSPTSLPLGHPILKEIIVQQEHVTTTPAPSS 377

Human   627 -----------------------EPQHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAG 668
                                   .|...||::|..|.|:.:...|||.: :...|| ||.:.:..
Worm   378 TSTKSSITWKVAHFNGNSNVIVPAPDSILSYLELSIQFKTEKPSGVLFF-WKEDSK-FLIVTVEN 440

Human   669 GHVEFRFDCGSGTGVLRSEDPLTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNT- 732
            ..::.....|....:||||:.::|.:||:|.|.|:.|..:|:|:||..||........:|...|
Worm   441 SFIKVYASLGVDATILRSENAVSLYHWHKLEVWRSGKGVLLKVNKQGWVESELHASKLEIIEETG 505

Human   733 DIFIGGVPNYD--DVKKNSGVLKPFSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPCVRAPCAH 795
            :||||.:.:.|  .|.|:   ::.|:|.:::|.||.:.|.::..:.:.|.      .|.:.||:.
Worm   506 NIFIGSLDDNDIPSVVKD---IEGFAGCVKRIRLNGKAILMQSTYATNVT------ECFQDPCST 561

Human   796 GG---SCRPRKEGYDCDC--PLGFEGLHCQKECGNYCLNTIIEAIEIPQFIGRSYLTYDNPDILK 855
            .|   .|........|.|  |:.          |..|..|....|...:|.|.|||..||..::.
Worm   562 FGCPNKCLAHNSMPVCQCEWPMS----------GRKCSVTSESEISAMKFSGLSYLELDNEAVMS 616

Human   856 RVSGSRSNVFMRFK----TTAKDGLLLWRGDSPMRPNSDFISLGLRDGALV-FSYNLGSGVASIM 915
            .::|...::.:.||    |.....:::..||  :....||..|.:.....| |:.|||||...:.
Worm   617 HITGDSLDMAVNFKIQNTTQTVRQIVISAGD--ITHEDDFFELSIDTNRFVRFALNLGSGTIVLT 679

Human   916 VNGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQY 980
            ......|.||..|:.:|.....|::|:.....||.:|....|||:...:::|.........:.:.
Worm   680 HPKRIEDERWITVEVIRKRNLVKLSVNGEDPITGFAPEGAEQLNVYRNIFIGNNFTPDGSPDGRD 744

Human   981 MRGLVGCI--SHFTLSTDYHISLVEDAVDGKNINTC 1014
            ..||.|||  ..|..:|..|....:.|:   ||..|
Worm   745 FTGLDGCIISLRFDQTTISHPKQAKTAI---NIQDC 777

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EGFLAM	NP_001192230.1	FN3	36..133	CDD:238020
		FN3	142..234	CDD:238020
		LamG	391..541	CDD:238058	45/165 (27%)
		EGF_CA	560..602	CDD:238011	6/41 (15%)
		LamG	618..765	CDD:238058	46/195 (24%)
		EGF_CA	<792..820	CDD:238011	7/32 (22%)
		Laminin_G_2	868..993	CDD:280389	35/131 (27%)
T19D12.6	NP_495350.4	FXa_inhibition	26..62	CDD:291342	8/38 (21%)
		LamG	109..265	CDD:238058	45/168 (27%)
		LamG	388..537	CDD:238058	43/153 (28%)
		LamG	601..758	CDD:238058	42/158 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3509
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H65044
Inparanoid	1	1.050	183	1.000	Inparanoid score	I3016
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D17288at33208
OrthoFinder	1	1.000	-	-		FOG0007196
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_107971
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4884
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.800