DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dgcr2 and Lrp4

DIOPT Version :9

Sequence 1:NP_034178.2 Gene:Dgcr2 / 13356 MGIID:892866 Length:549 Species:Mus musculus
Sequence 2:NP_727914.1 Gene:Lrp4 / 32552 FlyBaseID:FBgn0030706 Length:2009 Species:Drosophila melanogaster


Alignment Length:419 Identity:84/419 - (20%)
Similarity:128/419 - (30%) Gaps:136/419 - (32%)


- Green bases have known domain annotations that are detailed below.


Mouse    30 CNPGQFACHGGTIQCIPLPWQCDGWPTCEDKSDEADCPEVTGEARPYGKETVDLRQGRARGGDPT 94
            |....|.|:.|  .||.|.::|||...|.|.|||..|..|.... |.|:  ...|.|....|.|:
  Fly   306 CTDEHFTCNDG--YCISLAFRCDGEHDCNDNSDELKCAAVINSC-PEGE--FKCRGGLGGAGGPS 365

Mouse    95 HFHTVNVAQPVRFSSFLGKCPSGWHHYEGTASCYRVYLSGENYWDAAQTCQRVNGSLATFSTDQE 159
                             |:|.......:|...|      |:  |...:.|.:    ..:..|..|
  Fly   366 -----------------GQCILNRFRCDGDNDC------GD--WSDEENCPQ----KPSLCTSNE 401

Mouse   160 LRFV----LAQEW--DQPERSFGWKDQRKLW-VGYQYVITGRNHSL---EGR-----WEVAFKGS 209
            .:..    :.:.|  |:.:...|.:|:.... :|.::.:|..:...   .||     |  ...|.
  Fly   402 YKCADGTCIPKRWKCDKEQDCDGGEDENDCGSLGSEHPLTCGSDEFTCNNGRCILKTW--LCDGY 464

Mouse   210 PEVFLPPDPIFASAMSENDNVFCAQLQCFHFPTLRHHDLHSWHAESCSEKSSFLCKRSQTCVDIK 274
            |:           ..:..|.|.| .|||         ||           ..|||...|...::|
  Fly   465 PD-----------CAAGEDEVEC-HLQC---------DL-----------GQFLCPTKQNLTNLK 497

Mouse   275 DNV----VDEGFYFTPKGDDPCLSCTCHR--GEPEMCVAALCERPQGCQQYRKDPKECC------ 327
            ..|    :.:|....|.|:|.. .|...|  .||..|       .|.|.:......||.      
  Fly   498 ICVHQKHICDGHNECPAGEDEA-DCPKERKCSEPSPC-------EQLCIETTAGSNECACRLGYV 554

Mouse   328 ----KFMCLDPDGSSLFDSMASGMR-------LVVSCISSFLIL-----------SLLLFMVHRL 370
                |..|.|.|......|.....:       ...||.:.:::.           ::.|.:.:|.
  Fly   555 MDKNKVNCTDIDECQYLTSPVCSQKCHNTMGSFKCSCETGYILRPDLRSCKALGGAMTLLVANRW 619

Mouse   371 RQRR-----------RERIESLIGANLHH 388
            ..||           .:.:.:.|..:.||
  Fly   620 DIRRVTLSNNRYSAIVKGLHNAIALDFHH 648

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dgcr2NP_034178.2 LDLa 30..66 CDD:238060 15/35 (43%)
CLECT_DGCR2_like 114..266 CDD:153069 30/166 (18%)
VWC 270..328 CDD:214564 15/73 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 416..549
Lrp4NP_727914.1 LDLa 267..301 CDD:238060
LDLa 306..340 CDD:238060 15/35 (43%)
LDLa 347..390 CDD:238060 12/70 (17%)
LDLa 397..431 CDD:238060 6/33 (18%)
LDLa 442..476 CDD:238060 7/46 (15%)
LDLa 480..521 CDD:238060 13/61 (21%)
FXa_inhibition 576..604 CDD:291342 2/27 (7%)
LY 634..671 CDD:214531 3/15 (20%)
NHL <656..793 CDD:302697
LY 680..714 CDD:214531
NHL repeat 681..722 CDD:271320
NHL repeat 726..760 CDD:271320
LY 761..803 CDD:214531
NHL repeat 769..793 CDD:271320
FXa_inhibition 882..912 CDD:291342
LY 946..985 CDD:214531
NHL <967..1142 CDD:302697
LY 988..1030 CDD:214531
NHL repeat 998..1037 CDD:271320
NHL repeat 1038..1080 CDD:271320
NHL repeat 1084..1119 CDD:271320
FXa_inhibition 1185..1220 CDD:291342
NHL 1260..>1445 CDD:302697
NHL repeat 1260..1296 CDD:271320
NHL repeat 1302..1337 CDD:271320
NHL repeat 1345..1383 CDD:271320
FXa_inhibition <1499..1525 CDD:291342
LY 1600..1640 CDD:214531
LY 1643..1686 CDD:214531
LY 1688..1729 CDD:214531
FXa_inhibition 1801..>1825 CDD:291342
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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