DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Twist2 and twi

DIOPT Version :9

Sequence 1:	NP_031881.1	Gene:	Twist2 / 13345	MGIID:	104685	Length:	160	Species:	Mus musculus
Sequence 2:	NP_001033967.1	Gene:	twi / 37655	FlyBaseID:	FBgn0003900	Length:	490	Species:	Drosophila melanogaster

Alignment Length:	213	Identity:	74/213 - (34%)
Similarity:	98/213 - (46%)	Gaps:	67/213 - (31%)

- Green bases have known domain annotations that are detailed below.

Mouse    11 PVDSL-GTSEEELERQPKRFGRKRRYSKKS------------SEDGSP---------------TP 47
            |.:|| |::....:|....:.|....|..|            ::|||.               .|
  Fly   279 PANSLNGSAYSSSDRDDMEYARHNALSSVSDLNGGVMSPACLADDGSAGSLLDGSDAGGKAFRKP 343

Mouse    48 GKRGKKGSPSAQSFEELQSQRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAAR 112
            .:|.|:.....:..:|..:||::|||||||||||||:||.:|::|||||||||||||||||||.|
  Fly   344 RRRLKRKPSKTEETDEFSNQRVMANVRERQRTQSLNDAFKSLQQIIPTLPSDKLSKIQTLKLATR 408

Mouse   113 YIDFLYQVLQSDEMD-----------------------------------NKMTSCSYVAHERLS 142
            |||||.::|.|.::.                                   .|......:..|:||
  Fly   409 YIDFLCRMLSSSDISLLKALEAQGSPSAYGSASSLLSAAANGAEADLKCLRKANGAPIIPPEKLS 473

Mouse   143 YAFSVWRMEGAWSMSASH 160
            |.|.||||||    .|.|
  Fly   474 YLFGVWRMEG----DAQH 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Twist2	NP_031881.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..63		14/79 (18%)
Twist2	NP_031881.1	bHLH_TS_TWIST2	51..132	CDD:381543	48/115 (42%)
twi	NP_001033967.1	HLH	363..413	CDD:278439	41/49 (84%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839669
Domainoid	1	1.000	90	1.000	Domainoid score	I7765
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001055
OrthoInspector	1	1.000	-	-		otm43384
orthoMCL	1	0.900	-	-		OOG6_107717
Panther	1	1.100	-	-	LDO	PTHR23349
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5507
SonicParanoid	1	1.000	-	-		X1477
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.870