Protein Alignment CPEB2 and orb

DIOPT Version :10

• Sequence 1: XP_005248192.2
• Gene: CPEB2 / 132864
• HGNCID: 21745
• Length: 1037
• Species: Homo sapiens
• Sequence 2: NP_524460.2
• Gene: orb / 42752
• FlyBaseID: FBgn0004882
• Length: 915
• Species: Drosophila melanogaster
• Alignment Length: 952
• Identity: 246/952 - (25%)
• Similarity: 348/952 - (36%)
• Gaps: 311/952 - (32%)

Human   218 LLQ----PAQLAQRQQQQPPQQFSLLHQQHLSPQDFAPR----------QRPADLPPLPQLPPSP 268
            |||    .:.|....|||..||..|..|||........|          ..|..|..|..|   .
  Fly    30 LLQKHSISSYLDHHHQQQQQQQHHLQLQQHQQQHSLLERCNDDGLISFINDPITLNDLLGL---C 91

Human   269 PAAPRRRHGGAGSPRKTPA----AGEGSAAESPNAGLASSTPVNPAPGSMESPNHPLLNSPSNLL 329
            .|:......|.|....|.|    ||.|..|....||.|::|.|
  Fly    92 GASTANEVVGTGQTPSTSAPILGAGGGGRANGVTAGAATATGV---------------------- 134

Human   330 PGGALGAGAFSSLQSPDLPHPGGGGGGG-------------GGGPPGGGGGGGSASP-------- 373
                 |.||..:|..|.:|...||||||             ...|....||.||:|.
  Fly   135 -----GVGAGGTLPGPGVPSIQGGGGGGVVGQQTNASCNTSAANPSASFGGNGSSSDVNNLLLAS 194

Human   374 ----------------------PPLPGFGTPWSVQTASPP-----------PQPQQPPPTQPQQQ 405
                                  .||    ||.|..:::.|           ....|..|.:..|:
  Fly   195 AAAAAAAAAGDGAQLSANAAAYAPL----TPSSTHSSASPGTKSNFDYFQFENVAQSNPLKAFQR 255

Human   406 P------PPPQQPPQP--------QPQPPGSSATTPGGGSGGSLSAMPPPSPDSENGFYPGLPSS 456
            .      ..|..|..|        ...|..|.::....|.|.|:        ||.|.||......
  Fly   256 TNISFDCSAPLSPSTPTSIYNRSFHSSPLVSDSSNSSSGIGLSM--------DSINMFYNQQQQQ 312

Human   457 MNPAFFPSFSPVSPHGCTGLSVPTSGGGGGGFGGPFSATAVPPPPPPAMN--------------- 506
            ..|         ...|.|.|    ....|.|.|...:..:.....|.:.|
  Fly   313 QQP---------EQQGYTSL----GNSMGSGLGLSLANASTRSNSPESQNSSNSTTEQNLLDMIN 364

Human   507 --------IP--QQQPPPPAAPQQPQSRRSPVSPQLQQQHQAAAAAFLQQR---NSYNHHQPLLK 558
                    ||  |||.......||.|.:::....|:|||||      |||:   .:.|:.|.:
  Fly   365 LLSVNSNKIPHQQQQQQQQQQQQQQQQQQNQQQLQVQQQHQ------LQQQFVNLNRNYEQQI-- 421

Human   559 QSPWSNHQSSGWGTGSMSWGAMHGRDHRRTGNMGIPGTMNQISPLKKPFSGNVIAPPKFTRSTPS 623
                    |:..|:      ..||.:|...| :|...            |||
  Fly   422 --------SANLGS------QQHGFEHNGVG-VGASS------------SGN------------- 446

Human   624 LTPKSWIEDNVFRTDNNSNTLLPLQVRMVRSSLQLPAWGSDSLQDSWCTAAGTSRIDQDRSRMYD 688
                    :|.|...|..|                                 .:.:|.:.:::.:
  Fly   447 --------ENCFSQYNLEN---------------------------------ITSVDMELAKLQN 470

Human   689 SLNMHSLENSLIDIMRAEHDPLKGRLSYPHPGT----------DNLLMLNARSYGRRRGRSSLFP 743
            ...:::|:  |:. .:|:..||..:|...:.|.          .||:         ..|.|||..
  Fly   471 LQRINTLK--LLH-AQAQQMPLINQLLQSYAGNAIGSVGGSNLGNLM---------SAGGSSLMT 523

Human   744 IDDG------LLDDGHSDQV-------GVLNSPTC-YSAH--QNGERIERFSRKVFVGGLPPDID 792
            ...|      ..:|||.|:|       ..|...|| :|.|  ....|:..:|.|||:||:|.||.
  Fly   524 EMAGNVGGIITTNDGHLDRVAKFYKSSAALCDATCTWSGHLPPRSHRMLNYSPKVFLGGIPWDIS 588

Human   793 EDEITASFRRFGPLVVDWPHKAESKSYFPPKGYAFLLFQEESSVQALIDACI-----EEDGKLYL 852
            |..:...|:.||.:.|:||.|.:..:  .||||.:::|:.:..|:||:.||:     ...|:.|.
  Fly   589 EQSLIQIFKPFGSIKVEWPGKEQQAA--QPKGYVYIIFESDKQVKALLSACVLQVDDSHCGRNYF 651

Human   853 C-VSSPTIKDKPVQIRPWNLSDSDFVMDGSQPLDPRKTIFVGGVPRPLRAVELAMIMDRLYGGVC 916
            . :||..||.|.|::.||.::||:||...||.|||.||:|||.:...|.|..|..|||.|:.||.
  Fly   652 FKISSRRIKSKDVEVIPWIIADSNFVRSSSQKLDPTKTVFVGALHGKLTAEGLGNIMDDLFDGVL 716

Human   917 YAGIDTDPELKYPKGAGRVAFSNQQSYIAAISARFVQLQHGDIDKRVEVKPYVLDDQMCDECQGA 981
            ||||||| :.|||.|:|||.|||.:||:.|:||.|::::.....|:|:|.|| |:|.:|     :
  Fly   717 YAGIDTD-KYKYPIGSGRVTFSNFRSYMKAVSAAFIEIRTTKFTKKVQVDPY-LEDALC-----S 774

Human   982 RCGGKFAPFFCANVTCLQYYCEFCWANIHSRAGREFHKPLVK 1023
            .||.:..|::|..::|.:|:|..||...||....:.||||.:
  Fly   775 ICGVQHGPYYCRELSCFRYFCRSCWQWQHSCDIVKNHKPLTR 816

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CPEB2	XP_005248192.2	RRM1_CPEB2_like	780..871	CDD:410123	36/96 (38%)
		RRM2_CPEB2_like	888..968	CDD:410125	40/79 (51%)
		CEBP_ZZ	963..1024	CDD:465105	22/61 (36%)
orb	NP_524460.2	RRM1_CPEB1	574..674	CDD:410122	37/101 (37%)
		RRM2_CPEB1	685..768	CDD:410124	44/84 (52%)
		CEBP_ZZ	762..817	CDD:465105	22/61 (36%)