DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CPEB2 and cpeb2

DIOPT Version :9

Sequence 1:	XP_005248192.2	Gene:	CPEB2 / 132864	HGNCID:	21745	Length:	1037	Species:	Homo sapiens
Sequence 2:	XP_004911287.2	Gene:	cpeb2 / 100492019	XenbaseID:	XB-GENE-961735	Length:	815	Species:	Xenopus tropicalis

Alignment Length:	1059	Identity:	619/1059 - (58%)
Similarity:	671/1059 - (63%)	Gaps:	266/1059 - (25%)

- Green bases have known domain annotations that are detailed below.

Human     1 MRDFGFGVLQTAPLRSSS---------PGPLFCGEAYGPYAVGSVNPLPSATPFGPLSPPPLPVT 56
            |.|:|||:||.|.|.|.|         .|.||.|.||
Frog     1 MGDYGFGLLQAANLSSGSGGSGGSGGGGGSLFGGGAY---------------------------- 37

Human    57 GFLEAASPFSVPLGGGAGSPA-AAASSSSPFLA--HQQTMQDELLLGLTQQPARPLSGAAATEKL 118
                         .|.|..|: :|||.|:.||:  :||.||||||||::..|....|.||.:
Frog    38 -------------RGSAQFPSLSAASGSALFLSAGYQQVMQDELLLGVSCAPGSKHSIAAKS--- 86

Human   119 PDHHPGGGTIAGVTHLLPSQDFKPSLHHPSSSSASSCCCCRTSSPQDFSKRQQQQLSSQKRKEFS 183
                                       .||.:|..:......:..:|||.::......:.:|
Frog    87 ---------------------------GPSRASPPALLLQEPAKRKDFSPQEGDAFREELKK--- 121

Human   184 PPHLPHPPDSKPPPPPPPLHCPGRFSPPPPPAGPLLQPAQLAQRQQQQPPQQFSLLHQQHLSPQD 248
                                                ||.::    .|||.     .:|:..||..
Frog   122 ------------------------------------QPGEM----NQQPS-----AYQRQGSPAA 141

Human   249 FAPRQRPADLPPLPQLPPSPPAAPRRRHGGAGSPRKTPAAGEGSAAESPNAGLASSTPVNPAPGS 313
            .|..:. .|.|. ..||.||.::.......:....:....||..||.||.   |.|....||.|.
Frog   142 AAAAEE-LDCPD-KNLPGSPSSSSSSSSSSSSCSAEEAVLGEAHAATSPP---ALSHHHLPAKGK 201

Human   314 --MES-----PNHPLLNSPSNLLPGGALGAGAFSSLQSPDLPH---PGGGGGGGGGGPPGGGGGG 368
              ||:     ||  ||..|   .||            ||:||.   |||
Frog   202 LPMEAQGGHLPN--LLGGP---YPG------------SPELPSTQTPGG---------------- 233

Human   369 GSASPPPLPGFGTPWSVQTASPPPQPQQPPPTQPQQQPPPPQQPPQPQPQPPGSSATTPGGGSGG 433
               |||.||||||||||||:||||    |||..|||     |||..|.|             :|.
Frog   234 ---SPPALPGFGTPWSVQTSSPPP----PPPALPQQ-----QQPATPHP-------------AGP 273

Human   434 SLSAMPPPSPDSENGFYPGLPSSMNPAFFPSFSPVSPHGCTGLSVPTSGGGGGGFGGPFSATAVP 498
            :|:|:..|.|||   ||||:|||:|||||.||   |.:.|.|::||       ||..||||
Frog   274 NLNALHSPDPDS---FYPGIPSSINPAFFQSF---SGNPCPGINVP-------GFSSPFSA---- 321

Human   499 PPPPPAMNIPQQQPPPPAAPQQPQSRRSPVSPQLQQQHQAAAAAFLQQRNSYNHHQPLLKQSPWS 563
                 .:||||         ||.|||||||||||..||. .||||||||||||||||::||||||
Frog   322 -----QINIPQ---------QQQQSRRSPVSPQLNPQHH-QAAAFLQQRNSYNHHQPIVKQSPWS 371

Human   564 NHQSSGWGTGSMSWGAMHGRDHRRTGNMGIPGTMNQISPLKKPFSGNVIAPPKFTRSTPSLTPKS 628
            .||||||.|||||||.:|.||||||||||:||.|:||||||||:|||||||||||||||||||||
Frog   372 GHQSSGWSTGSMSWGGIHARDHRRTGNMGMPGNMSQISPLKKPYSGNVIAPPKFTRSTPSLTPKS 436

Human   629 WIEDNVFRTDNNSNTLLPLQVRMVRSSLQLPAWGSDSLQDSWCTAAGTSRIDQDRSRMYDSLNMH 693
            |||||||||||||||||||||||                              ||||||||||||
Frog   437 WIEDNVFRTDNNSNTLLPLQVRM------------------------------DRSRMYDSLNMH 471

Human   694 SLENSLIDIMRAEHDPLKGRLSYPHPGTDNLLMLNARSYGRRRGRSSLFPIDDGLLDDGHSDQVG 758
            |||||||:|||||||||||||:|||||||:||||||||||||||||||||:|||||||||:||||
Frog   472 SLENSLIEIMRAEHDPLKGRLNYPHPGTDSLLMLNARSYGRRRGRSSLFPLDDGLLDDGHNDQVG 536

Human   759 VLNSPTCYSAHQNGERIERFSRKVFVGGLPPDIDEDEITASFRRFGPLVVDWPHKAESKSYFPPK 823
            |||||.|||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||
Frog   537 VLNSPNCYSGHQNGERIERFSRKVFVGGLPPDIDEDEITASFRRFGPLVVDWPHKAESKSYFPPK 601

Human   824 GYAFLLFQEESSVQALIDACIEEDGKLYLCVSSPTIKDKPVQIRPWNLSDSDFVMDGSQPLDPRK 888
            |||||||||||||||||||||||:|||||||||||||||||||||||||||||||||||||||||
Frog   602 GYAFLLFQEESSVQALIDACIEEEGKLYLCVSSPTIKDKPVQIRPWNLSDSDFVMDGSQPLDPRK 666

Human   889 TIFVGGVPRPLRAVELAMIMDRLYGGVCYAGIDTDPELKYPKGAGRVAFSNQQSYIAAISARFVQ 953
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Frog   667 TIFVGGVPRPLRAVELAMIMDRLYGGVCYAGIDTDPELKYPKGAGRVAFSNQQSYIAAISARFVQ 731

Human   954 LQHGDIDKRVEVKPYVLDDQMCDECQGARCGGKFAPFFCANVTCLQYYCEFCWANIHSRAGREFH 1018
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Frog   732 LQHGDIDKRVEVKPYVLDDQMCDECQGARCGGKFAPFFCANVTCLQYYCEFCWANIHSRAGREFH 796

Human  1019 KPLVKEGADRPRQIHFRWN 1037
            |||||||||||||||||||
Frog   797 KPLVKEGADRPRQIHFRWN 815

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CPEB2	XP_005248192.2	RRM	<767..942	CDD:223796	172/174 (99%)
		RRM1_CPEB2_like	780..871	CDD:241168	89/90 (99%)
		RRM2_CPEB2_like	888..968	CDD:241170	79/79 (100%)
		CEBP_ZZ	963..1024	CDD:292976	60/60 (100%)
cpeb2	XP_004911287.2	RRM1_CPEB2_like	558..649	CDD:410123	89/90 (99%)
		RRM2_CPEB2_like	666..746	CDD:410125	79/79 (100%)
		CEBP_ZZ	741..802	CDD:406704	60/60 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	191	1.000	Domainoid score	I16268
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	984	1.000	Inparanoid score	I3198
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1075356at2759
OrthoFinder	1	1.000	-	-		FOG0001410
OrthoInspector	1	1.000	-	-		oto148443
Panther	1	1.100	-	-	LDO	PTHR12566
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X879
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.160