DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MAP3K8 and dlg-1

DIOPT Version :9

Sequence 1:	NP_001231063.1	Gene:	MAP3K8 / 1326	HGNCID:	6860	Length:	467	Species:	Homo sapiens
Sequence 2:	NP_001024431.1	Gene:	dlg-1 / 180819	WormBaseID:	WBGene00001006	Length:	967	Species:	Caenorhabditis elegans

Alignment Length:	148	Identity:	33/148 - (22%)
Similarity:	61/148 - (41%)	Gaps:	30/148 - (20%)

- Green bases have known domain annotations that are detailed below.

Human   204 HLFMEAGE-----GGSVLEKLESCGPMREFEIIWVTKHVLKGLDFLHSKKVIHHDIKPSNIVFMS 263
            :||:|||:     .|:.::.:..........|:.|:.:.::.|....:.:.|...||||     |
Worm   830 NLFIEAGQFQNNLYGTSIQSVRDVANQGRHCILDVSGNAIRRLQSNANIQPISIFIKPS-----S 889

Human   264 TKAVL-VDFGLSVQMTEDVYFPKDLRGTEI---YMSPEVI-----------LCRGHSTKADIYSL 313
            .:.:| :|..|:....:|    :.:.|.|.   |.....|           :...||.. |:.|.
Worm   890 AQQILELDSQLATNRQDD----RAMSGEEAQAQYSRCHRIEQTFGDLFTQEISNVHSAN-DVLSK 949

Human   314 GATLIHMQTGTPPWVKRY 331
            ..::|..::.||.||.|:
Worm   950 VYSIISRESQTPIWVPRH 967

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAP3K8	NP_001231063.1	STKc_MAP3K8	133..388	CDD:270897	33/148 (22%)
dlg-1	NP_001024431.1	L27_1	7..63	CDD:312556
		PDZ	199..289	CDD:214570
		PDZ_signaling	361..445	CDD:238492
		PDZ	507..591	CDD:214570
		SH3_DLG-like	623..684	CDD:212795
		GuKc	776..944	CDD:214504	25/122 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910