DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SCLT1 and unc-54

DIOPT Version :9

Sequence 1:	XP_016863205.1	Gene:	SCLT1 / 132320	HGNCID:	26406	Length:	692	Species:	Homo sapiens
Sequence 2:	NP_493596.1	Gene:	unc-54 / 259839	WormBaseID:	WBGene00006789	Length:	1963	Species:	Caenorhabditis elegans

Alignment Length:	959	Identity:	202/959 - (21%)
Similarity:	353/959 - (36%)	Gaps:	311/959 - (32%)

- Green bases have known domain annotations that are detailed below.

Human    10 EQNRRLNEDFRRYQMESFSKYSSVQKAVCQGEGDDTFENLVFDQSFLAPLVTEYDKHLGELNGQL 74
            |.||:|.||.:  ..|....:.:..||..:...||..::|..::...|.|    ||...::.|:|
Worm  1010 EINRKLMEDLQ--SEEDKGNHQNKVKAKLEQTLDDLEDSLEREKRARADL----DKQKRKVEGEL 1068

Human    75 KYYQKQV---GEMKLQLENVIKENE-RLH---------------------------SELKDAVEK 108
            |..|:.:   |..:..|||.:|:.| .||                           |||::.:|.
Worm  1069 KIAQENIDESGRQRHDLENNLKKKESELHSVSSRLEDEQALVSKLQRQIKDGQSRISELEEELEN 1133

Human   109 KLEAFPLGTEVGTDIYAD--------DE------------------------------------- 128
            :.::........:|:..:        ||
Worm  1134 ERQSRSKADRAKSDLQRELEELGEKLDEQGGATAAQVEVNKKREAELAKLRRDLEEANMNHENQL 1198

Human   129 ---------TVRNLQEQLQLAN-------QEKTQAVELWQTVSQELD----------RLHKLYQE 167
                     .|..|.:||...|       ::|.|||...:.::.:||          :|.|.::.
Worm  1199 GGLRKKHTDAVAELTDQLDQLNKAKAKVEKDKAQAVRDAEDLAAQLDQETSGKLNNEKLAKQFEL 1263

Human   168 HMTEAQIHVFESQKQKDQLFDFQQLTKQLHVTN----ENMEVTNQQFLKTVTEQSVIIEQLRKKL 228
            .:||.|   .::.:|..||.||..|..:||..|    ..:|....|..:....:|.:..||.:..
Worm  1264 QLTELQ---SKADEQSRQLQDFTSLKGRLHSENGDLVRQLEDAESQVNQLTRLKSQLTSQLEEAR 1325

Human   229 RQAKLELR-----VAVAK-----VEEL-TNVTEDLQG------QMKKKEKDV------------V 264
            |.|..|.|     .|.||     .|:| .::.|:::|      |:.|...|:            :
Worm  1326 RTADEEARERQTVAAQAKNYQHEAEQLQESLEEEIEGKNEILRQLSKANADIQQWKARFEGEGLL 1390

Human   265 SAHGREEASDRRLQQL-------------QSSIKQLEIRLCVTIQEANQLRTENTH-----LEKQ 311
            .|...|:|..|:.|::             .:|:::.:.||...:.:| |:..|..:     |||:
Worm  1391 KADELEDAKRRQAQKINELQEALDAANSKNASLEKTKSRLVGDLDDA-QVDVERANGVASALEKK 1454

Human   312 TR-------ELQAKCNELENERYEAIVRARN-SMQLLEEANLQKSQALLEEKQKEEDIEKMKETV 368
            .:       |.:.|.::|..|...|....|| |..|.:..|.|:..|.:.|..:.|:     :::
Worm  1455 QKGFDKIIDEWRKKTDDLAAELDGAQRDLRNTSTDLFKAKNAQEELAEVVEGLRREN-----KSL 1514

Human   369 SRFVQDATI------RTKKEVANTKKQCNIQISRL------------TEELSAL--QMECAEKQG 413
            |:.::|.|.      |:..|:....::..|:...|            .||...|  |:|.::.:.
Worm  1515 SQEIKDLTDQLGEGGRSVHEMQKIIRRLEIEKEELQHALDEAEAALEAEESKVLRAQVEVSQIRS 1579

Human   414 QIERVIKEKKAVEEELEKPFLQIYREGRGNESDYRKLEEMHQRFLVSERSKDDLQLRLTRAENRI 478
            :||:.|:||   |||.|..        |.|.:  |.||.|........:.|.:|.....:.|..|
Worm  1580 EIEKRIQEK---EEEFENT--------RKNHA--RALESMQASLETEAKGKAELLRIKKKLEGDI 1631

Human   479 KQLE----------TDSSEEISRYQEMIQKLQ------------------------NVLESEREN 509
            .:||          .|:.:.:.||||.:::||                        .:|:||:|.
Worm  1632 NELEIALDHANKANADAQKNLKRYQEQVRELQLQVEEEQRNGADTREQFFNAEKRATLLQSEKEE 1696

Human   510 CGLVSE--QRLKLQQE-------------NKQLRKETESLRKI--------------------AL 539
            ..:.:|  :|.:.|.|             |.|:...|.:.||:                    |.
Worm  1697 LLVANEAAERARKQAEYEAADARDQANEANAQVSSLTSAKRKLEGEIQAIHADLDETLNEYKAAE 1761

Human   540 EAQKKAKVKISTMEHEFSIKE----------RGFEVQLREME-----------DSNRNSIVEL-- 581
            |..|||....:.:..|...::          :|.|.||:|::           ...:..|.:|
Worm  1762 ERSKKAIADATRLAEELRQEQEHSQHVDRLRKGLEQQLKEIQVRLDEAEAAALKGGKKVIAKLEQ 1826

Human   582 --RHLLATQQKAANRWKEETKKLTESAEIRINNLKSELSRQKLHTQELLSQLEMANEKVAENEKL 644
              |.|.:.......|:::..|.|.. |:.|:..|:.::...|.:.:.|...::...:|:...:|.
Worm  1827 RVRELESELDGEQRRFQDANKNLGR-ADRRVRELQFQVDEDKKNFERLQDLIDKLQQKLKTQKKQ 1890

Human   645 ILEHQEKAN-------RLQRRLSQAEERAASASQQLSVITVQRRKAASL 686
            :.|.:|.||       :|..:|..|||||..|...||.:..:.|.:||:
Worm  1891 VEEAEELANLNLQKYKQLTHQLEDAEERADQAENSLSKMRSKSRASASV 1939

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SCLT1	XP_016863205.1	None
unc-54	NP_493596.1	Myosin_N	31..68	CDD:280832
		Myosin_head	83..775	CDD:278492
		MYSc_class_II	95..775	CDD:276951
		Myosin_tail_1	855..1932	CDD:279860	199/950 (21%)
		Prefoldin	903..>969	CDD:298833
		YlqD	946..>1020	CDD:287979	6/9 (67%)
		GluZincin	1649..>1784	CDD:301352	25/134 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000