DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SCLT1 and epi-1

DIOPT Version :9

Sequence 1:	XP_016863205.1	Gene:	SCLT1 / 132320	HGNCID:	26406	Length:	692	Species:	Homo sapiens
Sequence 2:	NP_001294008.1	Gene:	epi-1 / 177956	WormBaseID:	WBGene00001328	Length:	3715	Species:	Caenorhabditis elegans

Alignment Length:	604	Identity:	130/604 - (21%)
Similarity:	232/604 - (38%)	Gaps:	151/604 - (25%)

- Green bases have known domain annotations that are detailed below.

Human    88 LENVIKENERLHSELKDAVEKKLEAFPLGTEVGTD---IYADDETVRNLQEQLQ-LANQEKTQAV 148
            |:.|:|..:|....::...|       :...:|:.   :..|...::..:|.|. |......|..
Worm  2251 LQEVMKRAQRARQSVRSLAE-------IALAIGSSSKAVNVDPRLLKEAEETLMTLEAASADQYP 2308

Human   149 ELWQTVSQELDRLHKLYQE--HMTEAQIHVFESQKQKDQLFDFQQLTKQLHVTNENMEVTNQQFL 211
            |..|||..:|:.:.|..||  ...:.|...||:||::     .::|...|:        :.||.|
Worm  2309 EKAQTVPGKLEEIQKKIQEETEKLDKQKETFEAQKKR-----AEELAAYLN--------SAQQLL 2360

Human   212 KTVTEQSVIIEQLRKKLRQAKLELRVAVAKVEELTNVTEDLQGQMKKKEKDVVSAHGREEASDRR 276
            |....::.....:.|.|:..|:|..||.        :|:||:               |.||:...
Worm  2361 KESKSKADKSNNIAKMLQLTKVENLVAA--------ITDDLE---------------RVEAAKGE 2402

Human   277 LQQLQSSIKQLEIRLCVTIQEANQLRTENTHLEKQTRELQAKCNELENERYEAIVRARN------ 335
            .|:|..:|..:       .:.....|.|.||       .....||..|:..||:..|:.
Worm  2403 FQKLNVAIGNI-------TENLKDKREEMTH-------AVTTLNETRNDVAEALEAAKKRVRRDE 2453

Human   336 ---SMQLLEEANLQKSQALLEEKQKEEDIEKMKETVSRFVQDATIRTKKEVANTKKQCNIQISRL 397
               .|||:   |.:..:..|:.....:..:..|:...:.|:.|  .....:.:|.|....||...
Worm  2454 KSVDMQLV---NAKAHELHLQATTLRQTFDNNKDNTDQAVEAA--NAFSNLTDTLKNAKAQIDNA 2513

Human   398 TEELSALQMECAEKQGQIERVIKEKKAVEEELEKPFLQIYREGRGNESDYRKLEEMHQRFLVSER 462
            .|.|||            |....|  :|:...:|||....:|         |::.:.:  .||:.
Worm  2514 YEALSA------------EPAFAE--SVQNARDKPFPDETKE---------KIDALSK--TVSQD 2553

Human   463 SKDDLQLRLTRAENRIKQLE--TDSSEEISRYQEMIQK-----LQNVLESERENCGLVSEQRLKL 520
            .|:..:|:        ||||  |:.||::.:.:|.::.     .:|.|:|..|....|.:.:.::
Worm  2554 LKETEKLK--------KQLEQLTELSEKLRKRKEAVKAGIPKYSKNTLDSIDEKVQEVEKLKAEI 2610

Human   521 QQENKQLRKETESLRKIALEAQKKAKVKISTMEHEFSIKERGFEVQLREMEDSNRNSIVELRHLL 585
            ....::.|.:...:...|.|..:||.   |.||        |..:       :.||| |:|..|.
Worm  2611 DANIEETRAKISEIAGKAEEITEKAN---SAME--------GIRL-------ARRNS-VQLNKLA 2656

Human   586 ATQQKAANRWKEETKKLTESAEIRINNLKSELSRQKLHTQELLSQLEM-ANEKVAENEKLILEHQ 649
            ..   ..::: ||.|||:.:...:::::..::|:.|          || |..:.|.|...:..|.
Worm  2657 PV---IVSKF-EELKKLSSARSAKVDSVSDKVSQIK----------EMIAVARDAANRIKLGAHF 2707

Human   650 EKANRLQRRLSQAEERAAS 668
            ||.:.|...:.|...|:|:
Worm  2708 EKGSSLDLNIPQRVTRSAA 2726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SCLT1	XP_016863205.1	None
epi-1	NP_001294008.1	LamNT	24..296	CDD:214532
		EGF_Lam	297..345	CDD:238012
		Laminin_EGF	427..474	CDD:278482
		EGF_Lam	471..520	CDD:238012
		EGF_Lam	519..564	CDD:214543
		Laminin_EGF	564..612	CDD:278482
		Laminin_EGF	610..658	CDD:278482
		Laminin_EGF	656..703	CDD:278482
		Laminin_EGF	701..753	CDD:278482
		Laminin_EGF	756..806	CDD:278482
		EGF_Lam	808..854	CDD:238012
		CBM6-CBM35-CBM36_like	855..988	CDD:271143
		EGF_Lam	1425..1468	CDD:238012
		EGF_Lam	1472..1515	CDD:238012
		Laminin_EGF	1517..1567	CDD:278482
		Laminin_EGF	1565..1613	CDD:278482
		LamB	1669..1793	CDD:214597
		EGF_Lam	1840..1883	CDD:238012
		Laminin_EGF	1891..1945	CDD:278482
		EGF_Lam	1947..1998	CDD:238012
		EGF_Lam	2001..2045	CDD:214543
		EGF_Lam	2048..2092	CDD:214543
		EGF_Lam	2095..2140	CDD:214543
		Tar	<2145..2378	CDD:223910	31/146 (21%)
		BAR	2289..2486	CDD:299863	54/249 (22%)
		Apolipoprotein	2289..2472	CDD:279749	53/235 (23%)
		COG1340	2414..2690	CDD:224259	73/353 (21%)
		ApoLp-III_like	2510..2635	CDD:304399	33/157 (21%)
		Laminin_II	2589..2730	CDD:283628	39/171 (23%)
		LamG	2704..2875	CDD:238058	7/23 (30%)
		LamG	2909..3057	CDD:238058
		LamG	3353..3510	CDD:238058
		LamG	3532..3682	CDD:238058
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910