DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ddx3x and mahe

DIOPT Version :9

Sequence 1:	NP_034158.1	Gene:	Ddx3x / 13205	MGIID:	103064	Length:	662	Species:	Mus musculus
Sequence 2:	NP_001284994.1	Gene:	mahe / 31707	FlyBaseID:	FBgn0029979	Length:	945	Species:	Drosophila melanogaster

Alignment Length:	742	Identity:	243/742 - (32%)
Similarity:	351/742 - (47%)	Gaps:	133/742 - (17%)

- Green bases have known domain annotations that are detailed below.

Mouse     8 NALGLDQQFAGLDLNSSDNQSGGSTASKGRYIPPHLRNREATKGFYDKDSSGWSS--SKDKDAYS 70
            ||.|:.|...|   ....|.:.......|...|.|.|.      :|.:.:.|.::  :....|.:
  Fly     9 NAGGVQQHTGG---GYYGNGAAAGAGGSGNGAPRHERQ------YYPRGNFGGAAGGAGINGAAT 64

Mouse    71 SFGSR--GDSRGKSSF-------FGDRGSGSRG--------RFDDRGRGDYDGIGGRGDRSGFGK 118
            :.||.  |...|..::       .|..|||...        .|...|.|...| ||.|...|:|.
  Fly    65 AAGSMHFGQPYGVMTYGIQNGLGMGAAGSGGGNPYRQQNGVAFAGNGLGGGAG-GGSGGSGGYGG 128

Mouse   119 FERGGNSRWCDKSDEDDWSKP----------------------LPPSERLEQELFSGGNTGINFE 161
             :||.|..:..:     :.||                      |...||.|.:.....|.|.|..
  Fly   129 -QRGKNPTYAQR-----YQKPNNGAGVAGGYQSNNYNAAALGMLSKEERAEIQREKAKNPGRNLV 187

Mouse   162 K-------------YD------------------DIPVEATGNNCPPHIESFSDVEMGEIIMGNI 195
            |             |:                  ::.:..:||..|..:.||.:..:...::..:
  Fly   188 KPKWENLEPFLKDFYNIHPNTLAKSEQQVAEIRRELEITVSGNELPHPVVSFEESSLPAHVIEEM 252

Mouse   196 ELTRYTRPTPVQKHAIPIIKEKRDLMACAQTGSGKTAAFLLPILSQIYADGP---GEALRAMKEN 257
            :...:|:||.:|....||....|||:..||||||||.|::||.:..|....|   ||.
  Fly   253 KRQGFTKPTAIQSQGWPIALSGRDLVGIAQTGSGKTLAYMLPAIVHIGNQPPIIRGEG------- 310

Mouse   258 GRYGRRKQYPISLVLAPTRELAVQIYEEARKFSY--RSRVRPCVVYGGAEIGQQIRDLERGCHLL 320
                     ||:||||||||||.||....|.:.:  :..:|...::||:....|.|||:||..::
  Fly   311 ---------PIALVLAPTRELAQQIQSVVRDYGHLCKPEIRHTCIFGGSSKVPQARDLDRGVEVI 366

Mouse   321 VATPGRLVDMMERGKIGLDFCKYLVLDEADRMLDMGFEPQIRRIVEQDTMPPKGVRHTMMFSATF 385
            :||||||:|.:|.....|..|.||||||||||||||||||||:|:||  :.|.  |..:|:|||:
  Fly   367 IATPGRLIDFLENRNTNLQRCTYLVLDEADRMLDMGFEPQIRKIIEQ--IRPD--RQVVMWSATW 427

Mouse   386 PKEIQMLARDFLDEYIFLAVGRVG-STSENITQKVVWVEEIDKRSFLLDLL-------NATGKDS 442
            |||:|.||.|||::||.:.:|.:. |.:.||.|.|....||:|...|:.||       |:....:
  Fly   428 PKEVQALAGDFLNDYIQINIGSMNLSANHNIRQIVEICTEIEKPQRLVCLLNEISPIKNSGNNGN 492

Mouse   443 LTLVFVETKKGADSLEDFLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVAARGLDI 507
            ..:||||||...:.:...:..|||..||||||::|.:|:..|..||:|||.||:||.||:||||:
  Fly   493 KIIVFVETKIKVEDILQIIRAEGYNATSIHGDKTQNERDSVLKDFRNGKSNILIATDVASRGLDV 557

Mouse   508 SNVKHVINFDLPSDIEEYVHRIGRTGRVGNLGLATSFFNERNINITKDLLDLLVEAKQEVPSWLE 572
            .::::|||:|.|:..|.||||||||||...||.|.:||...|....::|:.:|.||.|.....|.
  Fly   558 EDLQYVINYDYPNSSENYVHRIGRTGRCQQLGTAYTFFTPDNAKQARELISVLEEAGQTPSQALL 622

Mouse   573 NMAFEHHYKGSSRGRSKSSRFSGG---FGARD--YRQSSGASSSSFSSSRASSSRSGGGGHGGSR 632
            ::|......|..||..:.:..|||   .|..:  |:|.:....:..:.:..:::|||.......:
  Fly   623 DLARSMPSSGGYRGNKRWNNNSGGDRNTGGNNGIYQQRNNNPLNYQAGNNYNNNRSGPPTGSSYQ 687

Mouse   633 GFGGGGYGGFYNSDGYGGNYNSQGVDW 659
            .:..|  |..|..:|.||     ||:|
  Fly   688 QYAAG--GNTYLQNGAGG-----GVNW 707

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ddx3x	NP_034158.1	Required for TBK1 and IKBKE-dependent IFNB1 activation. /evidence=ECO:0000250\|UniProtKB:O00571	2..139		33/149 (22%)
		Nuclear export signal. /evidence=ECO:0000250\|UniProtKB:O00571	12..21		2/8 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	19..144		31/165 (19%)
		Interaction with EIF4E. /evidence=ECO:0000250\|UniProtKB:O00571	38..44		2/5 (40%)
		PTZ00110	57..580	CDD:240273	211/607 (35%)
		eIF-4B	80..>172	CDD:283846	28/159 (18%)
		Interaction with GSK3B. /evidence=ECO:0000250\|UniProtKB:O00571	100..662		221/631 (35%)
		Interaction with IKBKE. /evidence=ECO:0000250\|UniProtKB:O00571	100..110		4/9 (44%)
		Interaction with CHUK. /evidence=ECO:0000250\|UniProtKB:O00571	139..172		10/85 (12%)
		Q motif	180..208		5/27 (19%)
		DEADc	182..404	CDD:238167	99/226 (44%)
		Involved in stimulation of ATPase activity by DNA and RNA, nucleic acid binding and unwinding. /evidence=ECO:0000250\|UniProtKB:O00571	250..259		0/8 (0%)
		DEAD box	347..350		2/2 (100%)
		Helicase_C	426..536	CDD:278689	54/116 (47%)
		Interaction with NXF1. /evidence=ECO:0000250\|UniProtKB:O00571	536..661		34/129 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	601..633		5/33 (15%)
mahe	NP_001284994.1	PTZ00110	136..656	CDD:240273	196/544 (36%)
		DEADc	239..446	CDD:238167	99/226 (44%)
		HELICc	457..594	CDD:238034	63/136 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53695
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	4	3.880