DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dhx15 and l(2)37Cb

DIOPT Version :9

Sequence 1:	NP_031865.2	Gene:	Dhx15 / 13204	MGIID:	1099786	Length:	795	Species:	Mus musculus
Sequence 2:	NP_609946.1	Gene:	l(2)37Cb / 35192	FlyBaseID:	FBgn0086444	Length:	894	Species:	Drosophila melanogaster

Alignment Length:	797	Identity:	371/797 - (46%)
Similarity:	495/797 - (62%)	Gaps:	75/797 - (9%)

- Green bases have known domain annotations that are detailed below.

Mouse     1 MSKRHRLDLGEDYPSGKKRAGTDGKDRERDRDREDRSK-DRDRERDRGDRER-----EREKEKEK 59
            ::||.:.:  .:|   ||:.....|:.|:.|:.|...: :..::..:|:|..     |.||:...
  Fly   118 LTKREKEE--REY---KKQLLNIAKEHEKARELERIQRYNMPQDLKKGERSEYVEVDEFEKQPNS 177

Mouse    60 ELRASTNAMLISA----GLPPLKASH-------------SAHSTHSAHSTHSTHSAHSTHTGHTG 107
            |.:......|.||    |....||..             .|.:...:....|:.....|......
  Fly   178 EQKKWEAEQLASARFHFGAKDAKAEEEYELLLDDQIDFIQALTLDGSREKSSSRQPELTEKERKR 242

Mouse   108 HTSLPQCINPFTNLPHTPRYYDILKKRLQLPVWEYKDRFTDILVRHQSFVLVGETGSGKTTQIPQ 172
            .|           |..|         |..|||:.:|:.....:..||..::.||||||||||:||
  Fly   243 LT-----------LDET---------RRSLPVYPFKEDLIAAVKEHQVLIIEGETGSGKTTQVPQ 287

Mouse   173 WCVEYMRSLPGPKRGVACTQPRRVAAMSVAQRVADEMDVMLGQEVGYSIRFEDCSSAKTILKYMT 237
            :.||  ......|:.:.|||||||||||||.|||:||.|.||.|||||||||||:|.:|||||||
  Fly   288 YLVE--AGFTKDKKMIGCTQPRRVAAMSVAARVAEEMGVKLGNEVGYSIRFEDCTSDRTILKYMT 350

Mouse   238 DGMLLREAMNDPLLERYGVIILDEAHERTLATDILMGVLKEVVRQRSDLKVIVMSATLDAGKFQI 302
            ||.|.||.:::|.|..|.|:|:||||||||.||||.|::|::.|.|.:||:::.||||||.||..
  Fly   351 DGTLHREFLSEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPELKLLISSATLDAEKFSA 415

Mouse   303 YFDNCPLLTIPGRTHPVEIFYTPEPERDYLEAAIRTVIQIHMCEEEEGDLLLFLTGQEEIDEACK 367
            :||:.|:..||||.:||:||||..||.||::|...:|:||| ..:..||:|:|||||:|| |.|:
  Fly   416 FFDDAPIFRIPGRRYPVDIFYTKAPEADYIDACCVSVLQIH-ATQPLGDILVFLTGQDEI-ETCQ 478

Mouse   368 -----RIKREVDDLGPEVGDIKIIPLYSTLPPQQQQRIFEPPPPKKQNGAIGRKVVVSTNIAETS 427
                 |:||    ||.::.::.:||:|:.||...|.:||||.||.      .|||:::|||||||
  Fly   479 EVLHDRVKR----LGSKIRELIVIPVYANLPSDMQAKIFEPTPPN------ARKVILATNIAETS 533

Mouse   428 LTIDGVVFVIDPGFAKQKVYNPRIRVESLLVTAISKASAQQRAGRAGRTRPGKCFRLYTEKAYKT 492
            ||||.:::|||||||||..:|.|..:|||:|..||||||.|||||||||.|||||||||..|||.
  Fly   534 LTIDNIIYVIDPGFAKQNNFNSRTGMESLMVVPISKASANQRAGRAGRTAPGKCFRLYTAWAYKH 598

Mouse   493 EMQDNTYPEILRSNLGSVVLQLKKLGIDDLVHFDFMDPPAPETLMRALELLNYLAALNDDGDLTE 557
            |::|||.|||.|.|||:.||.||.|||:||:||||:|||..|||:.|||.|..|.|||..|:||:
  Fly   599 ELEDNTVPEIQRINLGNAVLMLKALGINDLIHFDFLDPPPHETLVLALEQLYALGALNHHGELTK 663

Mouse   558 LGSMMAEFPLDPQLAKMVIASCDYNCSNEVLSITAMLSVPQC-FVRPTEAKKAADEAKMRFAHID 621
            ||..|||||:||.:.||::||..|.||.|:::|.|||||... |.||.:....||.|:..|.|:.
  Fly   664 LGRRMAEFPVDPMMGKMLLASEKYKCSEEMVTIAAMLSVNSAIFYRPKDKIIHADTARKNFNHMH 728

Mouse   622 GDHLTLLNVYHAFKQNHESVQWCYDNFINYRSLMSADNVRQQLSRIMDRFNLPRRSTDFTS-RDY 685
            ||||:||.||:.:.:...|.||||:|||.|||:..|.:||:||..:|.|..:     |..| ...
  Fly   729 GDHLSLLQVYNQWAETDYSTQWCYENFIQYRSMKRARDVREQLVGLMQRVEI-----DMVSCLPE 788

Mouse   686 YINIRKALVTGYFMQVAHLERTGHYLTVKDNQVVQLHP-STVLDHKPEWVLYNEFVLTTKNYIRT 749
            .:|:|||...|||..||.|.:.|||.|:|.||.|.:|| |::.:..|.||||:|.|.|:|.|:|.
  Fly   789 TVNVRKAATAGYFYHVARLSKGGHYKTIKHNQTVMIHPNSSLFEELPRWVLYHELVFTSKEYMRQ 853

Mouse   750 CTDIKPEWLVKIAPQYY 766
            ..:|:.:||:::||.||
  Fly   854 VIEIESKWLLEVAPHYY 870

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dhx15	NP_031865.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..111		25/132 (19%)
		HrpA	124..763	CDD:224557	341/646 (53%)
		DEAH box	260..263		2/2 (100%)
l(2)37Cb	NP_609946.1	HrpA	222..867	CDD:224557	345/683 (51%)
		DEXDc	269..408	CDD:238005	86/140 (61%)
		HELICc	491..581	CDD:197757	53/95 (56%)
		HA2	651..735	CDD:214852	42/83 (51%)
		OB_NTP_bind	770..869	CDD:285018	43/103 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53574
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X141
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.730