Protein Alignment Dctn1 and DCTN1-p150

DIOPT Version :10

• Sequence 1: NP_031861.2
• Gene: Dctn1 / 13191
• MGIID: 107745
• Length: 1281
• Species: Mus musculus
• Sequence 2: NP_524061.1
• Gene: DCTN1-p150 / 39536
• FlyBaseID: FBgn0001108
• Length: 1265
• Species: Drosophila melanogaster
• Alignment Length: 1287
• Identity: 428/1287 - (33%)
• Similarity: 695/1287 - (54%)
• Gaps: 110/1287 - (8%)

Mouse    23 SARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGVILDEAKGKNDGTVQGRKYFTCDEGHGI 87
            |.:.|:||:|||:.||...|||||||.|.||.||||||:|||.||||.|:::|::||.|||..|:
  Fly     2 SEKNLKVGARVELTGKDLLGTVAYVGMTSFAVGKWVGVVLDEPKGKNSGSIKGQQYFQCDENCGM 66

Mouse    88 FVRQSQIQVFEDGADTTSPETPDSSASKVLKREGADAAAKTSKLRGLKPKKAPTARKTTTRRPKP 152
            |||.:|:::.| .|..:.....|.|.:.....:...|...:|:......:::....:|.......
  Fly    67 FVRPTQLRLLE-AAPGSRRSIEDVSGATPTAAQPTKARLSSSRTSLSSSRQSLLGSRTQLTTSLS 130

Mouse   153 TRPASTGVAGPSSSLGPSGS----------------ASAGELSSSEPS----------------- 184
            .|.||:...||..||.|..|                ||.|..::|..|
  Fly   131 ERTASSSSIGPRKSLAPQNSKDKESPSTSLAEGAPAASGGNGAASHASSKRASFVETGFLEILKP 195

Mouse   185 --TPAQTPLAAPIIPTPALTSPGAAPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRSEDKAKLKE 247
              ||:| ||.:|....|:.:.......|....|....|:||:.||.||||||:.:|:|||.:|:|
  Fly   196 QFTPSQ-PLRSPSFTMPSNSGAEDKVALLEAQKTSAELQAQLADLTEKLETLKQRRNEDKERLRE 259

Mouse   248 LEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKE 312
            .:|.|||.||:||:::|:...||.||:.|..|::|||:|:||||::.:||||.||.:||.|||||
  Fly   260 FDKMKIQFEQLQEFRTKIMGAQASLQKELLRAKQEAKDAIEAKEQHAQEMADLADNVEMITLDKE 324

Mouse   313 MAEERAESLQQEVEALKERVDELTTDLEILKAEIEEK-----------GSDGAASSYQLKQLEEQ 366
            ||||:|::||.|:|:.|||::||..|||:|::|::.|           |.....|:|:.||||:|
  Fly   325 MAEEKADTLQLELESSKERIEELEVDLELLRSEMQNKAESAIGNISGGGDSPGLSTYEFKQLEQQ 389

Mouse   367 NARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVD 431
            |.|||:.|||:||||:.:|.:..||.|.:|.|..|:..:.:.:|:|..::.:.|:.:.:|:||||
  Fly   390 NIRLKETLVRLRDLSAHDKHDIQKLSKELEMKRSEVTELERTKEKLSAKIDELEAIVADLQEQVD 454

Mouse   432 AALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARV 496
            ||||||||||.|.::.:.||:||:.|.|.:..|||:.|::::|.|:..|.||:|||:||:|....
  Fly   455 AALGAEEMVEQLAEKKMELEDKVKLLEEEIAQLEALEEVHEQLVESNHELELDLREELDLANGAK 519

Mouse   497 REAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPP-----PETFDFK 556
            :|..:..:||.||:.|..|||.|:|:|...|.|...||.::..::.:...|.|     .||.|:|
  Fly   520 KEVLRERDAAIETIYDRDQTIVKFRELVQKLNDQLTELRDRNSSNEKESLQDPSLKMVTETIDYK 584

Mouse   557 IKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAEL 621
            ..|||:||:.:||:::|||:|::|||.|:.:||||||:||:..|||||.:||:||:.|::.|.::
  Fly   585 QMFAESKAYTRAIDVQLRQIELSQANEHVQMLTAFMPESFMSRGGDHDSILVILLISRIVFKCDI 649

Mouse   622 IRKQAQEKFDLSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVG 686
            :..|.:|:|...:..:.....:|.|.:|.:|...|::.:..||..||:..:.|:.|..|...:.|
  Fly   650 VVSQTRERFPPVDAITREAVTQGHAVQQYAFKCRLLHYVHSLQCALHQILYGLNSCQPDTLLRAG 714

Mouse   687 SLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLA-EQPEDSTMQLADHI 750
            |..|||.|.|:.:|.:||||..:||||....:.:.|.:.::..:.|:.|| ||..:....:.|.:
  Fly   715 SSLPEMVAQEKIVDGIIELLKSNQLDENSTTDNIEKCVAFFNAMNSVLLAGEQLLNEIQMIRDCV 779

Mouse   751 KFTQSALDCMGVEVGRLRAFLQGGQEATDIALLLRDLETSCSDTRQFCKKIRRRMPGTDAPGIPA 815
            ....:|.:.:..:....:..:|.....:|..||::.|..:....||..|.|:||:| :|...|.:
  Fly   780 ASLGAACESILSDTAIAKVIIQEAGATSDSVLLIQFLNENMESVRQQVKLIKRRLP-SDQHVIKS 843

Mouse   816 ALAFGSQVSDTLLDCRKHLTWVVAVL-----QEVAAAAAQLIAPLAENEGLPVAALEELAFKASE 875
            .|:  ....:.:....::::.:::.:     |.:||..:.:.:..|....||......|...:.|
  Fly   844 GLS--QHKVEAMRGLAQNISRIMSAMHQATKQSLAAIVSTIESDNAAEHTLPQEKYWALLTASCE 906

Mouse   876 QIYGSPSSSPYECLRQSCTILISTMNKLATAMQEGEYD----------AERPPSKPPPVELRAAA 930
            :||......|.:..:.......|.:..:|..:.:.|||          .::..:...|:..||..
  Fly   907 RIYEQDDRGPTQNFKTLLAQANSDLQLIAQHLLDKEYDIISAANNASNQQKSGAHSTPITQRAQL 971

Mouse   931 LRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQ 995
            ::.::.....|...||:||..:|:||.:.|:|..||||..:|..|.||||.....:.:..::|.:
  Fly   972 IKKQLEQKNVLAATLENREADVKQLKVAAKMKQNELSEMQIRKDLAEKKLSVLQNEYEHAVDKWK 1036

Mouse   996 TRLDETQTLLRKKEKDFEETMDALQADIDQLEAEKAEL--KQRLNSQSKRTIEGLRGPPPSGIAT 1058
            .:.:||...|:.|||:||||||.||:|||.||:||::|  |.:|||.:.:...|.....|..|:
  Fly  1037 QKYEETSLQLQLKEKEFEETMDHLQSDIDALESEKSDLRDKLKLNSTTGKVQPGSESHSPHNIS- 1100

Mouse  1059 LVSGIAGEEPQRGGAPGQAPGALPGPGLVKDSPLLLQQISAMRLHISQLQHENSILRGAQMKASL 1123
             :||.....|........||..        .:|::.:::..::...:|.:::...|:...|:|.|
  Fly  1101 -LSGNTSTAPGISNVSYSAPAG--------TAPVVAEEVELLKNAFNQERNQRLRLQAQDMRAKL 1156

Mouse  1124 AALPPLHVAKLSLPPHEGPGGNLVAGALYRKTSQLLEKLNQLSTHTHVVDI--TRSSPAAKS--- 1183
            :...||||.:    |.:            ::.:.|..:|.::. |..|:.:  .||..:..|
  Fly  1157 SQFEPLHVPQ----PQD------------QRITALESELTRMK-HAWVLSLLQVRSQDSVNSGTR 1204

Mouse  1184 ---PSAQLMEQVAQLK-SLSDTIEKLKDEVLKETVTQRPGATVPTDFATFPS 1231
               .:.|...|...|| .:|....:|..::|.|.:.::|.......||:||:
  Fly  1205 IDAVALQRRNQPVPLKGEISSKASQLASDILTEYLQRKPHRATHGQFASFPT 1256

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dctn1	NP_031861.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..26		1/2 (50%)
		CAP_GLY	29..94	CDD:460154	41/64 (64%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	100..221		29/155 (19%)
		Herpes_BLLF1	<101..>214	CDD:282904	28/147 (19%)
		SMC_prok_B	220..>540	CDD:274008	155/330 (47%)
		Dynactin	527..805	CDD:463591	93/283 (33%)
		Interaction with HPS6. /evidence=ECO:0000269|PubMed:25189619	911..1281		92/342 (27%)
		Smc	<926..>1046	CDD:440809	49/121 (40%)
DCTN1-p150	NP_524061.1	CAP_GLY	8..73	CDD:460154	41/64 (64%)
		NIP100	13..>272	CDD:227569	91/260 (35%)
		SMC_prok_B	<219..>497	CDD:274008	130/277 (47%)
		Dynactin	550..834	CDD:463591	93/283 (33%)
		Smc	<965..>1080	CDD:440809	46/114 (40%)