DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GRK7 and Grk6

DIOPT Version :9

Sequence 1:	NP_631948.1	Gene:	GRK7 / 131890	HGNCID:	17031	Length:	553	Species:	Homo sapiens
Sequence 2:	NP_113845.2	Gene:	Grk6 / 59076	RGDID:	61986	Length:	589	Species:	Rattus norvegicus

Alignment Length:	534	Identity:	244/534 - (45%)
Similarity:	352/534 - (65%)	Gaps:	20/534 - (3%)

- Green bases have known domain annotations that are detailed below.

Human     7 LDNLIANTAYLQARKPSDCDSKELQRR-RRSLALPGLQGCAELRQKLSLNFHSLCEQQPIGRRLF 70
            |:|::|||..|:||:....:.|...:: |:.|..|.:..|.|||..|..::|||||:|||||.||
  Rat     3 LENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERQPIGRLLF 67

Human    71 RDFLATVPTFRKAATFLEDVQNWELAEEGPTKDSA---LQGLVATCASAPAPGNPQPFLSQAVAT 132
            |:|.||.|...:...||:.|..:|:..:...|...   :|..::.......|..|:..:|.....
  Rat    68 REFCATRPELTRCTAFLDGVAEYEVTPDEKRKACGRRLMQNFLSHTGPDLIPEVPRQLVSNCAQR 132

Human   133 ----KCQAATTEEERVAAVTLAKAEAMAFLQEQPFKDFVTSAFYDKFLQWKLFEMQPVSDKYFTE 193
                .|:....|..|:....|:.|         ||.|::.|.::::|||||..|.|||:...|.:
  Rat   133 LEQGPCKDLFQELTRLTHEYLSMA---------PFADYLDSIYFNRFLQWKWLERQPVTKNTFRQ 188

Human   194 FRVLGKGGFGEVCAVQVKNTGKMYACKKLDKKRLKKKGGEKMALLEKEILEKVSSPFIVSLAYAF 258
            :|||||||||||||.||:.||||||||||:|||:||:.||.|||.||:|||||:|.|:||||||:
  Rat   189 YRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAY 253

Human   259 ESKTHLCLVMSLMNGGDLKFHIYNVGTRGLDMSRVIFYSAQIACGMLHLHELGIVYRDMKPENVL 323
            |:|..||||::||||||||||||::|..|...:|.:||:|:|.||:..||...|||||:||||:|
  Rat   254 ETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENIL 318

Human   324 LDDLGNCRLSDLGLAVEMKGGKPITQRAGTNGYMAPEILMEKVSYSYPVDWFAMGCSIYEMVAGR 388
            |||.|:.|:|||||||.:..|:.|..|.||.||||||::..: .|::..||:|:||.:|||:||:
  Rat   319 LDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNE-RYTFSPDWWALGCLLYEMIAGQ 382

Human   389 TPFKDYKEKVSKEDLKQRTLQDEVKFQHDNFTEEAKDICRLFLAKKPEQRLGSR-EKSDDPRKHH 452
            :||:..|:|:.:|:: :|.:::..:...|.|:.:|:.:|...|.|.|.:|||.| ..:.:.::|.
  Rat   383 SPFQQRKKKIKREEV-ERLVKEVAEEYTDRFSPQARSLCSQLLNKDPAERLGCRGGGAREVKEHP 446

Human   453 FFKTINFPRLEAGLIEPPFVPDPSVVYAKDIAEIDDFSEVRGVEFDDKDKQFFKNFATGAVPIAW 517
            .||.:||.||.||::||||.|||..:|.||:.:|:.||.|:||:.:..|:.|::.||||:|.|.|
  Rat   447 LFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDIEQFSTVKGVDLEPTDQDFYQKFATGSVSIPW 511

Human   518 QEEIIETGLFEELN 531
            |.|::||..|:|||
  Rat   512 QNEMVETECFQELN 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GRK7	NP_631948.1	RGS_GRK7	40..181	CDD:188703	46/147 (31%)
GRK7	NP_631948.1	STKc_GRK7	188..474	CDD:270758	154/286 (54%)
Grk6	NP_113845.2	N-terminal	1..185		61/190 (32%)
		RGS	35..179	CDD:295367	47/152 (31%)
		STKc_GRK6	185..469	CDD:270779	155/285 (54%)
		S_TKc	186..448	CDD:214567	142/263 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
HGNC	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1104340at2759
OrthoFinder	1	1.000	-	-		FOG0001059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920