Protein Alignment GRK7 and Grk6

DIOPT Version :10

• Sequence 1: NP_631948.1
• Gene: GRK7 / 131890
• HGNCID: 17031
• Length: 553
• Species: Homo sapiens
• Sequence 2: NP_113845.2
• Gene: Grk6 / 59076
• RGDID: 61986
• Length: 589
• Species: Rattus norvegicus
• Alignment Length: 534
• Identity: 244/534 - (45%)
• Similarity: 352/534 - (65%)
• Gaps: 20/534 - (3%)

Human     7 LDNLIANTAYLQARKPSDCDSKELQRR-RRSLALPGLQGCAELRQKLSLNFHSLCEQQPIGRRLF 70
            |:|::|||..|:||:....:.|...:: |:.|..|.:..|.|||..|..::|||||:|||||.||
  Rat     3 LENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERQPIGRLLF 67

Human    71 RDFLATVPTFRKAATFLEDVQNWELAEEGPTKDSA---LQGLVATCASAPAPGNPQPFLSQAVAT 132
            |:|.||.|...:...||:.|..:|:..:...|...   :|..::.......|..|:..:|.....
  Rat    68 REFCATRPELTRCTAFLDGVAEYEVTPDEKRKACGRRLMQNFLSHTGPDLIPEVPRQLVSNCAQR 132

Human   133 ----KCQAATTEEERVAAVTLAKAEAMAFLQEQPFKDFVTSAFYDKFLQWKLFEMQPVSDKYFTE 193
                .|:....|..|:....|:.|         ||.|::.|.::::|||||..|.|||:...|.:
  Rat   133 LEQGPCKDLFQELTRLTHEYLSMA---------PFADYLDSIYFNRFLQWKWLERQPVTKNTFRQ 188

Human   194 FRVLGKGGFGEVCAVQVKNTGKMYACKKLDKKRLKKKGGEKMALLEKEILEKVSSPFIVSLAYAF 258
            :|||||||||||||.||:.||||||||||:|||:||:.||.|||.||:|||||:|.|:||||||:
  Rat   189 YRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAY 253

Human   259 ESKTHLCLVMSLMNGGDLKFHIYNVGTRGLDMSRVIFYSAQIACGMLHLHELGIVYRDMKPENVL 323
            |:|..||||::||||||||||||::|..|...:|.:||:|:|.||:..||...|||||:||||:|
  Rat   254 ETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENIL 318

Human   324 LDDLGNCRLSDLGLAVEMKGGKPITQRAGTNGYMAPEILMEKVSYSYPVDWFAMGCSIYEMVAGR 388
            |||.|:.|:|||||||.:..|:.|..|.||.||||||::..: .|::..||:|:||.:|||:||:
  Rat   319 LDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNE-RYTFSPDWWALGCLLYEMIAGQ 382

Human   389 TPFKDYKEKVSKEDLKQRTLQDEVKFQHDNFTEEAKDICRLFLAKKPEQRLGSR-EKSDDPRKHH 452
            :||:..|:|:.:|:: :|.:::..:...|.|:.:|:.:|...|.|.|.:|||.| ..:.:.::|.
  Rat   383 SPFQQRKKKIKREEV-ERLVKEVAEEYTDRFSPQARSLCSQLLNKDPAERLGCRGGGAREVKEHP 446

Human   453 FFKTINFPRLEAGLIEPPFVPDPSVVYAKDIAEIDDFSEVRGVEFDDKDKQFFKNFATGAVPIAW 517
            .||.:||.||.||::||||.|||..:|.||:.:|:.||.|:||:.:..|:.|::.||||:|.|.|
  Rat   447 LFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDIEQFSTVKGVDLEPTDQDFYQKFATGSVSIPW 511

Human   518 QEEIIETGLFEELN 531
            |.|::||..|:|||
  Rat   512 QNEMVETECFQELN 525

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRK7	NP_631948.1	RGS_GRK7	40..181	CDD:188703	46/147 (31%)
		STKc_GRK7	188..474	CDD:270758	154/286 (54%)
Grk6	NP_113845.2	N-terminal	1..185		61/190 (32%)
		RGS	35..179	CDD:470619	47/152 (31%)
		STKc_GRK6	185..469	CDD:270779	155/285 (54%)