DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dcc and fra

DIOPT Version :10

Sequence 1:NP_031857.2 Gene:Dcc / 13176 MGIID:94869 Length:1447 Species:Mus musculus
Sequence 2:NP_523716.2 Gene:fra / 36377 FlyBaseID:FBgn0011592 Length:1526 Species:Drosophila melanogaster


Alignment Length:1685 Identity:487/1685 - (28%)
Similarity:732/1685 - (43%) Gaps:431/1685 - (25%)


- Green bases have known domain annotations that are detailed below.


Mouse    13 LAFVLFGASLLSAHLQVTGFQIKPFTSLHFVSEPSDAVTMRGGNVLLNCS--------AESDRGV 69
            |.|.|.|:||.|             .:|.|..||.|||...|.:|||.|:        .:|...:
  Fly    21 LIFQLIGSSLAS-------------QALSFTLEPQDAVVPEGHSVLLQCAGTASIGRGGKSKSNL 72

Mouse    70 P---VIKWK-KDGLILALGMDDRKQQLPNGSLLIQNILHSRHHKPDEGLYQCEASLADSGSIISR 130
            |   .|:|: .||..|.:..|..:.||.||||.|.::..:|..   .|.|||..:....|||:||
  Fly    73 PSSVSIRWRGPDGQDLVIVGDTFRTQLKNGSLYISSVEENRGL---TGAYQCLLTAEGVGSILSR 134

Mouse   131 TAKVTVAGPLRFLSQTESITAFM------GDTVLLKCEVIGEPMPTIHWQKN--------QQDLN 181
            .|.|.:      :.|.:....|:      |.|...:| ::||    .:||:.        :.|| 
  Fly   135 PALVAI------VRQPDLNQDFLETYLLPGQTAYFRC-MLGE----ANWQEGVKHSVQWLKDDL- 187

Mouse   182 PLPGDS-RVVVLPSGALQISRLQPGDSGVYRCSARNPASIRTGNEAEVRIL--SDPGLHRQL--Y 241
            |||.|. |:||||:|||:|..:.|.|.|.|:|:..:.:|.|..::..:.|.  ||||....:  .
  Fly   188 PLPLDKLRMVVLPNGALEIDEVGPSDRGSYQCNVTSGSSSRLSSKTNLNIKKPSDPGAENSVAPS 252

Mouse   242 FLQRPSNVIAIEGKDAVLECCVSGYPPPSFTWLRGEEVIQLR--SKKYSLLGGSNLLISNVTDDD 304
            ||..||.....||....|:|..:|.|.|...|||....:...  ..::|::|..:|.||:..|.|
  Fly   253 FLVGPSPKTVREGDTVTLDCVANGVPKPQIKWLRNGMDLDFNDLDSRFSIVGTGSLQISSAEDID 317

Mouse   305 SGTYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYAYESMDIEFECAVSGKPVPTVNWMKNGD 369
            ||.|.|..:...:::.|.|.:.|..||.|:..|.:..|:|..:.|.:|.:.|||.|.:.|:||||
  Fly   318 SGNYQCRASNTVDSLDAQATVQVQEPPKFIKAPKDTTAHEKDEPELKCDIWGKPKPVIRWLKNGD 382

Mouse   370 VVIPSDYFQIVGGSNLRILGVVKSDEGFYQCVAENEAGNAQSSAQL-IVPK-------------- 419
            ::.|:||.|:|.|.||:|||::.||.|.:|||..|.||:..::|:| :||:              
  Fly   383 LITPNDYMQLVDGHNLKILGLLNSDAGMFQCVGTNAAGSVHAAARLRVVPQGVKIKKRKSQGHST 447

Mouse   420 ----------------------------------------------------------------- 419
                                                                             
  Fly   448 KSLQTFDNLTKRRKPFNSGEQLRTKSGGSFPFPDEDDDLDDNDSGTTRLRIPSGKLPKFEQPLND 512

Mouse   420 ----------------------------------------------------------------- 419
                                                                             
  Fly   513 RRFNILNAGSALPLDNQSKSYEDDDDDYDEDDPAKEALLEAYKQGEDAHKILDSWQQSKSKKSQQ 577

Mouse   420 ----PAIPSS--------------------SILPSAPRDVLPVLVSSRFVRLSWRPPAEAKGNIQ 460
                ||.|.|                    :.|||.|||::..:|.||||.|||..|.:..|::.
  Fly   578 QKQSPASPDSPEQDPSVPHPGGKPLDSGLQARLPSQPRDLVAQIVKSRFVTLSWVEPLQNAGDVV 642

Mouse   461 TFTVFFSREGDNRERALNTTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPEL 525
            .:||::......||:.:.|......|:.:.:|.|...|.|||.|...:|.|.||.|::|:||||:
  Fly   643 YYTVYYKMNNSEREQKMVTKSHDDQQVNIQSLLPGRTYQFRVEANTNFGSGASSAPLEVSTQPEV 707

Mouse   526 QVPGPVENLHAVSTSPTSILITWEPPAYANGPVQGYRLFCTEVSTGKEQNIEVDGLSYKLEGLKK 590
            .:.||..|....:.|...|.:.||.|...||.:..||::.:|..:|.:...:...|...|..|:.
  Fly   708 NIAGPPRNFEGYARSHKEIYVKWEEPTVTNGEILKYRVYYSENDSGADLYHDSTALEAVLTELRP 772

Mouse   591 FTEYTLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNISLEVVNSRSIKVSWLPPPSGTQNGFI 655
            .|:|.:..:.:||.|.|.|:.:|.|.|.|..||.||.|::|||.:|.||.|.|.||....:||.|
  Fly   773 HTDYVISVVPFNRNGMGDSSAEIRVKTFSSTPSEPPNNVTLEVTSSSSITVHWEPPAEEDRNGQI 837

Mouse   656 TGYKIRHRKTTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDL 720
            ||||||:||.....::::...|..::..:.|::.::|..:::||||||:||.:.|..|.|.||||
  Fly   838 TGYKIRYRKFKDAPQVKSTPANIRYFELSNLDRNAEYQVKIAAMTVNGSGPFTEWNRANTLENDL 902

Mouse   721 DESQVPDQPSSLHVRPQTNCIIMSWTPPLNPNIVVRGYIIGYGVGSPYAETVRVDSKQRYYSIER 785
            ||:|||.:|..:.:.|..|.|.:.|.||.:|.|.:|.|::|:|.|.|...|:.:...:||:.::.
  Fly   903 DETQVPGKPIWISIHPGANNIALHWGPPQHPEIKIRNYVLGWGRGIPDENTIELKETERYHILKN 967

Mouse   786 LESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSGPDVSTPMLPPVGV 850
            |||:..||:||:|.|..|:|.|:|::..||               |:.|...|   ||:..|||:
  Fly   968 LESNMDYVVSLRARNVKGDGPPIYDNIKTR---------------DEEPVDAP---TPLEVPVGL 1014

Mouse   851 QAVALTHEAVRVSWADNSVPKNQKTSDVRLYTVRWRTSFSASAKYKSEDTTSLSYTATGLKPNTM 915
            :|:.::..::.|.|.|..:.|||..:|.|.|||.:  ..:.|.:|:..:||.|:.....|:|||.
  Fly  1015 RAITMSSSSIVVYWIDTMLNKNQHVTDNRHYTVSY--GITGSNRYRYHNTTDLNCMINDLRPNTQ 1077

Mouse   916 YEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKPRAVIVSWQPPLEANGKITAY 980
            |||:|.|.|.||.|:|||:...:||:..|.:.|:::||...|..|..|||.|.||....|:||.|
  Fly  1078 YEFAVKVVKGRRESSWSMSVLNSTYQNVPVTPPREVTVRLDEMNPPTVIVQWIPPKHTLGQITGY 1142

Mouse   981 ILFYTLDKNIPIDDWIMETISGDRLTHQIMDLSLDTMYYFRIQARNVKGV--GPLSDPILFRT-- 1041
            .::||.|......||.:|..:|:.....:.:|...|.|||::|||..||.  .|.|..:.:.|  
  Fly  1143 NIYYTTDTTKRDRDWSVEAFAGEETMLMLPNLKPYTTYYFKVQARTTKGANNAPFSALVSYTTSA 1207

Mouse  1042 -LKVEHPDKMANDQGRHGDGGYWPVDTNLIDRSTLNEPPIGQMHPPHGSVTPQKNSNLLVITVVT 1105
             :.::.||.:|..                ||                       |..||.|.:..
  Fly  1208 AVTMQEPDTIAKG----------------ID-----------------------NEKLLYIIIAA 1233

Mouse  1106 VGVLTVLVVVIVAVICTRR--SSAQQRKKRATHSVSKRKGSQKDLRPPDLWIHHEEMEMKNIEKP 1168
            ..|:.::|::.|.::|.|:  ||.:..||      |.:|.:....:||||||||::||:|||:|.
  Fly  1234 TAVVLLVVLLGVLLLCRRKPQSSPEHTKK------SYQKNNVGVPKPPDLWIHHDQMELKNIDKG 1292

Mouse  1169 TGTDPAGRDSPIQSCQDLTPVSHSQSETQMGSKSASHSGQDTEDAGSSMSTLERSLAARRATRAK 1233
            ..|              :|||.         |..||.||                         .
  Fly  1293 LHT--------------VTPVC---------SDGASSSG-------------------------A 1309

Mouse  1234 LMIPMEAQSSNPAVVSAIP---VPTLESAQY-PGILPSPTCG------YPHPQFTLRPVPFPTLS 1288
            |.:|.....|...|.:.:|   ..:|:...| ||.:.:...|      ||..|::.:.....|:.
  Fly  1310 LTLPRSVVHSEYEVETPVPGHVTNSLDKRSYVPGYMTTSMNGTMERPQYPRTQYSHQNRSHMTME 1374

Mouse  1289 VDRGFGAGRTQSVSEGPTTQQQPMLPPAQPEHPSSE------EAPSRTIPTACV------RPTHP 1341
                  ||    :|:...||.|.......||||...      .|.:......||      :..||
  Fly  1375 ------AG----LSQQSLTQPQSNSMAQTPEHPYGGYDANFCNAGNAAAGNGCVSTIESSKRGHP 1429

Mouse  1342 LRSFANPLLPPPMSAIEPKVPYTPLLS-QPGPTLPKTHVKTASLGLAGKARSPLLPVSVPT---- 1401
            |:||:.| .|||.....|...:||.:: :|....|              .:.|....:.|.    
  Fly  1430 LKSFSVP-GPPPTGGATPVTKHTPAVTIRPQNQSP--------------YKKPSFSAATPNRLQG 1479

Mouse  1402 --------------APEVSEESHKPTEDPASVYEQDDLSEQMASLEGLMKQLNAITGSAF 1447
                          ||..|.|               :|:::||:||||||.|:|||.:.|
  Fly  1480 GGSVVHSTDEIQRLAPSTSTE---------------ELNQEMANLEGLMKDLSAITANEF 1524

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DccNP_031857.2 IgI_1_Neogenin_like 39..136 CDD:409387 39/108 (36%)
Ig strand A 39..42 CDD:409387 1/2 (50%)
Ig strand A' 45..51 CDD:409387 4/5 (80%)
Ig strand B 55..65 CDD:409387 4/17 (24%)
Ig strand C 70..76 CDD:409387 3/9 (33%)
Ig strand C' 78..81 CDD:409387 1/2 (50%)
Ig strand D 88..93 CDD:409387 1/4 (25%)
Ig strand E 95..101 CDD:409387 4/5 (80%)
Ig strand F 113..120 CDD:409387 4/6 (67%)
Ig strand G 125..136 CDD:409387 7/10 (70%)
Ig_3 139..216 CDD:464046 29/91 (32%)
I-set 241..327 CDD:400151 27/87 (31%)
Ig strand B 257..261 CDD:409353 1/3 (33%)
Ig strand C 270..274 CDD:409353 0/3 (0%)
Ig strand E 293..297 CDD:409353 1/3 (33%)
Ig strand F 307..312 CDD:409353 2/4 (50%)
Ig strand G 322..325 CDD:409353 1/2 (50%)
IgI_4_Neogenin_like 334..417 CDD:409388 36/83 (43%)
Ig strand A 334..337 CDD:409388 0/2 (0%)
Ig strand A' 339..343 CDD:409388 0/3 (0%)
Ig strand B 346..355 CDD:409388 2/8 (25%)
Ig strand C 360..366 CDD:409388 2/5 (40%)
Ig strand C' 368..371 CDD:409388 2/2 (100%)
Ig strand D 376..380 CDD:409388 2/3 (67%)
Ig strand E 384..388 CDD:409388 2/3 (67%)
Ig strand F 396..404 CDD:409388 4/7 (57%)
Ig strand G 407..417 CDD:409388 3/10 (30%)
FN3 429..521 CDD:238020 34/91 (37%)
FN3 <478..901 CDD:442628 151/422 (36%)
FN3 946..1041 CDD:238020 34/96 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1126..1153 7/26 (27%)
Neogenin_C 1148..1445 CDD:461954 83/337 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1166..1220 10/53 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1291..1329 11/43 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1394..1419 5/42 (12%)
fraNP_523716.2 Ig 34..140 CDD:472250 39/108 (36%)
Ig strand B 52..56 CDD:409387 3/3 (100%)
Ig strand C 77..81 CDD:409387 1/3 (33%)
Ig strand E 102..106 CDD:409387 3/3 (100%)
Ig strand F 118..123 CDD:409387 3/4 (75%)
Ig strand G 133..136 CDD:409387 2/2 (100%)
Ig <178..222 CDD:472250 20/44 (45%)
Ig strand C 179..183 CDD:409550 0/3 (0%)
Ig strand E 202..206 CDD:409550 3/3 (100%)
Ig strand F 216..221 CDD:409550 2/4 (50%)
Ig_3 251..327 CDD:464046 25/75 (33%)
Ig 347..428 CDD:472250 35/80 (44%)
Ig strand B 361..365 CDD:409388 1/3 (33%)
Ig strand C 374..378 CDD:409388 0/3 (0%)
Ig strand E 396..400 CDD:409388 2/3 (67%)
Ig strand F 410..415 CDD:409388 2/4 (50%)
Ig strand G 423..426 CDD:409388 0/2 (0%)
FN3 611..703 CDD:238020 34/91 (37%)
FN3 <676..1068 CDD:442628 151/411 (37%)
FN3 1109..1205 CDD:238020 34/95 (36%)
Neogenin_C 1273..1521 CDD:461954 82/335 (24%)

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