DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SLC31A1 and Ctr1A

DIOPT Version :9

Sequence 1:	NP_001850.1	Gene:	SLC31A1 / 1317	HGNCID:	11016	Length:	190	Species:	Homo sapiens
Sequence 2:	NP_001245552.1	Gene:	Ctr1A / 31601	FlyBaseID:	FBgn0062413	Length:	241	Species:	Drosophila melanogaster

Alignment Length:	248	Identity:	99/248 - (39%)
Similarity:	128/248 - (51%)	Gaps:	65/248 - (26%)

- Green bases have known domain annotations that are detailed below.

Human     1 MDHSH-------------HMGM------------SYMDS---------NSTMQPSHHHPTTSASH 31
            |||:|             |:||            |.||:         .|.:|.||.......:|
  Fly     1 MDHAHHSAPGVDHSMHHDHVGMHHDHSGIPAATASPMDAASMFDLIPDTSDLQASHAGHAAHGAH 65

Human    32 SHGGGDSSMM--MMPMTFYFGFKNVELLFSGLVINTAGEMAGAFVAVFLLAMFYEGLKIARESLL 94
            :||||..:.|  ||||.|:||: |..:|||...|.|...:.|:.:|:||||:.|||||..||.|.
  Fly    66 NHGGGSGTGMEHMMPMAFHFGY-NETILFSWWHIETVAGLIGSMIAIFLLALMYEGLKYYREYLF 129

Human    95 RKSQVSIRYNSMPVPGPN----------------------GTILMETHKTVGQQMLSFPHLLQTV 137
            .|:...:.|.  ||.||.                      |.::   ||. ...|||..|||||:
  Fly   130 WKTYNLLEYR--PVTGPQRNPEAPRIPSPAAAAPSPVQYVGEVV---HKQ-PPSMLSINHLLQTL 188

Human   138 LHIIQVVISYFLMLIFMTYNGYLCIAVAAGAGTGYFLFSWKKAVVVDITEHCH 190
            ||::||.:|:.|||||||||.:||:.|..||..|||||.|||:|:||:|||||
  Fly   189 LHVLQVTLSFLLMLIFMTYNVWLCLMVVLGAAVGYFLFCWKKSVIVDVTEHCH 241

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC31A1	NP_001850.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..35		16/67 (24%)
SLC31A1	NP_001850.1	Ctr	45..175	CDD:398012	63/151 (42%)
Ctr1A	NP_001245552.1	Ctr	79..226	CDD:282057	65/153 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	106	1.000	Domainoid score	I6604
eggNOG	1	0.900	-	-		E1_KOG3386
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1399
Inparanoid	1	1.050	157	1.000	Inparanoid score	I4297
Isobase	1	0.950	-	0	Normalized mean entropy	S2329
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1389393at2759
OrthoFinder	1	1.000	-	-		FOG0000938
OrthoInspector	1	1.000	-	-		oto88750
orthoMCL	1	0.900	-	-		OOG6_102787
Panther	1	1.100	-	-	LDO	PTHR12483
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4018
SonicParanoid	1	1.000	-	-		X3487
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.810