Protein Alignment Slc6a3 and ine

DIOPT Version :9

• Sequence 1: NP_034150.1
• Gene: Slc6a3 / 13162
• MGIID: 94862
• Length: 619
• Species: Mus musculus
• Sequence 2: NP_001162871.1
• Gene: ine / 33659
• FlyBaseID: FBgn0011603
• Length: 943
• Species: Drosophila melanogaster
• Alignment Length: 581
• Identity: 231/581 - (39%)
• Similarity: 360/581 - (61%)
• Gaps: 41/581 - (7%)

Mouse    47 LINPPQTP------------------VEVQERET-WSKKIDFLLSVIGFAVDLANVWRFPYLCYK 92
            ::| ||||                  .:::.|:. |:.|:.|:|:.||::|.|.|||||||:|||
  Fly   306 MVN-PQTPPPLGVDDDDSYLDMSDETAQLKPRQQHWANKMQFVLACIGYSVGLGNVWRFPYMCYK 369

Mouse    93 NGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAG-VWKICPVLKGVGFTVILISFYVGFFY 156
            :|||.|||||.:.:.|..:||.:|||::||:...|..| :.::||:.||.|...:::||.:..:|
  Fly   370 SGGGVFLVPYCIILFICSIPLLFMELSVGQYTGRGPIGALGQLCPLFKGAGLASVVVSFLMSTYY 434

Mouse   157 NVIIAWALHYFFSSFTMDLPWIHCNNTWNSPNCSDAHSSNSSDGLGLN----DTFGTTPAAEYFE 217
            :|||.::::|||:||..::|||.|||.||:|:|......      |:|    || ..||:.|:||
  Fly   435 SVIIGYSIYYFFTSFKTEMPWIDCNNRWNTPDCWVPQRK------GINASAPDT-SRTPSEEFFE 492

Mouse   218 RGVLHLHQSRGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLR 282
            ..||.:  |.|::..|..||:|.|||:...:::||:.||.:|:|.||.:.|||.|:|::..|::|
  Fly   493 NKVLQI--SGGLEYPGMMRWELFACLICAWLMVYFATWKSIKSSAKVRYFTATFPFVLIIILMVR 555

Mouse   283 GVTLPGAMDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAII 347
            .|||.||.:|:|.:....:..|..|:|||:||:|...|||:.||.:|:|:||||:.||..||.:.
  Fly   556 AVTLDGAAEGLRFFFRPKWSELKNANVWINAASQNFNSLGITFGSMISFASYNKYNNNILRDTVA 620

Mouse   348 TTSINSLTSFSSGFVVFSFLGYMAQKHNVPIRDVATDGPGLIFIIYPEAIATLPLSSAWAAVFFL 412
            .:::|.:||...|...||.||.:|.:.|..:|||..||||:||::||:|:|.:|.:..||.:||.
  Fly   621 VSAVNMITSLLVGIFAFSTLGNLALEQNTNVRDVIGDGPGMIFVVYPQAMAKMPYAQLWAVMFFF 685

Mouse   413 MLLTLGIDSAMGGMESVITGLVDEF-QLLHRH---RELFTLGIVLATFLLSLFCVTNGGIYVFTL 473
            |||.||::|....:|.|:|.:.|.| :.:.||   .|:..|.:.:.:.|..:..:..||||.|.|
  Fly   686 MLLCLGLNSQFAIVEVVVTSIQDGFPRWIKRHLGYHEIVVLFVCVISCLFGMPNIIQGGIYYFQL 750

Mouse   474 LDHFAAGTSILFGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVVS 538
            :||:||..:|:|....:.|.:|||||..:.|.::|||||:.|:.|.|.||.::.||.|..:.|:|
  Fly   751 MDHYAASVTIMFLAFCQMIAIAWFYGTGRLSKNVKQMTGKAPSFYLRSCWLVLGPCLLFAIWVLS 815

Mouse   539 IVTFRPP--HYGAYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPG-SFREKLAYAITP 596
            ::.:..|  |.|.|.:||||..:||:.|:.|:..:|.||...|....| :|.|::...:.|
  Fly   816 LINYHEPTYHNGRYTYPDWAYGIGWMFASFSLICIPGYAVINFLRSSGDTFWERIRNTLRP 876

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Slc6a3	NP_034150.1	SLC5-6-like_sbd	60..613	CDD:294310	226/550 (41%)
		Interaction with TGFB1I1. /evidence=ECO:0000250	560..589		10/29 (34%)
ine	NP_001162871.1	SLC5-6-like_sbd	337..876	CDD:294310	224/547 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820