DRSC/TRiP Functional Genomics Resources

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Protein Alignment LRRC15 and Fili

DIOPT Version :9

Sequence 1:NP_001128529.2 Gene:LRRC15 / 131578 HGNCID:20818 Length:587 Species:Homo sapiens
Sequence 2:NP_001369108.1 Gene:Fili / 5740472 FlyBaseID:FBgn0085397 Length:789 Species:Drosophila melanogaster


Alignment Length:573 Identity:142/573 - (24%)
Similarity:230/573 - (40%) Gaps:105/573 - (18%)


- Green bases have known domain annotations that are detailed below.


Human    31 CPSECTC---SRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELN-ESPFLNISALIALRIE 91
            |||:|.|   ...|:..|..|.:..||                 .:|| |:.::|   |...||.
  Fly    42 CPSKCQCLGGEANSRALCVDAALEDVP-----------------IQLNPETKYIN---LTVNRIR 86

Human    92 KNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSN 156
            ..|.|  .|...:    |..|.|:.|.::.|....|:....|.:|.||.|.:..:....|...:|
  Fly    87 TLEFS--LPFYMK----LEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAFKGLTN 145

Human   157 LKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMG 221
            |..|.|..|.:|.:...|...|..|.:|:|..|::..:....|:.:..|:||....|||.|:|..
  Fly   146 LLLLDLSFNRIETVHPTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRNNRLLDVPAS 210

Human   222 TFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSVFMQLPQLNRLTLFGNS 286
                  ||..|                  |.|:.|.:|.|.:..:....|..|.:|..|::.||.
  Fly   211 ------NLWHL------------------HALKSLDMSLNLVEFVRNDSFEGLKELLALSVQGNV 251

Human   287 LKELSPGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRE 351
            :.||....|..:.:|:.|.|.||:::.:|....|.|..|..|.|..|:.|.:...||..|..|||
  Fly   252 MSELDLSAFEGLISLKHLDLSDNNLTMVPTQQLSKLSNLTYLNLGGNRFSQLPAVAFLNLFHLRE 316

Human   352 LSL-HTNALQDLDGNVFRMLANLQNISLQNN-RLRQLPGNIFANVNGLMAIQLQNNQLENLPLGI 414
            |.| ..:.||.:|...|....:||.:.|.|| :|..:|..:|.....::.:.:|:|.|:.|....
  Fly   317 LHLSRLDFLQRIDSRAFVDNTHLQTLHLNNNPQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQ 381

Human   415 FDHLGKLCELRLYDNPWRCDSDILPLRNWLLL--------------------------NQPRLGT 453
            |. :.:|.:|.|.|||.:|:..:|.|  |.|:                          :...|..
  Fly   382 FP-VDQLQKLYLGDNPLQCNCSLLWL--WRLVTGNFEGVDPGMEHAAGGAVAALAKEADDEELAD 443

Human   454 DTVPVCFSPANVRGQSLIIINVNVAVPSVHVPEVPSYPETPWYPDTPSYPDTTSVSSTTELTSPV 518
            :...|..:...|...:..|...:: |.::|..| ||           :|...||.|:.......:
  Fly   444 EATAVASTDDGVAALAAYIAEQHI-VNALHTTE-PS-----------AYELATSSSNRNSGILRM 495

Human   519 EDY---TDLTTIQVTDDRSVWGMTQAQSGLAIAAIVIGIV--ALACSLAACVG 566
            :..   .|:...:|...|.:  :|.::..:...|.::.:|  .:.|.|.|.:|
  Fly   496 DRQQIGCDIWRDKVRTRRKL--LTMSEGEITCPAHIVTVVCAVITCLLVAMIG 546

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRRC15NP_001128529.2 LRR_8 60..119 CDD:290566 14/59 (24%)
LRR_RI 63..309 CDD:238064 63/246 (26%)
LRR_8 88..167 CDD:290566 22/78 (28%)
leucine-rich repeat 88..108 CDD:275380 5/19 (26%)
leucine-rich repeat 109..156 CDD:275380 12/46 (26%)
leucine-rich repeat 157..180 CDD:275380 7/22 (32%)
LRR_8 180..239 CDD:290566 16/58 (28%)
leucine-rich repeat 181..204 CDD:275380 5/22 (23%)
leucine-rich repeat 205..228 CDD:275380 8/22 (36%)
LRR_8 228..287 CDD:290566 14/58 (24%)
leucine-rich repeat 229..252 CDD:275380 2/22 (9%)
leucine-rich repeat 253..276 CDD:275380 6/22 (27%)
leucine-rich repeat 277..300 CDD:275380 7/22 (32%)
LRR_8 299..359 CDD:290566 21/60 (35%)
LRR_4 299..340 CDD:289563 13/40 (33%)
leucine-rich repeat 301..324 CDD:275380 8/22 (36%)
LRR_4 324..364 CDD:289563 15/40 (38%)
leucine-rich repeat 325..348 CDD:275380 8/22 (36%)
leucine-rich repeat 349..370 CDD:275380 9/21 (43%)
LRR_8 372..430 CDD:290566 17/58 (29%)
leucine-rich repeat 373..393 CDD:275380 8/20 (40%)
leucine-rich repeat 397..418 CDD:275380 5/20 (25%)
TPKR_C2 429..>468 CDD:301599 10/64 (16%)
FiliNP_001369108.1 leucine-rich repeat 75..97 CDD:275378 7/26 (27%)
leucine-rich repeat 98..121 CDD:275380 6/22 (27%)
LRR_8 120..180 CDD:404697 18/59 (31%)
leucine-rich repeat 122..145 CDD:275380 6/22 (27%)
leucine-rich repeat 146..169 CDD:275380 7/22 (32%)
LRR <161..>354 CDD:227223 63/216 (29%)
leucine-rich repeat 170..193 CDD:275380 5/22 (23%)
leucine-rich repeat 194..217 CDD:275380 11/46 (24%)
leucine-rich repeat 218..265 CDD:275380 13/46 (28%)
leucine-rich repeat 266..289 CDD:275380 8/22 (36%)
leucine-rich repeat 290..313 CDD:275380 8/22 (36%)
leucine-rich repeat 314..338 CDD:275380 9/23 (39%)
LRR_8 337..397 CDD:404697 18/60 (30%)
leucine-rich repeat 339..360 CDD:275380 8/20 (40%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24373
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
22.010

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