Protein Alignment LRRC15 and CG7509

DIOPT Version :10

• Sequence 1: NP_001128529.2
• Gene: LRRC15 / 131578
• HGNCID: 20818
• Length: 587
• Species: Homo sapiens
• Sequence 2: NP_647931.1
• Gene: CG7509 / 38579
• FlyBaseID: FBgn0035575
• Length: 615
• Species: Drosophila melanogaster
• Alignment Length: 452
• Identity: 122/452 - (26%)
• Similarity: 199/452 - (44%)
• Gaps: 48/452 - (10%)

Human    21 AWGAGLAYHGCPS-ECTCS-RASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNIS 83
            |.|:.:.::.|.| .|.|: ......|....:.:||.             |.:..:|
  Fly   139 ATGSQIEWNHCTSGVCRCNPDTKSFTCWNTNLKSVPV-------------TQVIPMN-------- 182

Human    84 ALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQP 148
             ::.:.:.:|.||.:....||.|..|:.|.:::|.|..||..|||.||||..|.:.:|||..|..
  Fly   183 -MVNIDLSRNILSTLHKDTFRGLTVLKELDISHNVLDFLPFDLFQDLDSLLVLRIQNNQLEDIDH 246

Human   149 AHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYEN 213
            ..|.:..||..|.|..|.:..:|:..|.|...||.:|:..|.:.:..|.:.:....|:.|.:..|
  Fly   247 RTFWKLRNLNILDLSKNEIGMLPESIFYHAQRLTVINMCDNQIQNFPPNLLRDQLMLEELDMSRN 311

Human   214 RLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSVFMQLPQLN 278
            :::::..|:...|..|:.|....|||..:....|....:|:.|.|.||.||.|..::|..|..|.
  Fly   312 KISELSSGSIRYLTKLKTLDFGWNQIAKIDDDFFAGLRSLRTLSLHNNRISSLSGTIFNNLANLV 376

Human   279 RLTLFGNSLKELSPGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAF 343
            .|.|..|.:..:....|..:.||.||:|..|.:||:|.::|.|:..|..|.|..|.::.:....|
  Fly   377 TLDLTTNRISHIDGNAFVELNNLNELFLGQNSMSSIPADLFLNVSALTRLTLFSNNLTTLEADDF 441

Human   344 NGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLE 408
            .||..|:.|.|:.|.|::.|...|..|:.|:.:.:.:|:|..||......:..|:|::|..
  Fly   442 QGLNNLKILLLNNNILKNFDARAFEPLSQLEKLRIDSNKLMFLPHGALHGLKNLVAVKLDK---- 502

Human   409 NLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSL 470
                                |||.||...|.|..|:.....:|.....|:|..|.::.|..:
  Fly   503 --------------------NPWHCDCRALYLARWIREFVLKLWDGQQPMCRGPGDLGGHEV 544

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LRRC15	NP_001128529.2	LRR	50..449	CDD:443914	110/398 (28%)
		leucine-rich repeat	88..108	CDD:275380	6/19 (32%)
		leucine-rich repeat	109..156	CDD:275380	19/46 (41%)
		leucine-rich repeat	157..180	CDD:275380	7/22 (32%)
		leucine-rich repeat	181..204	CDD:275380	5/22 (23%)
		leucine-rich repeat	205..228	CDD:275380	5/22 (23%)
		leucine-rich repeat	229..252	CDD:275380	6/22 (27%)
		leucine-rich repeat	253..276	CDD:275380	10/22 (45%)
		leucine-rich repeat	277..300	CDD:275380	5/22 (23%)
		leucine-rich repeat	301..324	CDD:275380	10/22 (45%)
		leucine-rich repeat	325..348	CDD:275380	7/22 (32%)
		leucine-rich repeat	349..370	CDD:275380	7/20 (35%)
		leucine-rich repeat	373..393	CDD:275380	5/19 (26%)
		leucine-rich repeat	397..418	CDD:275380	3/20 (15%)
CG7509	NP_647931.1	LRR	185..>437	CDD:443914	79/251 (31%)
		leucine-rich repeat	187..206	CDD:275380	6/18 (33%)
		leucine-rich repeat	207..230	CDD:275380	10/22 (45%)
		leucine-rich repeat	231..254	CDD:275380	7/22 (32%)
		leucine-rich repeat	255..278	CDD:275380	7/22 (32%)
		leucine-rich repeat	279..302	CDD:275380	5/22 (23%)
		leucine-rich repeat	303..326	CDD:275380	5/22 (23%)
		leucine-rich repeat	327..350	CDD:275380	6/22 (27%)
		leucine-rich repeat	351..374	CDD:275380	10/22 (45%)
		leucine-rich repeat	375..398	CDD:275380	5/22 (23%)
		leucine-rich repeat	399..422	CDD:275380	10/22 (45%)
		leucine-rich repeat	423..443	CDD:275380	5/19 (26%)
		leucine-rich repeat	471..494	CDD:275380	5/22 (23%)
		PCC	476..>561	CDD:188093	20/93 (22%)