Protein Alignment LRRC15 and lbk

DIOPT Version :10

• Sequence 1: NP_001128529.2
• Gene: LRRC15 / 131578
• HGNCID: 20818
• Length: 587
• Species: Homo sapiens
• Sequence 2: NP_611091.2
• Gene: lbk / 36788
• FlyBaseID: FBgn0034083
• Length: 1252
• Species: Drosophila melanogaster
• Alignment Length: 505
• Identity: 137/505 - (27%)
• Similarity: 230/505 - (45%)
• Gaps: 35/505 - (6%)

Human    31 CPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIAL-RIE-KN 93
            ||.:|.|... ..:|....:..||. ||....:|.:.|   .:||::..|.|..|:.| ::. |.
  Fly   265 CPKDCKCLNV-LFDCDKLHLERVPV-LPSYVQTLHLAN---NKLNDTTVLEIRNLLNLTKVSLKR 324

Human    94 ELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLK 158
            .|..:.| .|..|..|::|.||||.:..:.......|..|.:|.||.|:|..|:...|.:.:||.
  Fly   325 NLLEVIP-KFIGLSGLKHLVLANNHITSISSESLAALPLLRTLDLSRNKLHTIELNSFPKSNNLV 388

Human   159 ELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTF 223
            .|.|..|.:..:.:.:|..|..||.|.|..|.|:.:..|||::|..|:.|.|..|:| :|...||
  Fly   389 HLILSFNEITNVNEHSFATLNNLTDLELSNNRLSTLPIRVFKNLNQLKKLALNFNQL-EINWSTF 452

Human   224 DGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSVFMQLPQLNRLTLFGNSLK 288
            .||.:::.|.|:.|:|..|..|:|:..|.::.:.|:.|.||.|.......|.:|..|.|..|::.
  Fly   453 RGLESMKNLQLKSNKIRALQDGVFYVMHKIETIDLAMNQISSLSRQGLFNLTKLRHLNLSFNAIS 517

Human   289 ELSPGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELS 353
            .:....:....:|..|.|.:|.|:.........|.:|:.|.|:.|::.::....|:.:..|.||:
  Fly   518 RIEVDTWEFTQSLEVLDLSNNAINEFKPQHLDCLHRLKTLNLAHNRLQYLQENTFDCVKNLEELN 582

Human   354 LHTNAL----QDLDGNV-FRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLG 413
            |..|.|    :|..... |:.|..|:.:.|..|.|:|:.....:.:|.|..:.|.:|.|.::.:.
  Fly   583 LRRNRLSWIIEDQSAAAPFKGLRKLRRLDLHGNNLKQISTKAMSGLNNLEILNLGSNALASIQVN 647

Human   414 IFDHLGKLCELRLYDNPWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSLIIINVNVA 478
            .|:|:.:|.:|......:.||.|::..:.||....|:.....  ||..|.::..:.|..::.:..
  Fly   648 AFEHMLRLNKLVFKSLNFICDCDLVWFQQWLKNRFPQQAEHA--VCGYPEHLLDRHLKSLSSSEL 710

Human   479 VPSVHVPEVPSYPETPWYPD--------------TPSYPDTTSVSSTTEL 514
            | .|..|:    |.....||              ..|.|...|:::..||
  Fly   711 V-CVDSPK----PRVEQEPDDMLAVNAANITLECIASSPTAASLAAADEL 755

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LRRC15	NP_001128529.2	LRR	50..449	CDD:443914	116/405 (29%)
		leucine-rich repeat	88..108	CDD:275380	6/21 (29%)
		leucine-rich repeat	109..156	CDD:275380	15/46 (33%)
		leucine-rich repeat	157..180	CDD:275380	6/22 (27%)
		leucine-rich repeat	181..204	CDD:275380	10/22 (45%)
		leucine-rich repeat	205..228	CDD:275380	10/22 (45%)
		leucine-rich repeat	229..252	CDD:275380	7/22 (32%)
		leucine-rich repeat	253..276	CDD:275380	6/22 (27%)
		leucine-rich repeat	277..300	CDD:275380	4/22 (18%)
		leucine-rich repeat	301..324	CDD:275380	6/22 (27%)
		leucine-rich repeat	325..348	CDD:275380	5/22 (23%)
		leucine-rich repeat	349..370	CDD:275380	8/25 (32%)
		leucine-rich repeat	373..393	CDD:275380	5/19 (26%)
		leucine-rich repeat	397..418	CDD:275380	5/20 (25%)
lbk	NP_611091.2	LRR	<293..642	CDD:443914	102/353 (29%)
		leucine-rich repeat	293..316	CDD:275380	7/25 (28%)
		leucine-rich repeat	317..338	CDD:275380	6/21 (29%)
		leucine-rich repeat	339..362	CDD:275380	7/22 (32%)
		leucine-rich repeat	363..386	CDD:275380	8/22 (36%)
		leucine-rich repeat	387..410	CDD:275380	6/22 (27%)
		leucine-rich repeat	411..434	CDD:275380	10/22 (45%)
		leucine-rich repeat	435..457	CDD:275380	10/22 (45%)
		leucine-rich repeat	458..481	CDD:275380	7/22 (32%)
		leucine-rich repeat	482..505	CDD:275380	6/22 (27%)
		leucine-rich repeat	506..529	CDD:275380	4/22 (18%)
		leucine-rich repeat	530..553	CDD:275380	6/22 (27%)
		leucine-rich repeat	554..577	CDD:275380	5/22 (23%)
		leucine-rich repeat	578..604	CDD:275380	8/25 (32%)
		leucine-rich repeat	607..630	CDD:275380	5/22 (23%)
		leucine-rich repeat	631..652	CDD:275380	5/20 (25%)
		LRRCT	665..712	CDD:214507	11/49 (22%)
		Ig_3	717..816	CDD:464046	8/43 (19%)
		Ig	835..924	CDD:472250
		Ig strand B	851..855	CDD:409353
		Ig strand C	864..868	CDD:409353
		Ig strand E	890..894	CDD:409353
		Ig strand F	904..909	CDD:409353
		Ig strand G	917..920	CDD:409353
		Ig_3	927..1013	CDD:464046