Protein Alignment LRRC15 and CG4168

DIOPT Version :10

• Sequence 1: NP_001128529.2
• Gene: LRRC15 / 131578
• HGNCID: 20818
• Length: 587
• Species: Homo sapiens
• Sequence 2: NP_609740.4
• Gene: CG4168 / 34889
• FlyBaseID: FBgn0028888
• Length: 1330
• Species: Drosophila melanogaster
• Alignment Length: 395
• Identity: 124/395 - (31%)
• Similarity: 198/395 - (50%)
• Gaps: 38/395 - (9%)

Human    63 SLQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNL-GSLRYLSLANNKLQVLPIGL 126
            :|.:....:|:|.|:.| ..:.:..|.:..|.:||:.|.||..| .:|.||.|..|:|..:|:.|
  Fly   368 ALNLEQNFVTQLPEAVF-KATGIAHLVLAFNAISRVHPSAFEGLTETLEYLDLERNRLTTVPVAL 431

Human   127 FQGLDSLESLLLSSNQLLQIQ--PAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKN 189
             ..|..|:.|.|:|||:.|:.  |: |::  ||:.|.|.||:...||.....:...|:.||:|.|
  Fly   432 -SSLHHLKYLYLTSNQISQLNNLPS-FTE--NLRVLSLSGNNFSMIPVLGLKNYTQLSYLNMGYN 492

Human   190 SLTHISPRVF---QHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHN-N 250
            |:|.|...:|   ....|||.:.|..|::|.:.:|:|.||..:||::|..|.|.:..|.:|.| :
  Fly   493 SITDIPEGIFAVDSWGSNLQTILLRNNKITHLHLGSFAGLEQIQEISLSFNDITIHHPLVFENVS 557

Human   251 HNLQRLYLSNNHISQLPPSVFMQLPQLNRLTLFGNSLKELSP-GIFGPMPNLRELWLYDNHISSL 314
            ..|:.|.||           |...|        ..||:.|.| ....|:..|..|.|.:|::..:
  Fly   558 RTLKILELS-----------FAVFP--------ARSLESLDPLDALLPLSQLIWLGLDNNNLKQV 603

Human   315 PDNVFSNLRQLQVLILSRNQISFISPGAF--NGLTELRELSLHTNALQDLDGNVFRMLANLQNIS 377
            .:..|:.:|:|..:.||.||:..:..|.|  :..:.|.|:.|..|.|:.|:...|..|.:||.::
  Fly   604 SNESFAQMRELSYINLSFNQLKTLPRGLFQSDAHSHLVEIDLSYNGLERLEAQTFHSLGDLQTLN 668

Human   378 LQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRN 442
            ||:||||.:..:.|.|:..|..:.|..|:|.|:..|.|..|..|..|.|..|. .|.   |.|::
  Fly   669 LQSNRLRTIARHAFHNLEFLRYLDLSYNRLVNISHGAFTVLPNLAALDLMHNQ-LCS---LSLKS 729

Human   443 WLLLN 447
            :|.::
  Fly   730 FLYVS 734

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LRRC15	NP_001128529.2	LRR	50..449	CDD:443914	124/395 (31%)
		leucine-rich repeat	88..108	CDD:275380	8/20 (40%)
		leucine-rich repeat	109..156	CDD:275380	18/48 (38%)
		leucine-rich repeat	157..180	CDD:275380	7/22 (32%)
		leucine-rich repeat	181..204	CDD:275380	9/25 (36%)
		leucine-rich repeat	205..228	CDD:275380	9/22 (41%)
		leucine-rich repeat	229..252	CDD:275380	8/23 (35%)
		leucine-rich repeat	253..276	CDD:275380	5/22 (23%)
		leucine-rich repeat	277..300	CDD:275380	5/23 (22%)
		leucine-rich repeat	301..324	CDD:275380	5/22 (23%)
		leucine-rich repeat	325..348	CDD:275380	7/24 (29%)
		leucine-rich repeat	349..370	CDD:275380	7/20 (35%)
		leucine-rich repeat	373..393	CDD:275380	9/19 (47%)
		leucine-rich repeat	397..418	CDD:275380	7/20 (35%)
CG4168	NP_609740.4	PRK15370	<69..>353	CDD:185268
		leucine-rich repeat	99..118	CDD:275380
		leucine-rich repeat	122..146	CDD:275380
		leucine-rich repeat	147..170	CDD:275380
		leucine-rich repeat	171..194	CDD:275380
		leucine-rich repeat	195..214	CDD:275380
		leucine-rich repeat	215..236	CDD:275380
		leucine-rich repeat	266..287	CDD:275380
		leucine-rich repeat	288..311	CDD:275380
		leucine-rich repeat	312..338	CDD:275380
		LRR	<338..651	CDD:443914	94/306 (31%)
		leucine-rich repeat	339..365	CDD:275380
		leucine-rich repeat	366..388	CDD:275380	5/20 (25%)
		leucine-rich repeat	389..412	CDD:275380	8/22 (36%)
		leucine-rich repeat	414..436	CDD:275380	9/22 (41%)
		leucine-rich repeat	437..459	CDD:275380	9/24 (38%)
		leucine-rich repeat	460..483	CDD:275380	7/22 (32%)
		leucine-rich repeat	484..510	CDD:275380	9/25 (36%)
		leucine-rich repeat	511..534	CDD:275380	9/22 (41%)
		leucine-rich repeat	535..589	CDD:275380	19/72 (26%)
		LRR	543..971	CDD:443914	63/215 (29%)
		leucine-rich repeat	590..613	CDD:275380	5/22 (23%)
		leucine-rich repeat	614..639	CDD:275380	7/24 (29%)
		leucine-rich repeat	640..663	CDD:275380	8/22 (36%)
		leucine-rich repeat	664..687	CDD:275380	10/22 (45%)
		leucine-rich repeat	688..711	CDD:275380	8/22 (36%)
		leucine-rich repeat	712..735	CDD:275380	8/27 (30%)
		leucine-rich repeat	740..783	CDD:275380
		leucine-rich repeat	785..808	CDD:275380
		leucine-rich repeat	809..832	CDD:275380
		leucine-rich repeat	833..856	CDD:275380
		leucine-rich repeat	857..879	CDD:275380
		leucine-rich repeat	880..900	CDD:275380
		leucine-rich repeat	905..928	CDD:275380
		LRR	911..>1203	CDD:443914
		leucine-rich repeat	929..952	CDD:275380
		leucine-rich repeat	953..977	CDD:275380
		leucine-rich repeat	978..1020	CDD:275380
		leucine-rich repeat	1045..1068	CDD:275380
		leucine-rich repeat	1069..1090	CDD:275380
		leucine-rich repeat	1091..1114	CDD:275380
		leucine-rich repeat	1115..1161	CDD:275380
		leucine-rich repeat	1162..1190	CDD:275380
		PCC	1230..>1298	CDD:188093