DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4b1 and Cyp4p1

DIOPT Version :9

Sequence 1:	NP_031849.1	Gene:	Cyp4b1 / 13120	MGIID:	103225	Length:	511	Species:	Mus musculus
Sequence 2:	NP_524828.1	Gene:	Cyp4p1 / 45524	FlyBaseID:	FBgn0015037	Length:	513	Species:	Drosophila melanogaster

Alignment Length:	538	Identity:	148/538 - (27%)
Similarity:	248/538 - (46%)	Gaps:	82/538 - (15%)

- Green bases have known domain annotations that are detailed below.

Mouse    15 LWASVVILMVTVLKLLSLLFRRQKLARALDSF-------PGPPKH---------WLFGHALEIQK 63
            ||     |::.:..||..|.|..|....|..|       .|.|..         .:||:.|::.
  Fly     4 LW-----LILALSALLYWLHRANKDYHILSFFTKRIRLKDGTPVEIIAPIAKGKTIFGNTLDLY- 62

Mouse    64 TGGLDKVVTWTEQFPYAHPLWLGQFIVFLNIYEPDYAKAVYSRGDPKAA-------------YVY 115
              |.|....:......|..:.. .:|.::      :.||:|:..|..:|             .||
  Fly    63 --GRDHAGVFNYSRERAKEMGT-SYIEYV------FGKAIYNIIDADSAENVLNHPNLITKGLVY 118

Mouse   116 DFFLQWIGKGLLVLEGPKWFQHRKLLTPGFHYDVLKPYVAIFAESTRVMLDKWEKKASENKSFDI 180
            :|...::..|||...|.||...||:|||.||:::|..:..||...::..|.::|  ..:..:..:
  Fly   119 NFLHPFLRTGLLTSTGKKWHARRKMLTPTFHFNILNQFQEIFKTESQKFLLQFE--GQDEVTITL 181

Mouse   181 FCDVGHMALDTLMKCTFG--------KGD---SGLSHSDNSYYLAVSDLTLLMQQRIDSFQYHND 234
            ...:....|:::.:...|        |||   ...|..:..:...:|:..|...:..:.|.
  Fly   182 HDVIPRFTLNSICETAMGVKLDEMAEKGDRYRENFSQIEECFIRRLSNPLLWGDKLFEMFA---- 242

Mouse   235 FIYWLTPHGRRFLRACQIAHDHTDHVIRQRKAALQDEKEQKK-------LQERRHLDFLDILLGA 292
                    .:.|..|..:.|..:..:|.:|:..|:||.::..       ...::....||.|:.|
  Fly   243 --------AKDFASALDVVHRFSSEIIAKRRDLLKDELDKSSSTADDDGFVSKKRFAMLDTLIYA 299

Mouse   293 RDESGIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPMHQQRCREEVRE-ILGDRDSFQ 356
             ::.|: :....:..||||.||||:|||:.|:.:.|..|:|.|..|:.|.:|::| |..|..:..
  Fly   300 -EKDGL-IDHIGICEEVDTLMFEGYDTTSIGLIFGLMNMSLNPDKQELCYQEIQEHIDDDLSNLD 362

Mouse   357 WDDLAQMTYLTMCMKECFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISLHIYALHRNSAVWPD 421
            ...|.::.||...|||..||:|.||.:.|:..:.....:|..||.|:.|::|::.:|||:..|..
  Fly   363 VGQLNKLKYLEYFMKETTRLFPSVPIMGREAVQETELANGLILPKGAQITIHVFDIHRNAKYWDS 427

Mouse   422 PEVFDPLRFSPENMTGRHPFAFMPFSAGPRNCIGQQFAMNEMKVVTALCLLRFEF--SPDPSKIP 484
            ||.|.|.||.|||:..||.:|::|||||.|||||:::||.|||.:..:.|.:|:.  :.||.||.
  Fly   428 PEEFRPERFLPENVQDRHTYAYVPFSAGQRNCIGKKYAMQEMKTLMVVLLKQFKVLKAIDPQKIV 492

Mouse   485 IKVPQLILRSKNGIHLYL 502
            ... .:.||:::.|.:.|
  Fly   493 FHT-GITLRTQDKIRVKL 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4b1	NP_031849.1	p450	47..500	CDD:278495	137/495 (28%)
Cyp4p1	NP_524828.1	p450	54..509	CDD:278495	135/481 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845352
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.850