DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4b1 and Cyp9c1

DIOPT Version :9

Sequence 1:	NP_031849.1	Gene:	Cyp4b1 / 13120	MGIID:	103225	Length:	511	Species:	Mus musculus
Sequence 2:	NP_523850.1	Gene:	Cyp9c1 / 37941	FlyBaseID:	FBgn0015040	Length:	522	Species:	Drosophila melanogaster

Alignment Length:	414	Identity:	99/414 - (23%)
Similarity:	172/414 - (41%)	Gaps:	51/414 - (12%)

- Green bases have known domain annotations that are detailed below.

Mouse   122 IGKGLLVLEGPKWFQHRKLLTPGFHYDVLKPYVAIF----AESTRVMLDKWEKKASENKSFDIFC 182
            |.|.||.|...:|.|.|..|||.|....::....:.    .|:...:..:.:...||.:..|.|.
  Fly   119 ISKSLLSLRDRRWKQMRSTLTPTFTSLKIRQMFELIHFCNVEAVDFVQRQLDAGTSELELKDFFT 183

Mouse   183 DVGHMALDTLMKCTFGKGDSGLSHSDNSYYLAVSDLTLLMQQRIDSFQYHND---FIYWLTPHGR 244
               ....|.:....||...:.....:|.::        .:.|||..|.:...   .:|.|.|...
  Fly   184 ---RYTNDVIATAAFGIQVNSFKDPNNEFF--------SIGQRISEFTFWGGLKVMLYILMPKLM 237

Mouse   245 RFLRACQIAHDHTDHVIRQRKAALQDEKEQKKLQERRHLDFLDILLGAR-----DESG------- 297
            :.||...:..::.|:..:....|::..|||..::.    |.:.:|:.|:     ::.|
  Fly   238 KALRVPVMDMNNVDYFKKLVFGAMKYRKEQSIVRP----DMIHLLMEAQRQFKAEQEGSAESAAQ 298

Mouse   298 ---IKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPMHQQRCREE---VREILGDRDSFQ 356
               .:.:|.||.|:...|...|.:|..:.:|:..|.:.:.|..|::...|   |:|.||:: ...
  Fly   299 QDKAEFNDDDLLAQCLLFFSAGFETVATCLSFTSYELMMNPEVQEKLLAEILAVKEQLGEK-PLD 362

Mouse   357 WDDLAQMTYLTMCMKECFRLYPPVPQVYRQLSKPVTFVDGR-----SLPAGSLISLHIYALHRNS 416
            :|.|..|.||...:.|..|.:||...|.|.........|..     :|....|:.:::.|||.:.
  Fly   363 YDTLMGMKYLNCVVSESLRKWPPAFIVDRMCGSDFQLKDEEGEVVVNLREDDLVHINVGALHHDP 427

Mouse   417 AVWPDPEVFDPLRFSPENMTGRHPFAFMPFSAGPRNCIGQQFAMNEMKVVTALCLLRFEFSPDPS 481
            ..:|:||.|.|.||..|:......|.::||..|.|:|||.:.|:.|:|.:....:||:...|..
  Fly   428 DNFPEPEQFRPERFDEEHKHEIRQFTYLPFGVGQRSCIGNRLALMEVKSLIFQLVLRYHLKPTD- 491

Mouse   482 KIPIKVPQLILRSKNGIHLYLKPL 505
                :.|..::.|.:|..|..:.|
  Fly   492 ----RTPADMMSSISGFRLLPREL 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4b1	NP_031849.1	p450	47..500	CDD:278495	97/407 (24%)
Cyp9c1	NP_523850.1	p450	37..514	CDD:299894	99/414 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900